Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome – a pilot study

Petrides, George; Zalewski, Paweł; McCulloch, David K.; Maclachlan, Laura; Finkelmeyer, Andreas; Hodgson, Tim; Blamire, Andrew M.; Newton, Julia L.

doi:10.1080/21641846.2017.1322235

Cited by 2 publications

(3 citation statements)

References 8 publications

(7 reference statements)

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“…The pathogenesis of CFS is still unclear. Immune system dysfunction plays a crucial role in the progression of CFS (12,13), including abnormal levels of immunoglobulins, unbalanced levels of antiviral antibodies. Chronic immune activation leads to increased or decreased cytokine release and thus disrupts the neuro-endocrine-immune system, leading to CFS symptoms.…”

Section: Discussionmentioning

confidence: 99%

Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome

He¹,

Yu²,

Wu³

et al. 2020

Ann Palliat Med

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Background: There are close relationships between the spleen and limb muscles and thoughts. The study aims to test the effects of ginsenoside Rg1 in combination with acupuncture of the Beishu acupoint on T cell subsets of rats with chronic fatigue syndrome (CFS). Methods:The model was set up by combining forced cold-water swimming with chronic restraint. The rats were randomly divided into blank control, model, ginsenoside, acupuncture, and ginsenoside plus acupuncture groups (n=10). For the acupuncture group, the Beishu acupoint was acupunctured on the 2nd day after modeling. For the ginsenoside group, the ginsenoside Rg1 solution was injected into the tail vein on the 2nd day after modeling. For the combination group, both processes were conducted. These groups were compared regarding exhausted swimming time, number of struggles, resting time, serum levels of IgA, IgG, IgM, IFN-α, IFN-β, and IFN-γ, lymphocyte transformation rate, T cell subsets, and skeletal muscle activities of malondialdehyde (MDA), total antioxidative capacity (T-AOC) and acetylcholinesterase (Ache). Results:The exhausted swimming time, number of struggles, and resting time of combination group surpassed those in the ginsenoside and acupuncture groups significantly (P<0.05). The serum levels of IgA, IgG, IgM, IFN-β, IFN-γ, T-AOC, and Ache, together with CD3 + and CD8 + T cell percentages of combination groups, were significantly higher than those of ginsenoside and acupuncture groups. However, the IFN-α level, MDA activity, and CD4 + T cell percentage were significantly lower (P<0.05). Compared with the model group, the CD4 + /CD8 + T cell ratios of acupuncture, ginsenoside, and combination groups decreased significantly (P<0.05). Compared with the combination group, the ratio of the ginsenoside group increased significantly (P<0.05).Conclusions: Both acupuncture of the Beishu acupoint and intravenous injection of ginsenoside Rg1 have anti-fatigue effects, and their combination works synergistically. This study supplies an experimental basis for joint therapy using acupuncture and drugs to combat fatigue synergistically.

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Section: Discussionmentioning

confidence: 99%

Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome

He¹,

Yu²,

Wu³

et al. 2020

Ann Palliat Med

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“…[64][65][66][67] Cardiac sympathetic innervation is associated with autonomic dysfunction in ME/CFS. 68 The coronavirus disease 2019 (COVID-19) pandemic, which began in 2020, is causing unprecedented morbidity, mortality, and disruption around the world. It has been noted that ME/CFS also has been occurring in patients with COVID-19.…”

Section: Other Smentioning

confidence: 99%

“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a multisystem illness characterized by various symptoms including autonomic and cognitive dysfunction 64–67 . Cardiac sympathetic innervation is associated with autonomic dysfunction in ME/CFS 68 . The coronavirus disease 2019 (COVID‐19) pandemic, which began in 2020, is causing unprecedented morbidity, mortality, and disruption around the world.…”

Section: Othersmentioning

confidence: 99%

Recent advances in autonomic neurology: An overview

Nakane

2021

Neurology & Clinical Neurosc

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The autonomic nervous system (ANS) is a component of the nervous system that regulates involuntary functions, including heart rate, blood pressure, respiration, digestion, and bladder function.It comprises three anatomically distinct divisions: sympathetic, parasympathetic, and enteric. 1 The sympathetic and parasympathetic nervous systems contain afferent and efferent fibers that respectively provide sensory input and motor output to the central nervous system (CNS). 1 Autonomic neurology, the science exploring the key findings of the development, function, and dysfunction of the ANS, both in health and disease, is a branch of neurology that has grown exponentially with the advance in neuroscience, genetics, and immunology. This special issue titled "Recent Advances in Autonomic Neurology" aimed to document and increase the visibility of the current discoveries in this vast field, and four review covers pertinent topics (Figure 1).

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Cardiac sympathetic innervation associates with autonomic dysfunction in chronic fatigue syndrome – a pilot study

Cited by 2 publications

References 8 publications

Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome

Acupuncture of the Beishu acupoint participates in regulatory effects of ginsenoside Rg1 on T cell subsets of rats with chronic fatigue syndrome

Recent advances in autonomic neurology: An overview

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