Cardiac Myxoma After Treatment for Childhood Neuroblastoma

Hill, G L; Castellino, Sharon M.; Williams, Derek A.

doi:10.1007/s00246-008-9304-2

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Myxomas have been reported in a few patients after immunosuppression for solid organ transplant [9]. Inflammation also appears to be a trigger for CLL development [10].…”

Section: Discussionmentioning

confidence: 99%

A Case of Comorbid Myxoma and Chronic Lymphocytic Leukemia: Not Just a Coincidence?

Laird-Fick

Tiwari

Narayanan

et al. 2014

Case Reports in Oncological Medicine

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Background. It is unclear why cardiac myxomas develop. We describe a case of comorbid myxoma and chronic lymphocytic leukemia (CLL) to offer insights into the tumor's pathophysiology. Case. A 56-year-old female with recurrent venous thromboembolism developed embolic stroke. Transesophageal echocardiogram showed a 1.7 × 1 cm sessile left atrial mass at the interatrial septum. Histopathology revealed myxoma with a B cell lymphocytic infiltrate suggestive of a low grade lymphoproliferative disorder. Bone marrow biopsy and flow cytometry of blood and the cardiac infiltrate supported the diagnosis of atypical CLL. She was followed clinically in the absence of symptoms, organ infiltration, or cytopenia. After eighteen months, she developed cervical and axillary lymphadenopathy. Biopsy confirmed B cell CLL/small lymphocytic lymphoma. She elected to undergo chemotherapy with fludarabine, cyclophosphamide, and rituximab, with clinical remission. Conclusions. The coexistence of two neoplastic processes may be coincidental, but the cumulative likelihood is estimated at 0.002 per billion people per year. A shared pathogenic mechanism is more likely. Possibilities include chronic inflammation, vascular endothelial growth factor A, shared genetic mutations, changes in posttranslational regulation, or alterations in other cellular signaling pathways. Additional studies could expand our current understanding of the molecular biology of both myxomas and CLL.

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“…Myxomas have been reported in a few patients after immunosuppression for solid organ transplant [9]. Inflammation also appears to be a trigger for CLL development [10].…”

Section: Discussionmentioning

confidence: 99%

A Case of Comorbid Myxoma and Chronic Lymphocytic Leukemia: Not Just a Coincidence?

Laird-Fick

Tiwari

Narayanan

et al. 2014

Case Reports in Oncological Medicine

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“…Hill et al reported an incidental case of cardiac myxoma in a child with neuroblastoma as well but after 5.5 years of being off therapy who also survived after complete resection of the tumour. 6 Due to the possibility of cardiac myxoma embolism and the risk of sudden death, surgery should be performed as soon as possible once cardiac myxoma is diagnosed to remove as much of the tissue surrounding the tumour as possible and reduce the recurrence rate. 7 In conclusion, our case describes incidental finding of cardiac lesion in a child with neuroblastoma that mimicked a cardiac thrombus at initial finding.…”

Section: Discussionmentioning

confidence: 99%

Incidental finding of atrial myxoma following curative treatment for paediatric neuroblastoma

Legro,

Mehta,

Patel

2023

Cardiol Young

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“…As a result of diagnosis suspicion bias, the knowledge that the patient has been diagnosed with one disease (neoplasm) influences the intensity of their search for another condition. 10 Some case reports, however, describe cardiac myxomas as a late complication in cancer survivors, hypothesizing that chemotherapy, radiotherapy, or immunosuppression [11][12][13] may have contributed to the tumor's growth. 14,15 Cardiac tumors are rare, and any spaceoccupying mass noted on cardiovascular imaging modalities should be considered as part of the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Mixoma auricular izquierdo: importancia de la imagen cardiovascular en el seguimiento a largo plazo de las sobrevivientes de cáncer de mama

Alanís-Naranjo,

Galeana-Abarca,

Rentería-Galicia

et al. 2023

Cardiovasc Metab Sci

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La incidencia de pacientes con cáncer y enfermedades cardiacas que requieren cirugía aumenta a medida que la población envejece. La detección temprana del cáncer y el uso de nuevas terapias aumentan las tasas de supervivencia. Los tumores cardiacos, a pesar de su rareza, son una parte integral de la cardio-oncología, requiriendo diagnóstico y tratamiento. En los últimos años, la incidencia de tumores cardiacos ha aumentado debido a los avances en los estudios de imagen, que se han vuelto más accesibles. La asociación entre el cáncer de mama y el mixoma podría considerarse una mera coincidencia, pero hay pocos casos documentados. Presentamos el caso de una paciente con antecedente de cáncer de mama que, durante el seguimiento, presentó

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Cardiac Myxoma After Treatment for Childhood Neuroblastoma

Cited by 4 publications

References 10 publications

A Case of Comorbid Myxoma and Chronic Lymphocytic Leukemia: Not Just a Coincidence?

A Case of Comorbid Myxoma and Chronic Lymphocytic Leukemia: Not Just a Coincidence?

Incidental finding of atrial myxoma following curative treatment for paediatric neuroblastoma

Mixoma auricular izquierdo: importancia de la imagen cardiovascular en el seguimiento a largo plazo de las sobrevivientes de cáncer de mama

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