Cardiodynamic factors affecting hyperpnea during steady-state exercise in man.

Miyamoto, Yuri; Niizeki, Kyuichi; Kikuchi, Kôichi; Doi, Katsuhiko

doi:10.2170/jjphysiol.39.411

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…relation between V E and VCO 2 responses during exercise [6]. Interestingly, in experiments using anesthetized animals, Cross et al [7] and Weissman et al [8] demonstrated similar responses in the V E-V CO 2 relationship to electrically induced muscle contractions in the presence and absence of intact spinal cord transmission.…”

mentioning

confidence: 88%

VE Response to VCO2 during Exercise Is Unaffected by Exercise Training and Different Exercise Limbs.

Itoh

Fukuoka²,

Grassi³

et al. 2002

JJP

View full text Add to dashboard Cite

Recently, a change in pulmonary ventilation (V E) per unit change of carbon dioxide production (VCO 2 ) (i.e., V E-V CO 2 slope) can be measured readily from data routinely acquired during cardiopulmonary exercise testing and carries important prognostic information for chronic heart failure (CHF) patients with preserved exercise tolerance [1,2]. According to the "cardiodynamic" hypothesis, VE dynamics in the transient phase are mediated by the pulmonary vascular CO 2 flow to the lungs [3][4][5], and there is a strong cor- Japanese Journal of Physiology, 52, 489-496, 2002 Key words: ventilation, CO 2 output, leg exercise, arm exercise, exercise training. Abstract:We designed two experiments to investigate the relationship between ventilation (V E) and CO 2 output (V CO 2 ) during exercise under the conditions of exercising different limbs, the arms as opposed to the legs (experiment 1), and of different physical training states after undergoing standard exercise training for 90 d (experiment 2). Six healthy young subjects underwent submaximal ramp exercise at an incremental work rate of 15 W/min for the arm and leg, and 11 healthy middle-aged subjects underwent an incremental exercise test at the rate of 30 W/3 min before and after exercise training. We measured pulmonary breath-by-breath V E, V CO 2 , oxygen uptake (V O 2 ), tidal volume (VT), breathing frequency (bf), and end-tidal O 2 and CO 2 pressures (PET O 2 , PET CO 2 ) via a computerized metabolic cart. In experiment 1, arm exercise produced significantly greater V E than did leg exercise at the same work rates, as well as significantly higher V O 2 , V CO 2 , and bf. The slopes of the regression lines in the V E-V CO 2 relationship were not significantly different: the values were 27.8Ϯ2.1 (SD) during the arm exercise, and 25.3Ϯ3.9 during the leg exercise, with no differences in their intercepts. In experiment 2, the V O 2 , V CO 2 , and V E responses at the same work rates were similar in both before and after the 90-d exercise training, whereas the heart rate (HR) and mean blood pressure (MBP) were significantly reduced after training. Exercise training did not alter the V E-V CO 2 relationship, the slope of which was 31.9Ϯ4.9 before exercise training and 34.2Ϯ4.4 after exercise training. We concluded that the V E-V CO 2 relationship during exercise is unaltered, independent of not only working muscle regions but also exercise training states.

show abstract

mentioning

confidence: 88%

VE Response to VCO2 during Exercise Is Unaffected by Exercise Training and Different Exercise Limbs.

Itoh

Fukuoka²,

Grassi³

et al. 2002

JJP

View full text Add to dashboard Cite

show abstract

“… a Measurements reported in Johnson et al (), Reeves et al (), Donevan et al (), Åstrand et al (), Frick and Somer (), Tabakin et al (), Dagenais et al (), Damato et al (), Ekblom et al (), Ouellet et al (), Hermansen et al (), Jones et al (), Eriksson et al (), Pernow and Saltin (), Krone et al (), Zeidifard et al (), Sharma et al (), Kanstrup and Ekblom (), Hossack and Bruce (), Frostell et al (), Lewis et al (), Torre‐Bueno et al (), Wagner et al (), Bebout et al (), Miyamoto et al (), Podolsky et al (), Turley and Wilmore (), Rice et al (), Hopkins et al (), Sun et al (), McGuire et al (), Nottin et al (), Poole et al (), Vinet et al (), Gisolf et al (), Olfert et al (), Dibski et al (). b Percentiles based on a log–normal distribution according to the Anderson–Darling test performed on individual data.…”

