Clinical effects of Ganglioside and fructose-1, 6-diphosphate on neonatal heart and brain injuries after Asphyxia

Zhu, Xiaojing; Hong-ya, LI; Zhang, Congmin

doi:10.12669/pjms.335.12830

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Zhu et al (11) stated that levels of CK-MB began to rise within the first few hours of life and were significantly higher in moderate and severe grades of neonatal hypoxia ischemia compared with mild grades and normal controls within the first 2-4 h. Levels of CKMB in asphyxiated infants rose to a significant peak at 12 h of life before returning to a low level at 48 h of life. There was no significant difference in the serial serum CKMB levels during the first 48 h of life between asphyxiated infants with and without hypotension, between infants who had normal or abnormal ECGs, between infants with and without heart failure, between infants with low and normal EF or between infants who survived or died.…”

Section: Discussionmentioning

confidence: 99%

Role of Creatine Kinase MB in Diagnosis of Myocardial Injury after Neonatal Hypoxia-Ischemia

AbouZied¹,

Khalifa²,

Loudeeni³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Creatine kinase MB (CK-MB), which exists mainly in the cytoplasm of myocardial cells, is currently accepted as an indicator and has high sensitivity and specificity for the diagnosis of myocardial injury. Objective: This study was aimed to estimate serum creatine kinase MB (CK-MB) levels after asphyxia-induced myocardial injury in neonates. Patients and methods: 40 neonates were included in this study and divided into 20 cases with the diagnosis of perinatal hypoxia ischemia and 20 controls admitted to Neonatology Unit of Pediatric Department at Zagazig University. Serum CK-MB levels were estimated in all studied neonates. Results: In the present study serum CK-MB levels in cases were significantly higher than controls. A significant area under curve with cutoff >14.5 (units /L) with sensitivity 99%and specificity 97.5% for CK-MB. Encephalopathy cases were significantly associated with higher HR and CKMB. Cases with organ failure were significantly associated with higher HR and CKMB. Cases with metabolic acidosis were significantly associated with higher HR and CKMB. Conclusion: It could be concluded that cases with hypoxic ischemic encephalopathy (HIE) and those with multiple organ failure had a more pronounced elevation of serum CK-MB compared with cases of hypoxia-ischemia with no organ failure. Similarly, patients with HIE had significant elevation of cardiac enzymes. Collectively, these findings indicate more myocardial systolic dysfunction and damage in neonates with HIE and organ failure.

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Section: Discussionmentioning

confidence: 99%

Role of Creatine Kinase MB in Diagnosis of Myocardial Injury after Neonatal Hypoxia-Ischemia

AbouZied¹,

Khalifa²,

Loudeeni³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Prediction of adverse motor outcome for neonates with punctate white matter lesions by MRI images using radiomics strategy: protocol for a prospective cohort multicentre study

Wang

Liu²,

Liu

et al. 2019

BMJ Open

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IntroductionPunctate white matter lesions (PWML) are prevalent white matter disease in preterm neonates, and may cause motor disorders and even cerebral palsy. However, precise individual-based diagnosis of lesions that result in an adverse motor outcome remains unclear, and an effective method is urgently needed to guide clinical diagnosis and treatment. Advanced radiomics for multiple modalities data can provide a possible look for biomarkers and determine prognosis quantitatively. The study aims to develop and validate a model for prediction of adverse motor outcomes at a corrected age (CA) of 24 months in neonates with PWML.Methods and analysisA prospective cohort multicentre study will be conducted in 11 Chinese hospitals. A total of 394 neonates with PWML confirmed by MRI will undergo a clinical assessment (modified Neonatal Behavioural Assessment Scale). At a CA of 18 months, the motor function will be assessed by Bayley Scales of Infant and Toddler Development-III (Bayley-III). Mild-to-severe motor impairments will be confirmed using the Bayley-III and Gross Motor Function Classification System at a CA of 24 months. During the data collection, the perinatal and clinical information will also be recorded. According to the radiomics strategy, the extracted imaging features and clinical information will be combined for exploratory analysis. After using multiple-modelling methodology, the accuracy, sensitivity and specificity will be computed. Internal and external validations will be used to evaluate the performance of the radiomics model.Ethics and disseminationThis study has been approved by the institutional review board of The First Affiliated Hospital of Xi’an Jiaotong University (XJTU1AF2015LSK-172). All parents of eligible participants will be provided with a detailed explanation of the study and written consent will be obtained. The results of this study will be published in peer-reviewed journals and presented at local, national and international conferences.Trial registration numberNCT02637817; Pre-results.

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Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability

Liu

Shao

et al. 2020

Can. J. Physiol. Pharmacol.

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This study aims to investigate the mechanisms through which Fructose Diphosphate (FDP) causes the anti-hypoxia and anti-fatigue effects, and improves learning and memory. Mice were divided into three groups: FDP-L，FDP-H and a control group. Acute toxic hypoxia induced by carbon monoxide, sodium nitrite and potassium cyanide, and acute cerebral ischemic hypoxia, were used to investigate the anti-hypoxia ability of FDP. The tests of rod-rotating, mouse-tail suspension and swimming endurance were used to explore the anti-fatigue effects of FDP. The Morris water maze experiment was used to determine the impact of FDP on learning and memory ability. Poisoning-induced hypoxic tests showed that mouse survival time was significantly prolonged in the FDP-L and FDP-H groups compared with the control group (p < 0.05). In the exhaustive swimming test, FDP significantly shortened struggling time and prolonged the time of weight-loaded swimming; the rod-rotating test showed that endurance time was significantly prolonged by using FDP (p < 0.05). FDP significantly decreased lactate and urea nitrogen levels, increased hepatic and muscle glycogen, and glucose transporter-4 and Na+-K+-ATPase (p < 0.05). To conclude, FDP enhances hypoxia tolerance and fatigue resistance and improves learning and memory ability through regulating glucose and energy metabolism.

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Clinical effects of Ganglioside and fructose-1, 6-diphosphate on neonatal heart and brain injuries after Asphyxia

Cited by 3 publications

References 7 publications

Role of Creatine Kinase MB in Diagnosis of Myocardial Injury after Neonatal Hypoxia-Ischemia

Role of Creatine Kinase MB in Diagnosis of Myocardial Injury after Neonatal Hypoxia-Ischemia

Prediction of adverse motor outcome for neonates with punctate white matter lesions by MRI images using radiomics strategy: protocol for a prospective cohort multicentre study

Mechanism and effects of fructose diphosphate on anti-hypoxia fatigue and learning memory ability

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