Cardiac Troponin I Associated with the Development of Unrecognized Myocardial Infarctions Detected with MRI

Barbier, Charlotte Ebeling; Themudo, Raquel; Bjerner, Tomas; Johansson, Lars; Lindahl, Bertil; Lind, Lars; Åhlström, Håkan

doi:10.1373/clinchem.2014.222430

Cited by 12 publications

(10 citation statements)

References 43 publications

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“…The acquired slice thickness was 10 mm with a resolution of 1.56 x 2.81 mm and the inversion time was individually adjusted. Cine images were acquired during breath holding using asteady state free precession sequence as previously described [ 2 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Long-term prognosis of unrecognized myocardial infarction detected with cardiovascular magnetic resonance in an elderly population

Barbier

Themudo

Bjerner

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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BackgroundIndividuals with unrecognized myocardial infarctions (UMIs) detected with cardiovascular magnetic resonance (CMR) constitute a recently defined group whose prognosis has not been fully evaluated. However, increasing evidence indicate that these individuals may be at considerable cardiovascular risk. The aim of the present study was to investigate the prognostic impact of CMR detected UMIs for major adverse cardiac events (MACE) in community living elderly individuals.MethodsLate gadolinium enhancement CMR was performed in 248 randomly chosen 70-year-olds. Individuals with myocardial infarction (MI) scars, with or without a hospital diagnosis of MI were classified as recognized MI (RMI) or UMI, respectively. Medical records and death certificates were scrutinized. MACE was defined as cardiac death, non-fatal MI, a new diagnosis of angina pectoris, or symptom-driven coronary artery revascularization.ResultsDuring follow-up (mean 11 years) MACE occurred in 10 % (n = 18/182) of the individuals without MI scars, in 20 % (n = 11/55) of the individuals with UMI, and in 45 % (n = 5/11) of the individuals with RMI, with a significant difference between the UMI group and the group without MI scars (p = 0.045), and between the RMI group and the group without MI scars (p = 0.0004). Cardiac death and/or non-fatal MI occurred in 15, 5, and 3 of the individuals in the NoMI, UMI, and RMI group respectively. Hazards ratios for MACE adjusted for risk factors and sex were 2.55 (95 % CI 1.20-5.42; p = 0.015) for UMI and 3.28 (95 % CI1.16-9.22; p = 0.025) for RMI.ConclusionsThe presence of a CMR detected UMI entailed a more than double risk for MACE in community living 70-year-old individuals.

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Section: Methodsmentioning

confidence: 99%

Long-term prognosis of unrecognized myocardial infarction detected with cardiovascular magnetic resonance in an elderly population

Barbier

Themudo

Bjerner

et al. 2016

Journal of Cardiovascular Magnetic Resonance

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“…The level of serum cTn-I was increased in three to five hours, followed by continuous disruption and destruction of myofibril, and cTn-I was constantly released, therefore, cTn-I is a serum marker of high sensitivity and specificity for reflection of myocardial cell damage. 7 A previous study showed both serum cTn-I and CK-MB were significantly increased on the first day of neonatal asphyxia, showing a positive correlation. 8 Therefore, the indicators are of great significance to the diagnosis of myocardial damage and judgment of efficacy and prognosis.…”

Section: Discussionmentioning

confidence: 90%

Clinical effects of Ganglioside and fructose-1, 6-diphosphate on neonatal heart and brain injuries after Asphyxia

