Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region

Wu, Yingchun; Yue, Yan; Xiong, Sidong

doi:10.1016/j.antiviral.2023.105702

Antiviral Research

2023

DOI: 10.1016/j.antiviral.2023.105702

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Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region

Yingchun Wu,

Yan Yue,

Sidong Xiong

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Cited by 2 publications

References 45 publications

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The miR‐184‐3p promotes rice black‐streaked dwarf virus infection by suppressing Ken in Laodelphax striatellus (Fallén)

Wu,

Wang,

Deng

et al. 2023

Pest Management Science

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BACKGROUNDMicroRNAs (miRNAs) play a key role in various biological processes by influencing the translation of target messenger RNAs (mRNAs) through post‐transcriptional regulation. The miR‐184‐3p has been identified as an abundant conserved miRNA in insects. However, less is known about its functions in insect–plant virus interactions.RESULTSThe function of miR‐184‐3p in regulation of plant viral infection in insects was investigated using a rice black‐streaked dwarf virus (RBSDV) and Laodelphax striatellus (Fallén) interaction system. We found that the expression of miR‐184‐3p increased in L. striatellus after RBSDV infection. Injection of miR‐184‐3p mimics increased RBSDV accumulation, while treatment with miR‐184‐3p antagomirs inhibits the viral accumulation in L. striatellus. Ken, a zinc finger protein, was identified as a target of miR‐184‐3p. Knockdown of Ken increased the virus accumulation and promoted RBSDV transmission by L. striatellus.CONCLUSIONThis study demonstrates that RBSDV infection induces the expression of miR‐184‐3p in its insect vector L. striatellus. The miR‐184‐3p targets Ken to promote RBSDV accumulation and transmission. These findings provide a new insight into the function of the miRNAs in regulating plant viral infection in its insect vector. © 2023 Society of Chemical Industry.

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The miR‐184‐3p promotes rice black‐streaked dwarf virus infection by suppressing Ken in Laodelphax striatellus (Fallén)

Wu,

Wang,

Deng

et al. 2023

Pest Management Science

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The Role of MicroRNA in the Pathophysiology and Diagnosis of Viral Myocarditis

Młynarska,

Badura,

Kurciński

et al. 2024

IJMS

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Myocarditis is a non-ischemic condition with a heterogeneous etiology, clinical course and prognosis. The most common etiology of myocarditis are viral infections, whereas the most severe complications are acute and chronic heart failure and sudden cardiac death. The heterogeneous clinical course of the disease, as well as the availability and costs of diagnostic tools such as cardiac magnetic resonance and endomyocardial biopsy, hinder the diagnosis of myocarditis and its underlying cause. Non-coding RNAs such as micro-RNAs (miRNAs; miR) have been shown to be involved in the disease’s pathophysiology; however, their potential in disease diagnosis and treatment should also be considered. Non-coding RNAs are RNAs that are not translated into proteins, and they have the ability to regulate several intracellular pathways. MiRNAs regulate gene expression by binding with their targets and inhibiting protein synthesis by interfering with the translation of coding genes or causing the degradation of messenger RNA. Several miRNAs, such as miR-1, -133, -21, -15, -98, -126, -155, -148, -203, -208, -221, -222, -203 and -590, have been shown to be involved in the pathophysiology of viral myocarditis (VMC), and some of them have been shown to have diagnostic abilities. This article summarizes the available data on miRNAs and their associations with VMC.

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Cardiac miR-19a/19b was induced and hijacked by CVB3 to facilitate virus replication via targeting viral genomic RdRp-encoding region

Cited by 2 publications

References 45 publications

The miR‐184‐3p promotes rice black‐streaked dwarf virus infection by suppressing Ken in Laodelphax striatellus (Fallén)

The miR‐184‐3p promotes rice black‐streaked dwarf virus infection by suppressing Ken in Laodelphax striatellus (Fallén)

The Role of MicroRNA in the Pathophysiology and Diagnosis of Viral Myocarditis

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