Cardiac neural crest

Stoller, Jason Z.; Epstein, Jonathan A.

doi:10.1016/j.semcdb.2005.06.004

Cited by 179 publications

(183 citation statements)

References 133 publications

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“…Heart septation defects (ventricular and atrial septal defects, and persistent truncus arteriosus, abbreviated as VSD, ASD, and PTA, respectively), associated with defects of migration of the cardiac neural crest cells (Table 1), are among the most highly occurring human congenital heart defects. DiGeorge syndrome, characterized by heart defects, craniofacial abnormalities and severe retardation, has been linked to chromosome deletions that result in migratory defects of the neural crest cells (Epstein, 2001;Epstein and Parmacek, 2005;Gitler et al, 2002;Hutson and Kirby, 2007;Stoller and Epstein, 2005). Hirschsprung's disease, characterized by impaired bowel movement, is related to defects in migration of the vagal and sacral neural crest lineages that populate the gastrointestinal system and subsequently differentiate into the neurons responsible for gut innervation (Amiel et al, 2008;Heanue and Pachnis, 2007;Tucker, 2004).…”

Section: Cell Migration and Human Diseasementioning

confidence: 99%

Cell biology of embryonic migration

Kurosaka¹,

Kashina²

2008

Birth Defects Research Pt C

117

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Cell migration is an evolutionarily conserved mechanism that underlies the development and functioning of uni-and multicellular organisms and takes place in normal and pathogenic processes, including various events of embryogenesis, wound healing, immune response, cancer metastases, and angiogenesis. Despite the differences in the cell types that take part in different migratory events, it is believed that all of these migrations occur by similar molecular mechanisms, whose major components have been functionally conserved in evolution and whose perturbation leads to severe developmental defects. These mechanisms involve intricate cytoskeleton-based molecular machines that can sense the environment, respond to signals, and modulate the entire cell behavior. A big question that has concerned the researchers for decades relates to the coordination of cell migration in situ and its relation to the intracellular aspects of the cell migratory mechanisms. Traditionally, this question has been addressed by researchers that considered the intra-and extracellular mechanisms driving migration in separate sets of studies. As more data accumulate researchers are now able to integrate all of the available information and consider the intracellular mechanisms of cell migration in the context of the developing organisms that contain additional levels of complexity provided by extracellular regulation. This review provides a broad summary of the existing and emerging data in the cell and developmental biology fields regarding cell migration during development.

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Section: Cell Migration and Human Diseasementioning

confidence: 99%

Cell biology of embryonic migration

Kurosaka¹,

Kashina²

2008

Birth Defects Research Pt C

117

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“…5), like the vertebrate cardiac neural crest cells, undergo migration, associate with cardiac primordia, and contribute to the final heart morphogenesis. A conserved family of Lbx/Lb homeodomain transcription factors is required for specification of both the Drosophila HANC and the vertebrate cardiac neural crest cells (20,23). As demonstrated here, the rate of HANC migration and the precise HANC-heart tip cell-cell recognition are regulated by the Slit/Robo/Shg pathway, which emerges as an effective system for controlling multicomponent organ assembly.…”

Section: Resultsmentioning

confidence: 65%

“…Interestingly, it has been shown that the vertebrate heart develops from two distinct myocardial precursor cells derived from (i) trunk mesoderm and (ii) pharyngeal mesoderm (secondary heart field). The formation of the cardiac OFT depends on cells derived from the pharyngeal mesoderm (21) and also involves a subpopulation of migrating nonmesodermal neural crest cells expressing Lb/ Lbx1 (22)(23). Thus, the identification of COM muscles originating from the pharyngeal mesoderm and the epidermally derived Lb-expressing HANC cells as components of the Drosophila cardiac OFT suggests an additional similarity between the Drosophila heart and the vertebrate heart.…”

mentioning

confidence: 99%

Cellular components and signals required for the cardiac outflow tract assembly in Drosophila

Zmojdzian

Ponte²,

Jagla³

2008

Proc. Natl. Acad. Sci. U.S.A.

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Specification of cardiac primordia and formation of the Drosophila heart tube is highly reminiscent of the early steps of vertebrate heart development. We previously reported that the final morphogenesis of the Drosophila heart involves a group of nonmesodermal cells called heart-anchoring cells and a pair of derived from the pharyngeal mesoderm cardiac outflow muscles. Like the vertebrate cardiac neural crest cells, heart-anchoring cells migrate, interact with the tip of the heart, and participate in shaping the cardiac outflow tract. To better understand this process, we performed an in-depth analysis of how the Drosophila outflow tract is formed. We found that the most anterior cardioblasts that form a central outflow tract component, the funnel-shaped heart tip, do not originate from the cardiac primordium. They are initially associated with the pharyngeal cardiac outflow muscles and join the anterior aorta during outflow tract assembly. The particular morphology of the heart tip is disrupted in embryos in which heart-anchoring cells were ablated, revealing their critical role in outflow tract morphogenesis. We also demonstrate that Slit and Robo are required for directed movements of heart-anchoring cells toward the heart tip and that the cell-cell contact between the heart-anchoring cells and the ladybird-expressing cardioblasts is critically dependent on DE-cadherin Shotgun. Our observations suggest that the similarities between Drosophila and vertebrate cardiogenesis extend beyond the early developmental events.heart ͉ shotgun ͉ slit

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“…18 This may in part reflect a special tropism of the neural crest cells to the heart; cardiac formation involves a critical neural crest invasion, certainly contributing to the endocardial cushion structures and possibly to other components of the myocardium and epicardium. 19,20 The invasion of the myocardium by the tumor may result in supraventricular and ventricular arrhythmias, primarily monomorphic ventricular tachycardia. Our illustrative case represents an unusual manifestation of cardiac metastasis presenting as PMVT.…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Presentation for Cardiac Melanoma

Baykalır¹,

Young²,

Slosky³

et al. 2014

Journal of Patient-Centered Research and Reviews

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Journal of Patient-Centered Research and Reviews ( JPCRR) is a peerreviewed scientific journal whose mission is to communicate clinical and bench research findings, with the goal of improving the quality of human health, the care of the individual patient, and the care of populations. Recommended Citation An Uncommon Presentation for Cardiac Melanoma AbstractA 66-year-old man with locally advanced malignant melanoma, which was surgically resected, presented with a 3-week history of dizziness, recurrent near-syncopal episodes and generalized weakness. He was found to have sustained polymorphic ventricular tachycardia in the setting of cardiac melanoma. We draw attention to an unusual presentation of malignant melanoma with cardiac metastasis and discuss both its etiology and treatment options. (J Patient-Centered Res Rev. 2014;1:128-132.)

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Cardiac neural crest

Cited by 179 publications

References 133 publications

Cell biology of embryonic migration

Cell biology of embryonic migration

Cellular components and signals required for the cardiac outflow tract assembly in Drosophila

An Uncommon Presentation for Cardiac Melanoma

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