Cardio-ankle vascular stiffness index (CAVI) and 24 h blood pressure profiles

Grillo, Andrea; Lonati, Laura; Guida, Valentina; Parati, Gianfranco

doi:10.1093/eurheartj/suw060

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…This approach is relatively independent of both BP and heart rate and is easy to use and reproducible 26,27 . CAVI has been shown to be associated with BP variability, 28,29 and elevated values have been reported in patients with hypertension and diabetes mellitus 30 . Preclinical data indicate a potential for SGLT2 inhibitors to improve arterial stiffness 31,32 .…”

Section: Discussionmentioning

confidence: 99%

Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study

Kario

Okada

Murata³

et al. 2020

J of Clinical Hypertension

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Section: Discussionmentioning

confidence: 99%

Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study

Kario

Okada

Murata³

et al. 2020

J of Clinical Hypertension

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“…This impairment of baroreflex could be explained by a reduced stretching of the arterial baroreceptors in the aortic arch and carotid arteries caused by increased stiffness of these large arteries. 24 , 26 Moreover, stroke volume increase induced by neurohumoral changes occurring in the morning could directly favor a rapid increase of (mainly systolic) BP when the buffering capacity of large arteries is reduced due to increased stiffness. Considering more broadly this complex interplay, MBPS might thus be considered as a manifestation of the generally increased susceptibility of BP to undergo short-term fluctuations, reflected by measures of short-term BP variability.…”

Section: Pathophysiology Of Mbpsmentioning

confidence: 99%

Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects

Bilo¹,

Grillo²,

Guida³

et al. 2018

IBPC

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Morning hours are the period of the day characterized by the highest incidence of major cardiovascular events including myocardial infarction, sudden death or stroke. They are also characterized by important neurohormonal changes, in particular, the activation of sympathetic nervous system which usually leads to a rapid increase in blood pressure (BP), known as morning blood pressure surge (MBPS). It was hypothesized that excessive MBPS may be causally involved in the pathogenesis of cardiovascular events occurring in the morning by inducing hemodynamic stress. A number of studies support an independent relationship of MBPS with organ damage, cerebrovascular complications and mortality, although some heterogeneity exists in the available evidence. This may be due to ethnic differences, methodological issues and the confounding relationship of MBPS with other features of 24-hour BP profile, such as nocturnal dipping or BP variability. Several studies are also available dealing with treatment effects on MBPS and indicating the importance of long-acting antihypertensive drugs in this regard. This paper provides an overview of pathophysiologic, methodological, prognostic and therapeutic aspects related to MBPS.

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“…Параметр β в расчетах делает CAVI независимым от значений АД во время измерения. В целом CAVI представляет собой глобальный индекс как центральной, так и периферической жесткости, и, таким образом, является подходящим кандидатом для рутинной оценки сосудистого повреждения и для расчета риска ССЗ [46].…”

Section: оценка сосудистого возрастаunclassified

The Concept of Early Vascular Aging

Burko

Avdeeva

Олейников

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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The age is one of the main non-modified factors which reduces the elasticity of vessels and increases the appearance of atherosclerotic plaques. A number of studies have revealed that in some people, vascular changes occur at a younger age, while the presence of only classical risk factors does not explain the development of cardiovascular events in young people. This phenomenon is described as a syndrome of early, or accelerated, vascular aging (EVA). Aspects of this premature process include endothelial dysfunction, increased arterial stiffness, thickening of the intima-media complex and impaired dilatation of the central arteries, an increase of the reflected wave, hypertrophy of small vessels with a decrease in their lumen. Accelerated aging of the vascular wall increases the frequency of complications, therefore, recently "vascular age” is considered as an important predictor of individual risk of cardiovascular events. The review describes factors and mechanisms that trigger the process of EVA, genetic aspects of vascular damage and the biology of telomeres. Changes in hemodynamics and structural and functional properties of arteries during physiological and accelerated aging are presented. Currently, several indicators have been proposed that indicate arterial wall damaging and progression of vascular aging. The carotid-femoral pulse wave velocity is included in the list of indicators of subclinical target organs damage in ESH-ESC Guidelines for the management of arterial hypertension. The results of studies on the developing the new diagnostic markers for identifying individuals with "normal" or "early" ("accelerated") vascular aging are presented. Therapeutic strategies are aimed at decreasing the influence of factors that provoke EVA and include a non-pharmacological approach and medical intervention. The paper describes methods of therapeutic correction of the EVA syndrome.

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Cardio-ankle vascular stiffness index (CAVI) and 24 h blood pressure profiles

Cited by 9 publications

References 43 publications

Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study

Effects of luseogliflozin on arterial properties in patients with type 2 diabetes mellitus: The multicenter, exploratory LUSCAR study

Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects

The Concept of Early Vascular Aging

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