Cardiac Rhythm Disturbances in the Obstructive Sleep Apnea Syndrome

Harbison, J.; O’Reilly, Philip; McNicholas, Walter T.

doi:10.1378/chest.118.3.591

Cited by 216 publications

(35 citation statements)

References 27 publications

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“…More recently, recordings obtained for several consecutive weeks have documented bradyarrhythmia in 47% of patients with untreated OSAS with a large intra-individual variability accounting for the higher prevalence compared with previous studies [185] and possibly for some negative results by previous investigations based on single-night Holter recordings [186]. Furthermore, CPAP therapy abolished pathological dysrhythmias in OSAS patients within a period of 24-48 h [187]; long-term recordings also documented disappearance of arrhythmias after a few weeks of CPAP treatment [184]. A high prevalence of OSAS was found in patients in whom Holter recordings showed isolated bradyarrhythmias during sleep [188].…”

Section: Arrhythmiasmentioning

confidence: 88%

Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities: Fig. 1—

Mr²

2006

Eur Respir J

790

479

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Considerable evidence is available in support of an independent association between obstructive sleep apnoea syndrome (OSAS) and cardiovascular disease, which is particularly strong for systemic arterial hypertension and growing for ischaemic heart disease, stroke, heart failure, atrial fibrillation and cardiac sudden death.The pathogenesis of cardiovascular disease in OSAS is not completely understood but likely to be multifactorial, involving a diverse range of mechanisms including sympathetic nervous system overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormal coagulation and metabolic dysregulation, the latter particularly involving insulin resistance and disordered lipid metabolism.The present report, which arose out of a European Union Cooperation in the field of Scientific and Technical Research (COST) action on OSAS (COST B26), reviews the current evidence for an independent association and proposes research priorities to identify the underlying mechanisms involved, with a view to identifying novel therapeutic strategies.Large-scale collaborative studies of carefully defined patient populations with obstructive sleep apnoea syndrome, adequately controlled for potential confounders, are needed. Such studies carry the prospect of evaluating potential interactions between different basic mechanisms operating in obstructive sleep apnoea syndrome and cardiovascular disease, and interactions with other related disorders, such as obesity, diabetes and dyslipidaemia. Furthermore, translational studies involving cell culture and animal models linked to studies of obstructive sleep apnoea syndrome patients are necessary to integrate basic mechanisms with the clinical disorder.

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Section: Arrhythmiasmentioning

confidence: 88%

Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities: Fig. 1—

Mr²

2006

Eur Respir J

790

479

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“…Arrhythmias in 4 patients with premature ventricular contractions decreased during sleep, and remained frequent during wakefulness. Several other case series have shown that nocturnal cardiac rhythm disturbances were reduced following OSA treatment 1995;Grimm et al, 2000;Harbison et al, 2000;Koehler et al, 1998;Tilkian et al, 1977). It was surprising, therefore, in a recent retrospective cohort study of 2626 patients with OSA, that CPAP use did not affect the incidence of atrial fibrillation (Gami et al, 2007).…”

Section: Treating Osamentioning

confidence: 94%

Sleep-Related Breathing Disorders and Cardiac Arrhythmia

Hersi¹

2012

Cardiac Arrhythmias - New Considerations

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“…Abnormal cardiac pattern of sudden deaths amongst OSA could possibly be explained due to higher incidences of life threatening ventricular arrhythmias amongst patients with sleep disorders 18 . OSA not only increases the prevalence of atrial fibrillation (AF) but also predicts predischarge AF after surgery and recurrent post ablation 16,[19][20][21] .…”

Section: Cardiac Arrhythmiasmentioning

confidence: 99%

Diagnosis and Management of Obstructive Sleep Apnea

Mehta¹,

Ariga²

2014

J Biol Sci Opin

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Sleep is defined as a naturally recurring state characterized by altered consciousness, relatively inhibited sensory activity and inhibition of nearly all voluntary muscles. Poor sleep quality results in excessive daytime sleepiness, impaired health status, depressive symptoms and poor quality of life. Upper airway sleep disorders (UASD) are becoming commonly recognized by medical and dental communities. Snoring is a mild form of these disorders. Obstructive Sleep Apnea (OSA) is a severe yet under-diagnosed sleep related breathing disorder. It is characterized by repetitive complete or partial occlusion of the upper airway, resulting in apnea, hypopnea, oxygen desaturation and sleep fragmentation. OSA can lead to a series of systemic, dental and psychological problems if left untreated. Efforts have been made to pin-point the symptoms to effectively evaluate this disorder and to efficiently treat it. This review gives a brief description on the evaluation criteria, associated systemic complications and series of invasive and non invasive treatment options for management and improvement of individuals affected with OSA.

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Cardiac Rhythm Disturbances in the Obstructive Sleep Apnea Syndrome

Cited by 216 publications

References 27 publications

Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities: Fig. 1—

Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities: Fig. 1—

Sleep-Related Breathing Disorders and Cardiac Arrhythmia

Diagnosis and Management of Obstructive Sleep Apnea

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