Cardiac troponin I photoelectrochemical sensor: {Mo368} as electrode donor for Bi2S3 and Au co-sensitized FeOOH composite

Bao, Chunzhu; Liu, Xin; Shao, Xinrong; Ren, Xiang; Zhang, Yihe; Sun, Xu; Fan, Dawei; Wei, Qin; Ju, Huangxian

doi:10.1016/j.bios.2020.112157

Cited by 28 publications

(10 citation statements)

References 49 publications

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“…Various molecular biomarkers for AMI have been established, including creatine kinase-MB, myoglobin, cardiac troponin T (cTnT), and cardiac troponin I (cTnI) . Clinical medical assay demonstrated that once a cardiac injury occurs, the level of cTnI in the human blood rises rapidly within 3–4 h. , Thus, cTnI has been accepted as a “golden-standard” biomarker for the diagnosis of AMI by the European Society of Cardiology, the American College of Cardiology, and the Chinese Society of Laboratory Medicine . Therefore, the development of rapid, accurate, and sensitive POCT for cTnI is of considerable importance in the diagnosis in the early development, prognosis, and monitoring of AMI. , Compared to traditional analytical methods such as liquid chromatography/mass spectrometry, chemiluminescent enzyme immunoassay, and radioimmunoassay applications, label-free electrochemical immunosensors are regarded as a promising analytical method owing to the advantages of rapidness, high sensitivity, and low cost.…”

Section: Introductionmentioning

confidence: 99%

“…Various molecular biomarkers for AMI have been established, including creatine kinase-MB, 20 myoglobin, 21 cardiac troponin T (cTnT), 22 and cardiac troponin I (cTnI). 23 Clinical medical assay demonstrated that once a cardiac injury occurs, the level of cTnI in the human blood rises rapidly within 3−4 h. 24,25 Thus, cTnI has been accepted as a "golden-standard" biomarker for the diagnosis of AMI by the European Society of Cardiology, 26 the American College of Cardiology, 27 and the Chinese Society of Laboratory Medicine. 28 Therefore, the development of rapid, accurate, and sensitive POCT for cTnI is of considerable importance in the diagnosis in the early development, prognosis, and monitoring of AMI.…”

Section: Introductionmentioning

confidence: 99%

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Immunoaffinity-Induced Signal Depression of Cu-MOF-74 for Label-Free Electrochemical Detection of Cardiac Troponin I

et al. 2022

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The unique chemical and physical properties of metal−organic frameworks (MOFs) endow them with promising applications in the electrochemical sensing field. Herein, a novel label-free electrochemical sensing strategy for cardiac troponin I (cTnI) has been constructed on the basis of immunoaffinityinduced depression of the electrochemical signal of Cu-MOF-74. The electrochemical assay shows that the immunoaffinity reaction between cTnI and anti-cTnI on the electrode surface can effectively inhibit the electrochemical signal of electrode-confined Cu-MOF-74, suggesting that the Cu-MOF-74-based interface may find application in the label-free analysis of cTnI. Thus, Cu-MOF-74 acts as a bifunctional material in this strategy, namely, the immobilization matrix of probe molecules and the signal source of the sensing analysis. In addition, the reason for the electrochemical signal depression of Cu-MOF-74 induced by immunoaffinity reaction is attributed to the increase in the insulation layer and the blocking of the electrolyte diffusion from the bulk solution to the electrode surface. In this strategy, the analytical range of cTnI is from 0.01 pg mL −1 to 1.0 ng mL −1 and the detection limit is 4.5 fg mL −1 . The Cu-MOF-74-based sensing interface is also reliable for cTnI analysis in real serum samples, showing that the biosensor has promising application in point-of-care testing (POCT) of myocardial injury-related diseases.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immunoaffinity-Induced Signal Depression of Cu-MOF-74 for Label-Free Electrochemical Detection of Cardiac Troponin I

et al. 2022

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“…Compared with other sensing systems referred by Jia et al (2020 ), the PMO 12 -MoS 2 / β -FeOOH@Au modified electrode (as listed in Table 4 ) had superior sensing performance toward miRNA-21 with an incredible detection limit of 0.11 fM, a broad linear range from 1 fM to 5 nM, high selectivity, good stability (15 days), excellent reproducibility, and acceptable feasibility. Bao et al (2020a ) also reported a photoelectrochemical sensor based on the matrix FeOOH/Bi 2 S 3 /AuNPs and using the hedgehog-shape{Mo 368 } cluster as an electron donor for the ultrasensitive detection of cardiac troponin I (cTnI). Combined {Mo 368 }/FeOOH/Bi 2 S 3 /AuNPs with the specific recognition of antigen and antibody, a novel sensor based on a modified ITO, and listed in Table 4 as {Mo 368 }/FeOOH/Bi 2 S 3 /AuNPs@ITO, was constructed, showing a wide detection range of 1.00 pg ml −1 –100 ng ml −1 and a low detection limit (0.76 pg ml −1 ).…”

Section: Polyoxometalates Functionalized Sensorsmentioning

confidence: 99%

Polyoxometalate Functionalized Sensors: A Review

2022

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Polyoxometalates (POMs) are a class of metal oxide complexes with a large structural diversity. Effective control of the final chemical and physical properties of POMs could be provided by fine-tuning chemical modifications, such as the inclusion of other metals or non-metal ions. In addition, the nature and type of the counterion can also impact POM properties, like solubility. Besides, POMs may combine with carbon materials as graphene oxide, reduced graphene oxide or carbon nanotubes to enhance electronic conductivity, with noble metal nanoparticles to increase catalytic and functional sites, be introduced into metal-organic frameworks to increase surface area and expose more active sites, and embedded into conducting polymers. The possibility to design POMs to match properties adequate for specific sensing applications turns them into highly desirable chemicals for sensor sensitive layers. This review intends to provide an overview of POM structures used in sensors (electrochemical, optical, and piezoelectric), highlighting their main functional features. Furthermore, this review aims to summarize the reported applications of POMs in sensors for detecting and determining analytes in different matrices, many of them with biochemical and clinical relevance, along with analytical figures of merit and main virtues and problems of such devices. Special emphasis is given to the stability of POMs sensitive layers, detection limits, selectivity, the pH working range and throughput.

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“…There are also composite materials by using other materials as the substrate including Au–Pd/MnO 2 , FeOOH/Bi 2 S 3 /Au, and so on. − …”

Section: States Of Art On Clinically Oriented Biosensors For Troponin...mentioning

confidence: 99%

Progress, Opportunities, and Challenges of Troponin Analysis in the Early Diagnosis of Cardiovascular Diseases

Zhang

et al. 2021

Anal. Chem.

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Cardiac troponin I photoelectrochemical sensor: {Mo368} as electrode donor for Bi2S3 and Au co-sensitized FeOOH composite

Cited by 28 publications

References 49 publications

Immunoaffinity-Induced Signal Depression of Cu-MOF-74 for Label-Free Electrochemical Detection of Cardiac Troponin I

Immunoaffinity-Induced Signal Depression of Cu-MOF-74 for Label-Free Electrochemical Detection of Cardiac Troponin I

Polyoxometalate Functionalized Sensors: A Review

Progress, Opportunities, and Challenges of Troponin Analysis in the Early Diagnosis of Cardiovascular Diseases

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