2017

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Objective:To study the clinical effect of ganglioside (GM) and fructose-1, 6-diphosphate (FDP) on neonatal heart and brain injuries after asphyxia.Methods:Ninety-one neonates with asphyxia neonatal heart and brain injuries were randomly divided into an observation group and a control group. Both groups were given symptomatic treatment as soon as possible. On this basis, the observation group was given 200 mL of 5% glucose injection and 20 mg of GM and 250 mg/kg·d FDP by intravenous infusion. The above two drugs were given once a day for 14 days. The control group was given 20 mL of 5% glucose injection, 2 mL of cerebrolysin and 250 mg/kg·d FDP by intravenous infusion, once a day for 14 days. Both groups were administered on the first day after admission, and the course of treatment was 14 days. The treatment outcomes of the two groups were compared by detecting the levels of glycogen phosphorylase isoenzyme BB (GPBB), cTn-I and CK-MB, MRI results and Neonatal Behavioral Neurological Assessment (NBNA) scores before and after treatment.Results:The levels of GPBB, cTn-I and CK-MB in the observation group were significantly higher than those of normal neonates. After treatment, the levels of cTn-I and CK-MB in the observation group were closer to those of normal neonates compared with the control group, with significant differences (P<0.05). There was a significant difference in the brain MRI examination between the two groups (P<0.05). The NBNA scores of the two groups were significantly different before and after treatment (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group (P<0.05).Conclusion:Neonatal heart and brain injuries after asphyxia can be well treated by combining GM with FDP.

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“…19 In addition, post-PCI cardiac troponin is of little value as a prognostic factor compared to pre-PCI level. 12,20 On the other hand, chronic elevation of high-sensitivity cardiac troponin level was associated with chronic myocardial injury in the asymptomatic population 21 and was an independent predictor of composite major cardiac adverse events in diabetic patients with SCAD. 9 Furthermore, although a strong association between hs-cTnT and coronary artery plaque burden, or inducible cardiac ischemia, in patients with SCAD has been identified, 3-5 prompt revascularization did not affect the concentration of hs-cTnT at follow-up or clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Cardiac Troponin T and Sex in Patients Undergoing Elective Percutaneous Coronary Intervention

Harada

Michel

Köenig

et al. 2016

JAHA

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BackgroundIn patients with stable coronary artery disease undergoing elective percutaneous coronary intervention, the prognostic value of high‐sensitivity cardiac troponin T (hs‐cTnT) and the influence of sex remain poorly defined.Methods and ResultsConsecutive patients with stable coronary artery disease who underwent elective percutaneous coronary intervention were included. Primary endpoint was all‐cause mortality. Unadjusted hazard ratio (HR) in overall and sex‐specific population and multivariable adjusted HR were calculated by using Cox proportional hazard models. In a total of 5626 patients, elevated hs‐cTnT levels, more than the sex‐specific 99th percentile upper reference limit of normal (URL), were observed in 2221 patients (39%) at baseline. During follow‐up (median, 14.5 months; 25th–75th percentiles, 6.4–27.2 months), 265 patients died. Mortality was higher in patients with the sex‐specific 99th percentile URL compared to those with normal hs‐cTnT (17.3% vs 3.4%; HR=6.10; 95% CI, 4.58–8.14; P<0.001). hs‐cTnT was an independent predictor of mortality in multivariable adjusted models. The C‐statistic was significantly increased by adding hs‐cTnT to the basic prediction model for mortality (0.793–0.815; P<0.001). There was a significant interaction between hs‐cTnT and sex on mortality. Differences in all‐cause mortality between patients with more than the sex‐specific 99th percentile URL and those with normal hs‐cTnT were numerically larger in male than female patients (male, HR=6.45; 95% CI, 4.68–8.87, P<0.001; female, HR=4.29, 95% CI, 2.36–9.03; P<0.001).ConclusionsIn patients with stable coronary artery disease undergoing elective percutaneous coronary intervention, preprocedural hs‐cTnT was a strong predictor of mortality in both men and women.

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Cardiac Troponin I Associated with the Development of Unrecognized Myocardial Infarctions Detected with MRI

Cited by 12 publications

References 43 publications

Long-term prognosis of unrecognized myocardial infarction detected with cardiovascular magnetic resonance in an elderly population

Long-term prognosis of unrecognized myocardial infarction detected with cardiovascular magnetic resonance in an elderly population

Clinical effects of Ganglioside and fructose-1, 6-diphosphate on neonatal heart and brain injuries after Asphyxia

Prognostic Value of Cardiac Troponin T and Sex in Patients Undergoing Elective Percutaneous Coronary Intervention

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