Cardio-metabolic benefits of quercetin in elderly patients with metabolic syndrome

Shatylo, V. B.; Antoniuk-Shcheglova, I. A.; Naskalova, Svitlana; Bondarenko, Olena; Havalko, Anna; Krasnienkov, Dmytro; Zabuga, O. G.; Kukharskyy, Vitaliy; Guryanov, Vitaly; Vaiserman, Alexander

doi:10.1016/j.phanu.2020.100250

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…Recently, there is a randomized, placebo-controlled trial investigating the effect of quercetin on different aspects of MetS in elderly patients. The results revealed that administration of 240 mg/day quercetin for 3 months led to a significant decrease in body weight, BMI, systolic and diastolic blood pressure, levels of total cholesterol and LDL-cholesterol, fasting plasma insulin and 2-hour glucose levels, confirming the effectiveness of quercetin on MetS components ( Shatylo et al, 2021 ). In addition, many preclinical and clinical studies have indicated the effects of quercetin on the prevention and treatment of CVD and suggested due to its antioxidant, anti-inflammatory, antidiabetic, antidyslipidemic, antihypertension, antiapoptotic, anti-atherosclerotic, and antiplatelet activities ( Mirsafaei et al, 2020 ).…”

Section: Effects Of Quercetin In Hyperuricemia and Gouty Arthritismentioning

confidence: 72%

A review on benefits of quercetin in hyperuricemia and gouty arthritis

Nutmakul

2022

Saudi Pharmaceutical Journal

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Section: Effects Of Quercetin In Hyperuricemia and Gouty Arthritismentioning

confidence: 72%

A review on benefits of quercetin in hyperuricemia and gouty arthritis

Nutmakul

2022

Saudi Pharmaceutical Journal

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“…The percentage of examinees with carbohydrate metabolism prediabetic disorders also decreased. The obtained effect may be due to the action of the antioxidant Q, which in previous studies normalized the increased level of glucose in the blood and reduced insulin resistance [5,7,9]. Another study showed that the use of IONs also normalized glucose homeostasis in experimental type II diabetes animals [15].…”

Section: Resultsmentioning

confidence: 99%

“…Previous experimental and clinical studies have shown a positive effect of the antioxidant Q on various MS manifestations, in particular, a decrease in the glycemia level, total cholesterol (CHL) and low-density lipoprotein cholesterol (LDL-C), improvement of endothelial function, additional blood pressure reduction, inflammatory markers reduction, a decrease of indicators blood viscosity, and platelet aggregation ability [5][6][7][8][9].…”

mentioning

confidence: 99%

Positive effects of Quercetin, Iron Oxide Nanoparticles and Ascorbic Acid composition in the treatment of women with metabolic syndrome

Shatilo

Antoniuk-Shcheglova

Naskalova

et al. 2023

A&L

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Relevance of study. Metabolic syndrome (MS) increases the risk of atherosclerotic cardiovascular disease and type ІІ diabetes. Correction of the MS manifestations is important for reducing cardiovascular risk. Aim - to study the effects of using a composition consisting of quercetin (Q), polyvalent iron oxide nanoparticles (IONs) and ascorbic acid (AA) in women with MS. Materials and methods. 60 women with MS took part in the study. They were divided equally into two groups. The control group patients received a placebo for one month, and the main group received a composition of Q, IONs and AA for one month too. Anthropometric parameters, fasting plasma glucose level and standard oral glucose tolerance test (OGTT), serum lipid concentration, and microvascular endothelial function in a sample with reactive post-occlusion hyperemia were determined. Results. The use of the composition led to a decrease in the glycemia level of both on an empty stomach and after 2 hours of SGTT, the concentration of total cholesterol and low-density lipoproteins in blood serum in atherogenic dyslipidemia patients. At the same time, there was an improvement in the endothelium functional state of the microvessels, as evidenced by an increase in the maximum volume velocity of skin blood flow in the reactive hyperemia test. Conclusion. It was found that the use of a composition Q, IONs and AA had a positive effect on cardiovascular risk factors in MS patients. _________________________________________________________________________________________ Keywords: iron oxide nanoparticles; quercetin; metabolic syndrome; glucose and blood lipids; the microvascular endothelium function.

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“…Доведеною є корисність таких продуктів харчування, що містять поліфеноли, і, зокрема, кверцетин, що збільшує біодоступність оксиду азоту [31,32]. Кверцетин насамперед є скавенджером вільних радикалів та має здатність активувати ферменти власного антиоксидантного захисту організму.…”

Section: підходи до лікування окремих складових мсunclassified

Current Data on the Directions of Therapy of Essential Hypertension in Patients with Metabolic Syndrome and COVID-19 and Possibilities for Prevention of Long-Term Complications

Ivanytska¹,

Kazakov²,

Petrov³

et al. 2021

Ukr. ž. med. bìol. sportu

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The review article includes information on data on the treatment of patients with essential hypertension and manifestations of metabolic syndrome and their effectiveness in preventing the development of long-term complications of COVID-19. The pandemic of acute respiratory syndrome caused by SARS-CoV-2 requires changes in the approach to the treatment and prevention of metabolic syndrome and essential hypertension, as the presence of these comorbidities worsens the course and prognosis of infectious disease. Some pathogenetic links have been identified that affect these pathological conditions. Emphasis is placed on the key role of a balanced and healthy diet, as a component of a healthy lifestyle, in maintaining the optimal functional state of the cardiovascular system. It is also noted that the course of infectious disease caused by SARS-CoV-2 in patients with metabolic syndrome is more severe and more often leads to complications. Since COVID-19 is recognized as a multi-organ disease with a wide range of manifestations and long-term symptoms, data on the course of this disease in patients with hypertension and metabolic syndrome were analyzed. Endothelial dysfunction is highlighted as one of the pathogenetic links that combines essential hypertension, insulin resistance and atherosclerosis, and options for its correction are considered. Standards for the treatment of essential hypertension and metabolic syndrome in view of the COVID-19 pandemic are presented. Information on the ability of statins to increase glycemia with long-term use, especially in patients with metabolic syndrome, is given. Conclusion. A number of drugs that have antioxidant, vasodilator and anti-inflammatory properties that do not cause an increase in glycemia, including quercetin, have been proposed. Its positive effect on the level of blood pressure has been revealed, which implies its use as an adjunct to antihypertensive therapy. The combination of quercetin and vitamin C is considered as an adjunct to basic therapy for COVID-19 disease and its long-term complications. Further studies are planned to determine the clinical value of quercetin supplements in therapy of essential hypertension, rehabilitation of patients after COVID-19, stabilization of dyslipidemia and insulin resistance, as well as dose adjustment and study of possible drug interactions between quercetin and antihypertensive drugs

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Cardio-metabolic benefits of quercetin in elderly patients with metabolic syndrome

Cited by 17 publications

References 36 publications

A review on benefits of quercetin in hyperuricemia and gouty arthritis

A review on benefits of quercetin in hyperuricemia and gouty arthritis

Positive effects of Quercetin, Iron Oxide Nanoparticles and Ascorbic Acid composition in the treatment of women with metabolic syndrome

Current Data on the Directions of Therapy of Essential Hypertension in Patients with Metabolic Syndrome and COVID-19 and Possibilities for Prevention of Long-Term Complications

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