Cardiac myxoma in a dog

Darke, P. G. G.; Gordon, Lee

doi:10.1136/vr.95.25-26.565

Cited by 29 publications

(34 citation statements)

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“…Early slaughtering is probably the cause of rare incidence of neoplasm. The neoplasm was reported in heart (Darke and Gordon, 1974;Campbell and Gelberg, 2000), lungs (Paliwal and Baxi, 1979), spleen (West, 1974), spinal canal (Teague and Berg, 1978), skin (Muller et al, 1983;Yeruham et al, 1999), skeletal muscle (Crankson et al, 2002;Okamoto et al, 2002), subcutaneous and aponeurotic tissue, genitourinary tract, liver and bones (Pulley and Stannard, 1990;Allen, 2000). The neoplasm was detected on the right side of the crop (related with subcutaneous connective tissue) in this case.…”

Section: Discussionmentioning

confidence: 99%

“…Although its incidence is rare (Muller et al, 1983;Pulley and Stannard, 1990;Okamoto et al, 2002), myxoma usually occurs in man and in all domestic animals with no breed or sex predilections (Muller et al, 1983;Pulley and Stannard, 1990;Crankson et al, 2002). Myxoma is extremely rare in cats, dogs (Darke and Gordon, 1974;Muller et al, 1983;Campbell and Gelberg, 2000) and birds (Erturk and Pamukcu, 1974;Yang and Lee, 1987). In a study (Erturk and Pamukcu, 1974) of 612 birds during the period of 1933-1974, only a single myxoma was detected among 81 neoplasms.…”

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Case report of a myxoma in a gamecock

Yaman¹,

Durgun²,

Karabulut³

2004

Vet. Med. - Czech

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ABSTRACT:A mass was detected on the right side of the crop of a 17-month-old gamecock. Macroscopically, the excised mass, 10 × 7.0 × 4.0 cm in size, was ovoid-shaped with a smooth surface and a few lobules. Microscopically, the individual neoplasm cell was stellate or fusiform in shape and the cell nucleus was round, ovoid or elongated, with multiple nucleoli. No hypercellular or pleomorphic areas were identified and no mitoses were observed. The mass was myxoma according to the macroscopic and microscopic results of this study.

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Section: Discussionmentioning

confidence: 99%

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Case report of a myxoma in a gamecock

Yaman¹,

Durgun²,

Karabulut³

2004

Vet. Med. - Czech

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“…2,21,27 Primary intrapericardial sarcomas, excluding hemangiosarcoma, were not observed in this study. Only individual cases of such tumors have been previously reported, 1,7,8,15,17,23,[25][26][27] reflecting their rare occurrence.…”

Section: Discussionmentioning

confidence: 99%

“…Other mesenchymal and epithelial tumors have been sporadically reported. 1,4,7,8,11,12,14,15,17,18,20,23,[25][26][27] Ratios of primary intrapericardial versus metastatic neoplasms and of metastatic mesenchymatous versus epithelial neoplasms are unknown.A 6-year retrospective study was done to determine the incidence of primary or metastatic intrapericardial neoplasia in the dog. The relative frequency of primary versus metastatic and metastatic mesenchymatous versus epithelial neoplasms affecting the pericardium, the heart base, and the pericardium were also investigated.…”

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Intrapericardial Neoplasia in Dogs

