Cardiac troponin‐I and its prognostic significance in a dialysis population

Hussein, Magdi; Mooij, J. M. V.; Roujouleh, Haysam; Shenawi, Omer Al

doi:10.1111/j.1492-7535.2004.80406.x

Cited by 8 publications

(9 citation statements)

References 35 publications

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“…The results of a study carried out by Hussein et al on 93 asymptomatic HD patients showed that cTnI significantly correlated with the outcome of all-cause mortality after one year (17).…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the Correlation Between Cardiac Troponin I Versus Causes of Admission and In-Hospital Mortality in End-Stage Renal Disease Patients

2021

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Objectives: There are arguments regarding the relationship between the level of cardiac troponin I (cTnI) and presence of cardiac diseases in end-stage renal disease (ESRD) patients. This study aimed to determine the relationship between positivity of cTnI and cause of admission and patients’ outcome in ESRD patients. Methods: In this cross-sectional study, all ESRD patients who had checked cTnI and admitted to two university hospitals in Isfahan, Iran were enrolled. The patients’ demographic characteristics, cause of admission, and outcome were correlated with cTnI positivity. Results: Out of a total of 348 ESRD patients, 100 subjects had positive cTnI. There was a positive correlation between age and admission in Al-Zahra hospital with positive cTnI. In contrast, vascular access complication and hypertension had a negative correlation with positivity of cTnI. The results of multiple logistic regression analysis showed that factors including age (OR: 1.04; 95% CI: 1.01 - 1.07; P: 0.004) and infections (OR: 3.1; 95% CI: 1.3 - 7.3; P: 0.009) were associated with increased risk of in-hospital mortality. In contrary, exit site infection (OR: 0.11; 95% CI: 0.01 - 0.8; P: 0.03) and hypertension (OR = 0.32; 95% CI: 0.14 - 0.77; P = 0.01) were associated with decreased risk of mortality. Although cTnI positivity correlated with patients’ in-hospital mortality (OR = 2.038). Conclusions: Although positive cTnI had a borderline association with in-hospital mortality in ESRD patients, further multicenter studies with larger sample size are required to confirm the results.

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“…The results of a study carried out by Hussein et al on 93 asymptomatic HD patients showed that cTnI significantly correlated with the outcome of all-cause mortality after one year (17).…”

Section: Discussionmentioning

confidence: 96%

Evaluation of the Correlation Between Cardiac Troponin I Versus Causes of Admission and In-Hospital Mortality in End-Stage Renal Disease Patients

2021

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“…in their study on 93 asymptomatic HD patients showed that cTnI has a high specificity for the diagnosis of myocardial infarction in dialysis patients and it was found to be significantly correlated with the outcome of all-cause mortality at 1 year. [ 20 ] Resic et al . reported that periodical hemodynamics or underlying cardiac disease with speciﬁc alterations of cardiac musculature in uremia would be some possible reasons for cTnI elevation.…”

Section: Discussionmentioning

confidence: 99%

Association between troponin I level and cardiovascular risk factors in asymptomatic hemodialysis patients

Taheri¹,

Pilehvarian²,

Akbari³

et al. 2016

J Res Pharm Pract

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Objective:Patients on hemodialysis (HD) have a high risk for cardiovascular morbidity and mortality. Cardiac troponins are biomarkers for diagnosing acute myocardial injury or infarction. There is considerable controversy that exists in the frequency and significance of cardiac troponins in predicting cardiac injury and ischemia in HD patients.Methods:In this cross-sectional study, all HD patients more than 18-year-old, who were at least 3 months under HD, and had no sign and symptom of active cardiovascular disease (CVD), in two HD centers were enrolled. One hundred and one patients fulfilled the inclusion criteria. Blood sample for cardiac troponin I (cTnI) was drown before the initiation of HD session during their routine monthly blood testing from patients’ vascular access arterial line. cTnI levels were measured by a high-sensitivity assay, VIDAS troponin I Ultra kit, and correlated with patients’ demographic, clinical, and laboratory results.Findings:The patients’ different demographic and clinical characteristics had no statistically significant correlation with troponin levels except for marginal trend for past medical history of diabetes and hyperlipidemia with corresponding P values of 0.072 and 0.055. Twenty-six patients had cTnI level more than 0.01 ΅g/L and only two patients had cTnI level more than 0.11 ΅g/L. For laboratory results, only fasting blood sugar had statistically significant correlation with patients’ cTnI level (r = 0.357, P = 0.0001).Conclusion:Frequency of significant elevation of cTnI level in our asymptomatic HD patients was very low and if such elevation is found in this population, it may be considered as a sign of active CVD.

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“…Furthermore, elevated serum cTnT levels are frequently observed in asymptomatic chronic dialysis patients [12] and have been shown to be associated with increased morbidity and mortality [13,14,15,16,17], although other reports [18, 19] found cTnT to be of no predictive value. cTnI, which is less frequently elevated, has also been associated with increased morbidity and mortality [20, 21]. However, cTnT has been found to be less specific than cTnI for the diagnosis of acute cardiac event in ESRD patients [22,23,24,25,26].…”

Section: Discussionmentioning

confidence: 99%

Prediction of Hemodynamically Significant Coronary Artery Disease Using Troponin I in Hemodialysis Patients Presenting with Chest Pain: A Case-Control Study

Badero¹,

Salifu

2009

Cardiology

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Objectives: Controversy exists regarding utility of cardiac troponin I (cTnI) in predicting significant coronary artery disease (CAD) in hemodialysis (HD) patients with chest pain and no acute ischemia on electrocardiogram (non-ST segment elevation myocardial infarction, non-STEMI). We sought to determine if cTnI elevation predicts significant CAD (>70% stenosis) in these patients. Methods: Ninety patients with non-STEMI referred for cardiac catheterization were included, divided equally into HD and non-HD groups. Results: Mean age and baseline characteristics were not significantly different between groups, except for left ventricular hypertrophy which was higher in HD patients (56 vs. 27%, p = 0.012). Initial cTnI correlated with obstructive CAD and was stratified into <0.3 and >0.3 ng/ml. By logistic regression, cTnI >0.3 ng/ml was not predictive of CAD in HD patients [odds ratio = 0.87 (95% CI 0.19–4.0), p = 0.8], while non-HD patients had an increased risk of CAD if first cTnI was >0.3 ng/ml [odds ratio = 1.461 (95% CI 1.01–2.11), p = 0.04] as expected. Sensitivity, specificity, negative and positive predictive values of cTnI in predicting obstructive CAD were better in non-HD patients. Conclusion: cTnI in these patients had no predictive value for obstructive CAD. This contrasts with the general population, suggesting a higher index of suspicion for high-grade CAD irrespective of cTnI levels in HD patients.

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Cardiac troponin‐I and its prognostic significance in a dialysis population

Abstract: cT-I has a high specificity for the diagnosis of myocardial infarction in dialysis patients. Despite the relatively low number of positive test results, cT-I was found to be significantly correlated with the outcome all-cause mortality at 1 year.

Cited by 8 publications

References 35 publications

Evaluation of the Correlation Between Cardiac Troponin I Versus Causes of Admission and In-Hospital Mortality in End-Stage Renal Disease Patients

Evaluation of the Correlation Between Cardiac Troponin I Versus Causes of Admission and In-Hospital Mortality in End-Stage Renal Disease Patients

Association between troponin I level and cardiovascular risk factors in asymptomatic hemodialysis patients

Prediction of Hemodynamically Significant Coronary Artery Disease Using Troponin I in Hemodialysis Patients Presenting with Chest Pain: A Case-Control Study

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