High-sensitive cardiac troponin hs-TnT levels in sudden deaths related to atherosclerotic coronary artery disease

Abstract

The measurement of hs-TnT serum values might be considered as an ancillary tool for the evaluation of death related to IHD, while taking necessary precautions in the interpretation of the results.

<p>Biomarkers in acute myocardial infarction: current perspectives</p>

“…Also other candidate biomarkers, such as hFABP, GPBB, S100, PAPP-A, CRP, TNF, IL6, IL18, CD40 ligand, MPO, MMP9, cell-adhesion molecules, oxidized LDL, glutathione, homocysteine, fibrinogen, and D-dimer procalcitonin may play a role in the diagnosis of AMI. Many of these candidate-markers result obtained with hFABP, S100A 1 protein, fibrinogen, or others in the myocardial tissue of subjects dead from myocardial ischemia (by immunohistochemistry) were also analyzed in forensic literature to obtain a better diagnosis of early evolving MI 64–66…”

Diagnostic Roles of Postmortem cTn I and cTn T in Cardiac Death with Special Regard to Myocardial Infarction: A Systematic Literature Review and Meta-Analysis

“…For the postmortem cTn I levels in serum, five of the included 13 studies (Pérez-Cárceles et al, 2004 [27]; Martínez Díaz et al, 2005 [28]; Batalis et al, 2010 [30]; Sun et al, 2011 [31]; and Carvajal-Zarrabal et al, 2017 [35]) compared the differences between the cardiac death and control groups, of which, four studies (Pérez-Cárceles et al, 2004 [27]; Martínez Díaz et al, 2005 [28]; Batalis et al, 2010 [30]; and Sun et al, 2011 [31]) recruited patients who died of myocardial infarction. For the postmortem cTn T levels in serum, senen of the included 13 studies (Zhu et al, 2003 [25]; Ellingsen et al, 2004 [26]; Khalifa et al, 2006 [29]; Remmer et al, 2013 [32]; Carvajal-Zarrabal et al, 2017 [35]; Beausire et al, 2018 [36]; and Rahimi et al, 2018 [24]) focused on the comparisons of postmortem cTn T concentrations in serum between the cardiac death and noncardiac death groups, and four of the seven studies (Zhu et al, 2003 [25]; Ellingsen et al, 2004 [26]; Khalifa et al, 2006 [29]; and Rahimi et al, 2018 [24]) used cases in which the patients died of myocardial infarction (Table 2).…”

Postoperative high-sensitivity troponin T as a predictor of sudden cardiac arrest in patients undergoing cardiac surgery

“…To date, numerous publications have demonstrated a significant relationship between higher troponin values and worse prognosis in patients with acute myocardial infarction, heart failure or severe aortic valve disease [9][10][11][12][13]. It has also been described that TnT is a predictor of cardiac death in patients with CAD, atrial fibrillation or impaired left ventricular function [17][18][19][20][21]. However, Rahimi et al [22] did not show a significant correlation between postmortem TnT level and sudden death.…”