Girard

Hélie

Odin³

1999

J VET Diagn Invest

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Abstract.A retrospective study was conducted from 1,919 necropsies of dogs, and 52 cases were selected on the basis of primary or metastatic neoplasia in the pericardium, the heart base, or the myocardium. Primary intrapericardial neoplasms were more frequent than intrapericardial metastases. Hemangiosarcomas were the most frequent primary neoplasms, followed by chemodectomas. Lymphomas were the most frequent metastatic neoplasms, followed by fibrosarcomas and rhabdomyosarcomas. Other neoplasms, either primary or metastatic, occurred rarely.Neoplasms affecting the pericardium, the heart base or the myocardium are infrequent in the dog, representing only a small proportion of necropsy cases. 6,27 Hemangiosarcomas 4,13,27 and chemodectomas 2,4,27,28 are the most frequently observed. Other mesenchymal and epithelial tumors have been sporadically reported. 1,4,7,8,11,12,14,15,17,18,20,23,[25][26][27] Ratios of primary intrapericardial versus metastatic neoplasms and of metastatic mesenchymatous versus epithelial neoplasms are unknown.A 6-year retrospective study was done to determine the incidence of primary or metastatic intrapericardial neoplasia in the dog. The relative frequency of primary versus metastatic and metastatic mesenchymatous versus epithelial neoplasms affecting the pericardium, the heart base, and the pericardium were also investigated. Materials and methodsSelection of cases. Necropsies were performed on 1,919 dogs over a 6-yr period (January 1990 to December 1995 at the Faculty of Veterinary Medicine, University of Montreal. Neoplasms were diagnosed in 184 cases, and 52 of these were selected for study based on their intrapericardial localization.Light microscopy. Tissues were fixed in buffered 10% formalin, embedded in paraffin, sectioned at 5 m, and stained with hematoxylin, phloxin, and saffron (HPS). Giemsa, periodic acid-Schiff, phosphotungstic acid-hematoxylin, Gridley's reticulin and/or Grimelius stains were used on selected sections.Immunoperoxidase. Monoclonal antibodies a were used to detect the presence of desmin, vimentin, alpha-smooth muscle actin (SMA), myoglobin, and cytokeratin and polyclonal antibodies were used for calcitonin, thyroglobulin, muramidase, alpha-1 antitrypsin, kappa-lambda light chains, a and factor VIII-related antigen b on selected neoplasms to confirm the diagnosis. Sections were cut at 5 m and mounted on Received for publication May 14, 1997.slides precoated with poly-D-lysine. Sections were stained by the avidin-biotin complex method using standard reagents. c Sections were deparaffinized in successive xylene immersions, dehydrated through graded ethanols, and rehydrated in distilled water. Endogenous peroxidase activity was blocked with 3% hydrogen peroxide diluted in methanol. Sections were incubated overnight at 4 C with appropriate primary antibody in a humidified chamber, followed by incubation at room temperature in a humidified chamber with appropriate biotinylated antibodies. Sections were then covered with freshly prepared avidin-biotin-peroxidase solu...

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“…9 Cardiac myxomas are rare primary heart tumors in dogs. 2,3,8,10,13,14 In humans, myxomas compose 50% of primary cardiac neoplasms and present as a single lesion or with other proliferative lesions as Carney complex (CNC). 7 CNC is a genetically heterogeneous, autosomal dominant syndrome resulting in multiple cardiac, endocrine, cutaneous, and neural tumors, as well as a variety of pigmented lesions of the skin and mucosae.…”

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Cardiac Myxosarcoma With Adrenal Adenoma and Pituitary Hyperplasia Resembling Carney Complex in a Dog

et al. 2010

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A 9-year-old female Golden Retriever was presented with an acute onset of progressive respiratory distress. Echocardiography revealed a left atrial mass that limited blood flow from the pulmonary veins. The pathological evaluation revealed a left atrial ossifying myxosarcoma, bilateral adrenocortical adenomas, multifocal pituitary hyperplasia with expression of adrenocorticotrophic hormone, and multiple pituitary Rathke's cleft cysts. These pathologic findings are similar to those described in Carney complex, a familial human syndrome characterized by cardiac myxoma and extracardiac tumors associated with mutations in the protein kinase A regulator gene PRKAR1A. Mutations were not detected in PRKAR1A exons in the present case.

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Cardiac myxoma in a dog

Cited by 29 publications

References 0 publications

Case report of a myxoma in a gamecock

Case report of a myxoma in a gamecock

Intrapericardial Neoplasia in Dogs

Cardiac Myxosarcoma With Adrenal Adenoma and Pituitary Hyperplasia Resembling Carney Complex in a Dog

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