Cardiac Masses: Pathological and Surgical Features — A Multicenter Study

Taşdemi̇r, Arzu; Tunçay, Aydın; Karaman, Hati̇ce; Canöz, Özlem; Aşik, Ramazan; Özmen, Rıfat; Elçik, Deniz

doi:10.21470/1678-9741-2020-0225

Cited by 3 publications

(1 citation statement)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These masses can be divided into non-neoplastic masses (such as thrombi, vegetations, calcifications, or other rare conditions), pseudotumors (lesions not originating from a neoplastic transformation of a specific cell type), benign tumors, or malignant tumors. Non-neoplastic masses account for 75% of all cases [ 1 , 2 ]. Although cardiac tumors are rare, primary cardiac tumors have a prevalence of 0.001–0.03%, while metastatic cardiac tumors occur 10–1,000 times more frequently (2.3–18.3%) [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

The usefulness of contrast echocardiography in the evaluation of cardiac masses: a multicenter study

Wang,

Zhang

et al. 2024

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Cardiac masses can encompass a variety of conditions, such as tumors, thrombi, vegetations, calcific lesions, and other rare diseases. Treatment and management of these types of cardiac masses differ considerably. Thus, accurately distinguishing among thrombi, benign tumors, and malignant tumors in the heart is of great importance. Contrast echocardiography (CE) has emerged as a promising technology. Although published guidelines suggest that CE can enhance image quality and assist in differentiating between benign and malignant lesions, most studies on CE diagnosis of cardiac masses are limited to case reports or retrospective/small-sample-sized prospective cohorts. This study aims to evaluate the diagnostic accuracy of CE in patients with suspected cardiac masses and address the insufficient evidence for differential diagnosis using CE. Methods Between April 2018 and July 2022, a prospective multicenter study was conducted, which included 145 consecutive patients suspected to have cardiac masses based on transthoracic echocardiography. All patients underwent CE examinations. The echocardiographic diagnosis relied on qualitative factors such as echogenicity, boundary, morphology of the base, mass perfusion, pericardial effusion, and motility as well as quantitative factors such as the area of the masses and the peak intensity ratio of the masses to adjacent myocardium (A1/A2). Results The final confirmed diagnoses were as follows: 2 patients had no cardiac mass, 4 patients had pseudomass, 43 patients had thrombus, 66 patients had benign tumors, and 30 patients had malignant tumors. The receiver operating characteristic (ROC) analysis indicated that an optimal A1/A2 cutoff value of 0.499 distinguished a cardiac tumor from a thrombus, with AUC, sensitivity, specificity, PPV, and NPV of 0.977, 97.9%, 90.7%, 95.9%, and 95.1%, respectively. The optimal A1/A2 cutoff value of 1.583 distinguished a cardiac tumor from a thrombus, with AUC, sensitivity, specificity, PPV, and NPV of 0.950, 93.3%, 93.9%, 87.5%, and 96.9%, respectively. Conclusions Combined with qualitative and quantitative analyses, CE has the potential to accurately differentiate among different types of cardiac masses.

show abstract

Section: Introductionmentioning

confidence: 99%

The usefulness of contrast echocardiography in the evaluation of cardiac masses: a multicenter study

Wang,

Zhang

et al. 2024

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

Clinical characteristics and surgical outcomes of cardiac myxoma: A meta-analysis of worldwide experience

Oktaviono,

Saputra,

Arnindita

et al. 2024

European Journal of Surgical Oncology

View full text Add to dashboard Cite

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report and Review of Literature

Kordjazy

Taheri

Parkhideh

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Sarcomas are the most prevalent type of malignant primary cardiac tumor. Clinical presentation differs according to the size and location of the tumor and involvement of other structures. Case presentation: In this article, we present a 38 years old lady as a case of primary cardiac angiosarcoma with a huge challenge in diagnosis and management of the disease. On the 4th of June 2020, she emergently presented to the hospital with the chief complaint of cough and tachypnea, diarrhea, and malaise, and a history of blunt chest trauma three weeks ago. Based on the presentation and transthoracic echocardiography which was compatible with cardiac tamponade, emergent pericardiocentesis was performed. The first imaging showed bilateral pleural effusion, pericardial effusion, and no significant parenchymal lung involvement, which was not compatible with rheumatologic diseases or COVID-19. Based on cardiac CT angiography and evidence of dye entrance to the peri-right atrial area, right atrial free wall rupture was suspected as the cause of the massive pericardial effusion. Following multidisciplinary consensus, she underwent cardiac surgery; in addition to the 3*3 cm right atrium free wall rupture repair, concomitant sampling from the lung nodules, lymph nodes, pericardium, and also the surrounding tissue of the right atrium ruptured defect was performed. Based on immunohistochemistry, the diagnosis was compatible with cardiac angiosarcoma with metastasis to the lung. Due to the advanced stage of the tumor, oncologists advised against chemotherapy or radiotherapy and she went through palliative care. Finally, after a 53-day ICU stay and due to right-sided heart failure, the patient unfortunately died. Conclusion: COVID-19 pandemic has brought diagnostic challenges regarding differentiating SARS-CoV-2 infection from other diagnostic entities. On the other hand, due to the rarity and fatality of primary cardiac angiosarcomas, early diagnosis and possible management seem crucial for prolonged survival. Involving cardiac angiosarcoma in the initial differential diagnosis could warrant timely diagnosis and assessment of various therapies for cure or palliative care.

show abstract

Cardiac Masses: Pathological and Surgical Features — A Multicenter Study

Cited by 3 publications

References 20 publications

The usefulness of contrast echocardiography in the evaluation of cardiac masses: a multicenter study

The usefulness of contrast echocardiography in the evaluation of cardiac masses: a multicenter study

Clinical characteristics and surgical outcomes of cardiac myxoma: A meta-analysis of worldwide experience

Primary Cardiac Angiosarcoma With Pulmonary Metastasis in a Young Female: A Case Report and Review of Literature

Contact Info

Product

Resources

About