Cardiac troponin T in forensic autopsy cases

Remmer, S.; Kuudeberg, Anne; Tõnisson, Mailis; Lepik, Delia; Väli, Marika

doi:10.1016/j.forsciint.2013.09.010

Cited by 21 publications

(26 citation statements)

References 24 publications

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“…On the other hand, the possible influence of postmortem interval on troponin concentrations in postmortem samples has been repeatedly investigated in the past, with erratic results at times. For instance, Zhou et al [19,20,23], Remmer et al [30], and Chen et al…”

Section: Discussionmentioning

confidence: 99%

Cardiac troponins and NT-proBNP in the forensic setting: Overview of sampling site, postmortem interval, cardiopulmonary resuscitation, and review of the literature

Palmière

Tettamanti

Bonsignore

et al. 2018

Forensic Science International

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The possible use of biochemical markers in the postmortem diagnosis of myocardial ischemia is well known in the forensic setting, though several issues have limited its widespread adoption. The study presented herein focuses of N-terminal pro-B-type natriuretic peptide, troponin T, and troponin I, and the possible influence due to sampling site chosen, postmortem interval elapsed, and cardiopulmonary resuscitation attempts. Comparisons were performed between antemortem serum levels of these markers and postmortem levels measured in pericardial fluid and postmortem serum samples obtained from different sampling sites (n=16). Levels of these markers were also compared in cases characterized by various postmortem intervals (n=48, consisting of 24 ischemic heart disease cases and 24 controls) as well as in cases with and without cardiopulmonary resuscitation (n=22, consisting of 14 cases of hanging and 8 cases of drug intoxication). Our results indicate that N-terminal pro-B-type natriuretic peptide, troponin T, and troponin I values determined in postmortem serum from femoral blood (collected up to 24h after death) do not differ significantly from those measured in venous blood antemortem serum samples (collected at the upper limbs). In addition, our results reveal that the time elapsed after death should always be taken into consideration when cardiac troponins are measured in postmortem samples. Lastly, our findings reveal the absence of statistically significant differences between levels of the tested biomarkers (in postmortem serum from femoral blood) in cases without cardiopulmonary resuscitation compared to cases with cardiopulmonary resuscitation (at least for postmortem intervals up to 24h).

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Section: Discussionmentioning

confidence: 99%

Cardiac troponins and NT-proBNP in the forensic setting: Overview of sampling site, postmortem interval, cardiopulmonary resuscitation, and review of the literature

Palmière

Tettamanti

Bonsignore

et al. 2018

Forensic Science International

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“…The troponin in pericardial fluid seems to show a better negative predictive value for post-mortem investigations than serum. This has been raised regarding the old troponin assay [14,16,17], as well as in the single post-mortem evaluation of hs-TnT assay [25]. The hs-TnT levels found in this study were measured only in serum samples and the evaluation of the hs-TnT levels in pericardial fluid for the post-mortem diagnosis of IHD would be interesting in future studies.…”

Section: Discussionmentioning

confidence: 89%

“…Many clinical cardiac biomarkers were tested in post-mortem examination [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. The postmortem experimental use of the old cTn assay started early already in the 2000s.…”

Section: Introductionmentioning

confidence: 99%

High-sensitive cardiac troponin hs-TnT levels in sudden deaths related to atherosclerotic coronary artery disease

Beausire

Faouzi

Palmière

et al. 2018

Forensic Science International

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“…Several authors analyzed the importance of cardiac biomarkers in the post-mortem diagnosis of the acute myocardial infarction, and concluded that it is worth noticing that increased levels of these markers can also be seen in other causes of death in the practice of forensic medicine, such as hyperthermia, methamphetamine abuse, carbon monoxide poisoning, electrocution, pulmonary embolism, end-stage chronic renal disease, and cerebrovascular disease [24][25][26][27]. In addition, normal levels of cardiac biomarkers can not exclude the possibility of sudden cardiac death, because they can not be detected earlier than approximatively 3 hours after the myocardial injury [28].…”

Section: Resultsmentioning

confidence: 99%

Biochemical Markers of Sudden Cardiac Death

2020

Rev.Chim.

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The possible use of biochemical markers in the postmortem diagnosis of sudden cardiac deaths is well known in the forensic setting, though several issues have limited its widespread adoption. The aim of the present study was to describe the discovery of cardiac troponin I (cTnI), myoglobin (MYO) and creatinine kinase MB (CK-MB) in femoral whole blood (FWB), pericardial fluid (PF) and vitreous humor (VH) samples, that were collected post-mortem, in various cases of death related to ischemic heart disease, using the rapid diagnostic test 'Cardiac Markers Combo Rapid Test Device'. The authors conducted a prospective study in which they analyzed a total of 100 autopsies performed at the Legal Medicine Clinical Service of Galați County. The results of the present study showed that cardiac markers can be determined using rapid diagnostic tests for blood from the femoral vein and pericardial fluid, but not for the vitreous humor. Using postmortem biochemical markers of myocardial ischaemia requires caution and flexibility, so that the forensic pathologist has to take into consideration, when interpreting the results, both the postmortem interval, and the type of biological sample. Keywords: sudden death, cardiac, markers, troponin, forensic pathology

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Cardiac troponin T in forensic autopsy cases

Cited by 21 publications

References 24 publications

Cardiac troponins and NT-proBNP in the forensic setting: Overview of sampling site, postmortem interval, cardiopulmonary resuscitation, and review of the literature

Cardiac troponins and NT-proBNP in the forensic setting: Overview of sampling site, postmortem interval, cardiopulmonary resuscitation, and review of the literature

High-sensitive cardiac troponin hs-TnT levels in sudden deaths related to atherosclerotic coronary artery disease

Biochemical Markers of Sudden Cardiac Death

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