Cardiac lipids in rats and gerbils fed oils containing C₂₂ fatty acids

Abstract

Docosenoic acid from rapeseed oil or herring oil in the diet of the young rat promoted an accumulation of cardiac lipid. The triglyceride fraction accounted for most of the deposited fat and contained a high concentration of the docosenoic acid. Liquid rapeseed oil, partially hydrogenated rapeseed oil or partially hydrogenated herring oil increased the amount of cardiac fatty acids at 1 week and led to the development of degenerative lesions at 16 weeks. Whale or seal oils low in C22 fatty acids produced little effect on the amount of lipids in the heart of rats or gerbils. The latter species receiving 20% rapeseed oil in the diet showed a peak in cardiac lipid deposition at 4 days with similar levels of total fatty acids to that of rats, but with a lower concentration of erucic acid. Oil fromLimnanthes douglasii and hydrogenated herring oil also increased the amount of cardiac fatty acids in gerbils. A high intake of docosenoic acid was common to the animals displaying the cardiac alterations.

Short-Term and Long-Term Pathological Effects of Glyceryl Trierucate and of Increasing Levels of Dietary Rapeseed Oil in Rats

“…These acids might prove to be the factors responsible for the poor growth performance and patho logical effects observed in animals fed some marine oils [8,[21][22][23],…”

Production of lipase‐catalyzed solid fat from mustard oil and palm stearin with linoleic acid by response surface methodology

“…9 Further, high consumption of erucic acid may increase concentration of adrenal cholesterol, cause fibrotic changes in myocardium, and increase liver weight and cholesterol. 10,11 Palm oil is widely used in food applications, providing various fractions after the winterization process in which palm stearin (PS), one of the fractions, is mainly composed of high-melting triacylglycerides. 12 The purpose of this study was to develop solid fat from MO and PS through a lipase-catalyzed reaction, in which linoleic acid (LA) was intentionally incorporated owing to its beneficial health effects.…”

Erucic acid content in some rapeseed/mustard cultivars developed in Bangladesh

“…8 It has been shown in experimental animals that high intake of this type of oil may increase the content of adrenal cholesterol, may interfere with reproduction, cause fibrotic changes in myocardium and increase liver weight and liver cholesterol. 9,10 Metabolic studies have been conducted on Indian subjects to investigate the effects of using fish oils and linolenic acid (18:3 n-3) rich oils (canola oil and high erucic mustard oil) in comparison with oils those contain negligible amounts of linolenic acid (18:3) (groundnut oil and palmolein), on plasma lipids, essential fatty acid status and platelet aggregation. The results showed that at a level of 6-7 energy % linoleic (18:2 n-6), about 0.20-0.50 energy % fish oils or 1.40 energy % linolenic acid produced antiatherogenic effects.…”