Methods This review is based on research of the current literature regarding the epidemiology of CM, its clinical presentation, diagnosis, and treatment. The PubMed database was searched for eligible studies and the search was restricted to the years 2000 to 2019. The search term was "cardiac myxoma" and we included observational or retrospective studies with large samples of patients who were treated for CM only. In addition, the data of interest to the present review were long-term follow-up, the recurrence rate during follow-up, and the survival rate after CM resection. Additionally, we looked for studies on novel surgical techniques for CM resection and those describing unusual CM location or clinical presentation. The primary source for data extraction were 24 articles from 15 countries, which reported on a total of 2205 patients with CM (TABLE 1). 1-24 We included studies from Europe, North and South America,