Section: Resultsunclassified

Derivation of cardiac output and alveolar ventilation rate based on energy expenditure measurements in healthy males and females

Brochu¹,

Brodeur

Krishnan

2011

J of Applied Toxicology

View full text Add to dashboard Cite

Physiologically based pharmacokinetic modeling and occupational exposure assessment studies often use minute ventilation rates (VE), alveolar ventilation rates (VA) and cardiac outputs (Q) that are not reflective of the physiological variations encountered during the aggregate daytime activities of individuals from childhood to adulthood. These variations of VE, VA and Q values were determined for healthy normal-weight individuals aged 5-96 years by using two types of published individual data that were measured in the same subjects (n = 902), namely indirect calorimetry measurements and the disappearance rates of oral doses of deuterium (²H) and heavy-oxygen (¹⁸O) in urine monitored by gas-isotope-ratio mass spectrometry. Arteriovenous oxygen content differences (0.051-0.082 ml of O₂ consumed ml⁻¹ of blood) and ratios of the physiological dead space to the tidal volume (0.232-0.419) were determined for oxygen consumption rates (0.157-0.806 l min⁻¹) required by minute energy expenditures ranging from 0.76 to 3.91 kcal min⁻¹. Generally higher values for the 2.5th up to the 99th percentile for VE (0.132-0.774 l kg⁻¹ min⁻¹, 4.42-21.69 l m⁻² min⁻¹), VA (0.093-0.553 l kg⁻¹ min⁻¹, 3.09-15.53 l m⁻² min⁻¹), Q (0.065-0.330 l kg⁻¹ min⁻¹, 2.17 to 9.46 l m⁻² min⁻¹) and ventilation-perfusion ratios (1.12-2.16) were found in children and teenagers aged 5-<16.5 years compared with older individuals. The distributions of cardiopulmonary parameters developed in this study should be useful in facilitating a scientifically sound characterization of the inter-individual differences in the uptake and health risks of lipophilic air pollutants, particularly as they relate to younger children.

show abstract

Derivation of physiological inhalation rates in children, adults, and elderly based on nighttime and daytime respiratory parameters

Brochu

Brodeur

Krishnan

2011

Inhalation Toxicology

View full text Add to dashboard Cite

The methodology developed in our previous studies ( Brochu et al. 2006a-c ) for the determination of physiological daily inhalation rates was improved by integrating into the calculation process, both nighttime and daytime respiratory parameters, namely oxygen uptake factors (H) and ventilatory equivalents (VQ). H values during fasting (0.2057±0.0018 L of O2/kcal; mean±SD) and postprandial phases (0.2059±0.0019 L of O2/kcal) as well as VQ values for subjects at rest (27.4±4.8 to 32.2±3.1, unitless) and during the aggregate daytime activities (29.9±4.2 to 33.7±7.2) were determined and combined with published doubly labeled water measurements for the calculation of daily inhalation rates in normal-weight males and females aged 0.22-96 years (n=1235). Depending upon the unit value chosen, the highest 99th percentiles for inhalation data were found in males aged 35 to <45 years (35.40 m3/day), 2.6 to <6 months (1.138 m3/kg-day), and 10 to <16.5 years (22.29 m3/m2-day). Means and percentiles expressed in m3/kg-day as well as in m3/m2-day suggest generally higher intakes of air pollutants in children than in adults and in males than in females (in g/kg-day or g/m2-day) for identical exposure concentrations and conditions. For instance, means in boys aged 2.6 to <6 months of 10.99±3.50 m3/m2-day and 0.572±0.191 m3/kg-day are 1.3- and 2.5-folds higher, respectively, than those in adult males 65?96 years old (8.42±2.13 m3/m2-day, 0.225±0.059 m3/kg-day).

show abstract

Cardiodynamic factors affecting hyperpnea during steady-state exercise in man.

Cited by 3 publications

References 18 publications

VE Response to VCO2 during Exercise Is Unaffected by Exercise Training and Different Exercise Limbs.

VE Response to VCO2 during Exercise Is Unaffected by Exercise Training and Different Exercise Limbs.

Derivation of cardiac output and alveolar ventilation rate based on energy expenditure measurements in healthy males and females

Derivation of physiological inhalation rates in children, adults, and elderly based on nighttime and daytime respiratory parameters

Contact Info

Product

Resources

About