Cardiac valve calcification is associated with mortality in hemodialysis patients: a retrospective cohort study

Bai, Jiuxu; Zhang, Aihong; Zhang, Yanping; Ren, Kaiming; Ren, Zhuo; Zhao, Chen; Wang, Qian; Cao, Ning

doi:10.1186/s12882-022-02670-5

Cited by 9 publications

(10 citation statements)

References 33 publications

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“…), we found that CVC was an independent risk factor for all-cause mortality but not cardiovascular mortality in IHD patients, with an HR of 2.14. Our findings are consistent with previous studies about all-cause mortality, but cardiovascular mortality was not significantly higher in the CVC group, which is inconsistent with Bai’s study [ 15 ]. There may be several reasons: Bai’s study enrolled more MHD patients (434) with much longer dialysis durations than our patients (3.29 ~ 3.58 years vs. 1.45 ~ 1.83 years).…”

Section: Discussionsupporting

confidence: 54%

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Predictive role of cardiac valvular calcification in all-cause mortality of Chinese initial haemodialysis patients: a follow-up study of 4 years

Cheng

Cao

et al. 2023

BMC Nephrol

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Background Cardiac valvular calcification (CVC) is prevalent in haemodialysis (HD) patients. Its association with mortality in Chinese incident haemodialysis (IHD) patients remains unknown. Methods A total of 224 IHD patients who had just begun HD therapy at Zhongshan Hospital, Fudan University, were enrolled and divided into two groups according to the detection of cardiac valvular calcification (CVC) by echocardiography. The patients were followed for a median of 4 years for all-cause mortality and cardiovascular mortality. Results During follow-up, 56 (25.0%) patients died, including 29 (51.8%) of cardiovascular disease. The adjusted HR related to all-cause mortality was 2.14 (95% CI, 1.05–4.39) for patients with cardiac valvular calcification. However, CVC was not an independent risk factor for cardiovascular mortality in patients who had just begun HD therapy. Conclusion CVC at baseline is an independent risk factor for all-cause mortality in HD patients and makes an independent contribution to the prediction of all-cause mortality. These findings support the use of echocardiography at the beginning of HD.

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Section: Discussionsupporting

confidence: 54%

“…CVC is regarded as an age-related degenerative disorder with little impact on heart function. Although CVC has little effect on the general population, it is an independent risk factor for all-cause mortality and cardiovascular mortality in ESRD and MHD patients [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Predictive role of cardiac valvular calcification in all-cause mortality of Chinese initial haemodialysis patients: a follow-up study of 4 years

Cheng

Cao

et al. 2023

BMC Nephrol

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“…Following the inclusion criteria, 22 (12,(15)(16)(17)(18)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) articles were eventually included in our study. The study selection process is depicted in Figure 1.…”

Section: Baseline Characteristics Of the Included Studiesmentioning

confidence: 99%

“…The study selection process is depicted in Figure 1. Among those including articles, 13 studies only reported associated factors for development of CVC, while the other 9 (15)(16)(17)(18)(38)(39)(40)(41)(42) studies also explored the association of CVC and mortality meanwhile. Patients treated with hemodialysis were enrolled in 9 studies, while patients treated with peritoneal dialysis were enrolled in 6 studies.…”

Section: Baseline Characteristics Of the Included Studiesmentioning

confidence: 99%

Associated factors of cardiac valve calcification and its prognostic effects among patients with chronic kidney disease: a systematic review and meta-analysis

Zhang

Pang

Wang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundCardiac valve calcification (CVC) is highly prevalent and a risk factor for adverse outcomes in patients with chronic kidney disease (CKD). This meta-analysis aimed to investigate the risk factors for CVC and association between CVC and mortality in CKD patients.MethodThree electronic databases including PubMed, Embase, and Web of Science were searched for relevant studies up to November 2022. Hazard ratios (HR), odds ratios (OR), and 95% confidence intervals (CI) were pooled using random-effect meta-analyses.Results22 studies were included in the meta-analysis. Pooled analyses showed that CKD patients with CVC were relatively older, had a higher body mass index, left atrial dimension, C-reaction protein level, and a declined ejection fraction. Calcium and phosphate metabolism dysfunction, diabetes, coronary heart disease, and duration of dialysis were all predictors for CVC in CKD patients. The presence of CVC (both aortic valve and mitral valve) increased the risk of all-cause and cardiovascular mortality in CKD patients. However, the prognostic value of CVC for mortality was not significant anymore in patients with peritoneal dialysis.ConclusionCKD patients with CVC had a greater risk of all-cause and cardiovascular mortality. Multiple associated factors for development of CVC in CKD patients should be taken into consideration by healthcare professionals to improve prognosis.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier [CRD42022364970].

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“…The C-STRIDE study analyses showed that AAC may be associated with the risk of death for patients with CKD of any severity, while CVC is a possible risk factor for cardiovascular disease but only among those patients with mild to moderate CKD in the Chinese cohort [ 25 ]. Our previous study found that CVC increased the risk of all-cause and cardiovascular mortality among HD patients [ 26 ]. We sought to investigate the contributions of AAC and CVC to adverse events by using the partial chi-square statistic minus the predictor degrees of freedom [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Abdominal aortic calcification score can predict all-cause and cardiovascular mortality in maintenance hemodialysis patients

Bai

Zhang

et al. 2023

Renal Failure

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Purpose: Abdominal aortic calcification (AAC) assessed by using standard lateral lumbar radiographs can be graded, and composite summary scores (range, 0–24) have been shown to be highly predictive of subsequent cardiovascular morbidity and mortality in hemodialysis (HD) patients. However, few studies have sought to determine the optimal AAC score cutoff values for the prediction of mortality among HD patients. Methods: This retrospective cohort study included 408 hemodialysis patients. AAC severity was quantified by the AAC score, which was measured by lateral lumbar radiography with complete follow-up data from January 2015 to December 2021. We used receiver operating characteristic (ROC) analysis to find the cutoff AAC value for the prediction of mortality. The Kaplan–Meier method was used to analyze all-cause and cardiovascular mortality. Results: The cutoff calcification score for the prediction of mortality was 4.5 (sensitivity, 67.3%; specificity, 70.4%). The patients with AAC scores above 4.5 had significantly higher all-cause (log-rank p < 0.001) and cardiovascular (log-rank p < 0.001) mortality rates than those with AAC scores below 4.5. In the multivariate regression analyses, an AAC score above 4.5 was a significant factor associated with all-cause mortality (HR: 2.079, p = 0.002) and cardiovascular mortality (HR: 2.610, p < 0.001). Conclusions: AAC is a reliable aortic calcification marker. HD patients with an AAC score > 4.5 have significantly elevated all-cause and cardiovascular mortality compared with those with an AAC score ≤ 4.5. AAC was a better predictor than cardiac valve calcification for mortality in HD patients.

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Cardiac valve calcification is associated with mortality in hemodialysis patients: a retrospective cohort study

Cited by 9 publications

References 33 publications

Predictive role of cardiac valvular calcification in all-cause mortality of Chinese initial haemodialysis patients: a follow-up study of 4 years

Predictive role of cardiac valvular calcification in all-cause mortality of Chinese initial haemodialysis patients: a follow-up study of 4 years

Associated factors of cardiac valve calcification and its prognostic effects among patients with chronic kidney disease: a systematic review and meta-analysis

Abdominal aortic calcification score can predict all-cause and cardiovascular mortality in maintenance hemodialysis patients

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