Cardiac metastasis from a bronchial carcinoid: report of a case presenting with diffuse thickening of the left ventricular wall

Goddard, Martin; Atkinson, Carl

doi:10.1136/jcp.2004.016055

Cited by 9 publications

(8 citation statements)

References 7 publications

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“…Even if patients do not complain of any symptoms, patients with carcinoid tumors should be followed up carefully using effective inspection methods. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors (3,(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). The characteristics of the reported patients are shown in Table Ⅰ.…”

Section: Discussionmentioning

confidence: 99%

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

et al. 2012

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Abstract. Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the features of skeletal metastasis of carcinoid tumors. The first case involved a 59-year-old man with a history of multiple metastases of a lung carcinoid tumor. The patient complained of back pain and numbness in the lower limbs. Magnetic resonance imaging revealed metastases in the thoracic spine. A spinal decompression was performed and the symptoms were resolved. The second case involved a 74-year-old man had been diagnosed with a lung carcinoid tumor 15 years previously and complained of left thigh pain. A radiograph showed osteolytic lesions in the shaft of the left femur. We repaired the femur using an intramedullary nail following curettage of the tumor. A radiograph of the femur revealed a callus on the pathological fracture. The patient was able to walk using a crutch 3 months after surgery. We reviewed 50 cases that described skeletal metastasis from carcinoid tumors. The average age of the patients was 54.9 years and 33 patients (66%) were male. The most common site of skeletal metastasis was the spine. We also investigated the survival rate of patients who developed skeletal metastasis from carcinoid tumors. The findings showed that survival of patients who developed osteolytic skeletal metastasis was worse than that of patients who developed osteosclerotic skeletal metastasis.

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Section: Discussionmentioning

confidence: 99%

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

et al. 2012

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“…Based on the current experience of 36 published case reports in the literature, it is apparent that the majority of cardiac metastases originate from NET of the gastrointestinal tract [21] . Other sites of the primary tumor include the pancreas [23] and bronchopulmonary system [24,25] , but in individual patients the location of the primary tumor is unknown [26] . The occurrence of myocardial metastases has been described more often in patients with functioning tumors than in those with nonfunctioning tumors, although the significance of this observation is unclear.…”

Section: Cardiac Metastasesmentioning

confidence: 99%

“…Cardiac metastases rarely display clinical symptoms ( ! 30%) but when present include dyspnea, arrhythmias or accentuation of the carcinoid syndrome [22,24,[34][35][36][37][38] .…”

Section: Clinical Presentationmentioning

confidence: 99%

ENETS Consensus Guidelines for the Management of Brain, Cardiac and Ovarian Metastases from Neuroendocrine Tumors

et al. 2010

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“…33 Varied clinical presentations include constrictive pericarditis, 34 complete heart block, 35 ST-segment elevation myocardial infarction due to coronary spasm, 36 and restrictive cardiomyopathy. 37 A clinical presentation with cyanosis and hypoxia secondary to a combination of right-sided heart disease and an interatrial shunt due to the presence of patent foramen ovale (PFO) has also been reported. 38,39 An interesting clinical finding may be dermatitis of sun-exposed areas, due to pellagra resulting from niacin deficiency, as up to 60% of tryptophan is used in serotonin synthesis by the tumor.…”

Section: Clinical Featuresmentioning

confidence: 96%

Carcinoid Heart Disease

Palaniswamy

Frishman

Aronow

2012

Cardiology in Review

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Carcinoid tumors are rare, indolent neuroendocrine tumors that are often associated with a syndrome characterized by episodic flushing, secretory diarrhea, bronchospasm, and hypotension-the carcinoid syndrome. Cardiac involvement occurs in one-half to two-thirds of patients with carcinoid syndrome and is associated with a worse clinical outcome. Carcinoid heart disease is characterized by endocardial plaque-like deposits found predominantly on right-sided heart valves, leading to the combination of valvular stenosis and regurgitation. Left-sided cardiac involvement can also occur in <10% of patients. Somatostatin analogs form the therapeutic cornerstone in the medical management of these patients. Cytotoxic chemotherapy has had only limited success in the treatment of metastatic carcinoid tumors. Hepatic resection or palliative cytoreduction may be of benefit in patients with limited hepatic disease. Hepatic artery embolization is usually applied if a patient is not eligible for surgical debulking. The development and progression of carcinoid heart disease are associated with an unfavorable outcome. In those patients having severe cardiac involvement and well-controlled systemic disease, valve replacement surgery has been found to be an effective treatment that can both relieve intractable symptoms and contribute to improved clinical outcomes.

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Cardiac metastasis from a bronchial carcinoid: report of a case presenting with diffuse thickening of the left ventricular wall

Cited by 9 publications

References 7 publications

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature

ENETS Consensus Guidelines for the Management of Brain, Cardiac and Ovarian Metastases from Neuroendocrine Tumors

Carcinoid Heart Disease

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