Cardiac Lesions of Natural and Experimental Infection by Parrot Bornaviruses

Araújo, Josinaldo Lopes; Hameed, Samer Sadeq; Tizard, Ian R.; Escandon, Paulina; Giaretta, Paula R.; Heatley, J. Jill; Hoppes, Sharman; Rech, Raquel R.

doi:10.1016/j.jcpa.2019.11.008

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…Microscopic lesions in the central nervous system are characterized by non-suppurative encephalitis, including mononuclear perivascular cuffing and focal gliosis. Neuritis and ganglioneuritis with mononuclear infiltrations can be observed in peripheral nerves as well as in neuronal ganglia of a broad range of organs [ 13 , 25 , 118 , 119 , 121 , 122 , 145 , 146 , 148 , 150 , 159 ]. Inflammatory cells in bornavirus-associated lesions were identified as mainly CD3-positive T lymphocytes and Iba1-positive macrophages/microglia in perivascular cuffings in the brains of experimentally PaBV-2-infected cockatiels, whereas infiltrates in ganglia of proventriculus and intestine were composed of T lymphocytes, macrophages as well as PAX5-positive B lymphocytes [ 160 ].…”

Section: Clinical Signs Gross Lesions and Histopathologymentioning

confidence: 99%

“…Impaired gastrointestinal motility is assumed to be responsible for delayed transport of the ingesta, resulting in accumulation of feed in the dilated proventriculus, incomplete digestion and shedding of undigested seeds with the feces [ 158 , 200 ]. Peripheral ganglioneuritis may likewise disturb the function of other organ systems, such as the cardiovascular system, but the associated clinical signs have been characterized less well [ 159 ].…”

Section: Pathogenesis Of Bornavirus-induced Diseasesmentioning

confidence: 99%

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Avian Bornavirus Research—A Comprehensive Review

Rubbenstroth

2022

Viruses

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Avian bornaviruses constitute a genetically diverse group of at least 15 viruses belonging to the genus Orthobornavirus within the family Bornaviridae. After the discovery of the first avian bornaviruses in diseased psittacines in 2008, further viruses have been detected in passerines and aquatic birds. Parrot bornaviruses (PaBVs) possess the highest veterinary relevance amongst the avian bornaviruses as the causative agents of proventricular dilatation disease (PDD). PDD is a chronic and often fatal disease that may engulf a broad range of clinical presentations, typically including neurologic signs as well as impaired gastrointestinal motility, leading to proventricular dilatation. It occurs worldwide in captive psittacine populations and threatens private bird collections, zoological gardens and rehabilitation projects of endangered species. In contrast, only little is known about the pathogenic roles of passerine and waterbird bornaviruses. This comprehensive review summarizes the current knowledge on avian bornavirus infections, including their taxonomy, pathogenesis of associated diseases, epidemiology, diagnostic strategies and recent developments on prophylactic and therapeutic countermeasures.

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Section: Clinical Signs Gross Lesions and Histopathologymentioning

confidence: 99%

Section: Pathogenesis Of Bornavirus-induced Diseasesmentioning

confidence: 99%

Avian Bornavirus Research—A Comprehensive Review

Rubbenstroth

2022

Viruses

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“…Furthermore, it has been recently documented that sudden death due to cardiac ganglioneuritis and myocarditis might be an important clinical manifestation of PDD [ 19 ].…”

Section: Diagnostic Techniquesmentioning

confidence: 99%

“…Due to the possibility of cardiac disease induced by PDD, cardiac imaging techniques such as an echocardiogram might be a useful technique. It has been documented that an echocardiogram of a case of naturally occurring PDD revealed tachycardia, arrythmia, pericardial effusion, ventricular dilatation, decreased ventricular fractional shortening and mitral regurgitation [ 19 ].…”

Section: Diagnostic Techniquesmentioning

confidence: 99%

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Seeing beyond a Dilated Proventriculus: Diagnostic Tools for Proventricular Dilatation Disease in Psittacine Birds

Araújo

Rech

2021

Animals

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Proventricular dilatation disease (PDD) is a life-threatening neurological disease caused by parrot bornaviruses (PaBVs) that affects several species worldwide. PDD can be clinically manifested as either a central nervous system condition or a gastrointestinal condition if the nerves and ganglia of the gastrointestinal tract are compromised. We intend to provide a concise review for veterinary clinicians and diagnosticians with focus on the main tools available for PDD diagnosis, including gross and histopathology, immunohistochemistry, molecular techniques and serology. We suggest that a combination of different strategies can increase the success of diagnostic outcomes, as tools such as reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) can be implemented for identification of bornaviral infections in live patients, and gross pathology, histopathology, immunohistochemistry and RT-PCR can provide reliable results for postmortem diagnosis of PDD.

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Cardiovascular System

Donahoe

2024

Pathology of Pet and Aviary Birds

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Cardiac Lesions of Natural and Experimental Infection by Parrot Bornaviruses

Cited by 9 publications

References 21 publications

Avian Bornavirus Research—A Comprehensive Review

Avian Bornavirus Research—A Comprehensive Review

Seeing beyond a Dilated Proventriculus: Diagnostic Tools for Proventricular Dilatation Disease in Psittacine Birds

Cardiovascular System

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