Cardiac Protective Effects of<i>Moringa oleifera</i>Seeds in Spontaneous Hypertensive Rats

Randriamboavonjy, Joseph Iharinjaka; Loirand, Gervaise; Vaillant, Nathalie; Lauzier, Benjamin; Derbré, Séverine; Michalet, Serge; Pacaud, Pierre; Tesse, Angela

doi:10.1093/ajh/hpw001

Cited by 69 publications

(61 citation statements)

References 37 publications

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“…The beneficial vascular effects observed in the present work are probably due to the presence in the seeds of tocopherols, phenolic acids (gallic and ferulic acids), and flavonoids (such as quercetin, catechin, and epicathechin) known for their potential antioxidant activity [34]. Moreover, we previously identified glucosinolates, in particular glucomoringin, in MOI seeds extract that can also contribute to its cardiovascular protective role [11]. Glucomoringin hydrolysis by myrosinase activity during food processing or digestion leads to the formation of isothiocianates (ITCs) [35].…”

Section: Discussionmentioning

confidence: 85%

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Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats

Randriamboavonjy

Rio

Pacaud

et al. 2017

Oxidative Medicine and Cellular Longevity

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Moringa oleifera (MOI) is a tree currently used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including arterial hypertension. We previously described a cardiac protective role of a treatment with MOI seeds in spontaneously hypertensive rats (SHR). Here, we investigated the effects of this treatment on oxidative and nitrosative vascular stresses in SHR, with normotensive Wistar Kyoto rats used as controls. Oxidative and nitrosative stresses detected in SHR aortas using the fluorescent dye dihydroethidine and protein nitrotyrosine staining were reduced in MOI-treated SHR aortas. This was associated with a decrease of free 8-isoprostane circulating level, vascular p22phox and p47phox expressions, and SOD2 upregulation. Moreover, circulating nitrites and C-reactive protein, increased in SHR, were both reduced in SHR receiving MOI. This was associated to decrease iNOS and NF-κB protein expressions after MOI treatment. In functional studies, the endothelium-dependent carbachol-induced relaxation was improved in MOI-treated SHR resistance arteries. Oral administration of MOI seeds demonstrates vascular antioxidant, anti-inflammatory, and endothelial protective effects in SHR. Our data support the use of MOI seeds in diet against cardiovascular disorders associated with oxidative stress and inflammation such as hypertension, scientifically validating the use of these seeds in Malagasy traditional medicine.

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Section: Discussionmentioning

confidence: 85%

“…Malagasy population employs MOI seeds against hypertension empirically, and in our previous study, we provided evidence of the cardiac protective role of a treatment with MOI seeds in spontaneously hypertensive rats (SHR) [11]. A physicochemical study suggested antioxidant properties of MOI seed oil [12].…”

Section: Introductionmentioning

confidence: 99%

Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats

Randriamboavonjy

Rio

Pacaud

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Furthermore, a significant reduction in fibrosis in the left ventricle was also observed. However, treatment with M. oleifera seed powder did not modify blood pressure [68]. …”

Section: Phytochemistry and Medicinal Usesmentioning

confidence: 99%

Moringa oleifera Seeds and Oil: Characteristics and Uses for Human Health

Leone

Spada

Battezzati

et al. 2016

IJMS

285

166

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Moringa oleifera seeds are a promising resource for food and non-food applications, due to their content of monounsaturated fatty acids with a high monounsaturated/saturated fatty acids (MUFA/SFA) ratio, sterols and tocopherols, as well as proteins rich in sulfated amino acids. The rapid growth of Moringa trees in subtropical and tropical areas, even under conditions of prolonged drought, makes this plant a reliable resource to enhance the nutritional status of local populations and, if rationalized cultivation practices are exploited, their economy, given that a biodiesel fuel could be produced from a source not in competition with human food crops. Despite the relatively diffuse use of Moringa seeds and their oil in traditional medicine, no pharmacological activity study has been conducted on humans. Some encouraging evidence, however, justifies new efforts to obtain clear and definitive information on the benefits to human health arising from seed consumption. A critical review of literature data concerning the composition of Moringa oil has set in motion a plan for future investigations. Such investigations, using the seeds and oil, will focus on cultivation conditions to improve plant production, and will study the health effects on human consumers of Moringa seeds and their oil.

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“…An aqueous leaf extract from MO was reported to have lipid-lowering properties through reduction in the formation of cholesterol micelles and inhibition of pancreatic lipase, pancreatic cholesterol esterase, and bile acid binding [34]. In addition, upregulation of the expression of peroxisome proliferator-activated receptors (PPAR) α1 (PPARα1) and γ (PPARγ) has been observed in rats which received MO seed powder [55]. PPAR are crucial for lipid metabolism, ketogenesis, and cellular energetic homeostasis, and are expressed in several organs including liver, brain, muscle, and heart, among others.…”

Section: Mechanisms Of Action Of Momentioning

confidence: 99%

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

2019

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Diabetes and related neurological complications are serious worldwide public health problems. The increasing number of affected individuals make it necessary to implement novel nutritional and therapeutic interventions. The tree Moringa oleifera (MO) has been used as a food source and for traditional medicine purposes due to possible antihyperglycemic, antioxidant, anti-inflammatory, and lipid regulating properties. These properties may be explained by the presence of numerous phytochemicals in the leaves, fruits, roots and, oil of the tree. The evidence for acute antihyperglycemic effects of MO extract on diabetic animal models seems to be robust, but more chronic and long-term studies are needed. In contrast, the hypoglycemic effects of MO on humans are not as clear. The scarce number of human studies, together with a diverse range of methodologies and MO doses, may explain this. In addition, evidence regarding changes in insulin levels due to MO intervention is ambiguous, both in animal and human studies. Therefore, more structured studies are needed to clarify if MO has an effect on insulin levels or activity.

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Cardiac Protective Effects ofMoringa oleiferaSeeds in Spontaneous Hypertensive Rats

Cited by 69 publications

References 37 publications

Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats

Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats

Moringa oleifera Seeds and Oil: Characteristics and Uses for Human Health

Effects of Moringa oleifera on Glycaemia and Insulin Levels: A Review of Animal and Human Studies

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