Cardiac programming in rats submitted to leptin treatment during lactation

Spontaneous and Isoprenaline-evoked response of isolated heart preparations from rats submitted to leptin treatment during lactation

“…1). These data also corroborate the findings of Marques et al whose echocardiographic studies have inferred a systolic dysfunction in these older animals [5].…”

“…Analyzing the left ventricle relaxation rate it is possible to observe that the hearts of rats at 30 days of age submitted to neonatal leptin treatment presented a lower spontaneous lusitropic activity when compared to control, without changes of spontaneous inotropic activity. These data corroborates the diastolic dysfunction suggested by Marques et al in this experimental model [5]. Heart preparations from rats at 150 days of age of Leptin group presented a lower spontaneous inotropic activity when compared to control, considering both LV developed pressure as the systolic contractility rate (Fig.…”

“…Trevenzoli et al had previously described that leptin treatment during the first 10 days of lactation increased catecholamine synthesis and secretion [4]. Echocardiographic studies have shown cardiac dysfunction compatible with diastolic heart failure in this experimental model in early age that evolved to systolic dysfunction in adulthood [5]. The aim of the present work was to study the spontaneous cardiac activity of isolated heart preparations from rats at 30 and 150 days of age treated with leptin during the first 10 days of lactation, also investigating their response to β-adrenergic stimulation.…”

“…This study was performed at the Laboratory of Experimental Pharmacology of Fluminense Federal University and approved by local Ethics Committee (CEPA/UFF00123-09). Wistar rats were treated with leptin (PeproTech Inc., London, UK) at a dose of 8 mg/100 g body weight daily for the first 10 days of lactation or saline (Control-Leptin naïve) as previously described [2,4,5].…”

Developmental programming by maternal obesity in 2015: Outcomes, mechanisms, and potential interventions

“…In addition, the programming of obesity and psychiatric disorders by maternal obesity has been attributed to increased maternal-foetal inflammatory signalling (Bolton and Bilbo, 2014;Marques et al, 2014a). It has recently been shown that the impairment in Arc-PVH neuropeptide Y (NPY) projections seen in mice exposed to maternal DIO may be due to increased foetal exposure to the inflammatory cytokine interleukin-6 (IL-6) .…”