Cardiac metastatic melanoma: Imaging diagnostic clues

Pedrotti, Patrizia; Musca, Francesco; Torre, Massimo; Pirola, Roberto; Biase, Anna Maria De; Fieschi, Stefano; Quattrocchi, G; Roghi, Alberto; Giannattasio, Cristina

doi:10.1016/j.jccase.2015.03.001

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Our systematic literature review identified 1012 articles with 36 studies meeting inclusion criteria (Figure S1 ). 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 All studies received an evidence level of 4 based on the OCEBM Levels of Evidence categorization with a total of 40 individual cases of cardiac metastasis of melanoma identified from these studies.…”

Section: Resultsmentioning

confidence: 99%

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Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes

et al. 2022

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Background Cardiac metastasis of melanoma is rare and typically diagnosed post‐mortem. Here we perform a retrospective cohort study and systematic review of patients with metastatic melanoma to characterize prevalence, clinical characteristics, and outcomes of cardiac metastasis. Methods We reviewed the electronic medical records of all outpatients with metastatic melanoma who underwent evaluation at the University of Michigan in Ann Arbor from January 2009 to January 2022, identifying patients with a clinical or histopathologic diagnosis of cardiac metastasis. We performed a systematic review of the literature to summarize the clinical characteristics and outcomes of patients with melanoma and cardiac metastasis. Results Overall, 23 of 1254 (1.8%) patients with metastatic melanoma were diagnosed with cardiac metastasis. Cardiac metastasis was reported in the right ventricle (65%), left ventricle (35%), and right atrium (35%). A total of 11 (48%) patients experienced at least one cardiovascular complication after the diagnosis of cardiac metastasis, the most common being arrhythmia (30%), heart failure (22%), and pericardial effusion (17%). Immunotherapy was more commonly used in patients with cardiac metastasis (80% vs 65%; p = 0.005). Mortality at 2‐years post‐diagnosis was higher for patients with cardiac metastasis compared to those without (59% vs 37%; p = 0.034). Progression of malignancy was the underlying cause of death of all patients. Conclusions Cardiac metastasis occurs in <2% of patients with metastatic melanoma, can affect all cardiac structures, and is associated with various cardiovascular complications and high mortality.

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Section: Resultsmentioning

confidence: 99%

“…Our systematic literature review identified 1012 articles with 36 studies meeting inclusion criteria (Figure S1). 19‐50 All studies received an evidence level of 4 based on the OCEBM Levels of Evidence categorization with a total of 40 individual cases of cardiac metastasis of melanoma identified from these studies.…”

Section: Resultsmentioning

confidence: 99%

Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes

et al. 2022

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“…In a case report by Pedrotti et al [23] , they present a rare and unique case indicating metastatic melanoma, with a large amount of effusion, in both the pericardium and myocardium. The tumor origin was confirmed as metastasis of melanoma by echocardiography, cardiac CT, and CMR imaging, but the pathological malignancy by pericardiocentesis was not evident.…”

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confidence: 99%

Editorial: Cardiac tumors: Histopathological aspects and assessments with cardiac noninvasive imaging

Isobe¹,

Murohara

2015

Journal of Cardiology Cases

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“…In fact, in a few cases of metastasizing cardiac melanoma, the paramagnetic nature of melanin has led to the type of tumor being identified by MRI. 4 In some other series, the histopathological diagnosis had already been made by endomyocardial biopsy at the time of intervention. Given the short survival time associated with PMCTs, especially sarcoma, imaging studies are particularly valuable in order to select candidates for surgery, which can be extensive.…”

mentioning

confidence: 99%

Primary malignant cardiac tumors: Surgical results

Fragata

2016

Revista Portuguesa de Cardiologia (English Edition)

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Cardiac metastatic melanoma: Imaging diagnostic clues

Cited by 5 publications

References 6 publications

Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes

Metastatic melanoma of the heart: Retrospective cohort study and systematic review of prevalence, clinical characteristics, and outcomes

Editorial: Cardiac tumors: Histopathological aspects and assessments with cardiac noninvasive imaging

Primary malignant cardiac tumors: Surgical results

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