Cardiometabolic Health Outcomes Associated With Discordant Visceral and Liver Fat Phenotypes: Insights From the Dallas Heart Study and UK Biobank

Tejani, Sanaa; McCoy, Cody; Ayers, Colby; Powell‐Wiley, Tiffany M.; Després, Jean‐Pierre; Linge, Jennifer; Leinhard, Olof Dahlqvist; Petersson, Mikael; Borga, Magnus; Neeland, Ian J.

doi:10.1016/j.mayocp.2021.08.021

Cited by 35 publications

(37 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A reanalysis of the data by grouping the subjects from low IHTG‐Low VF to high IHTG‐high VF showed that insulin resistance is increased proportionally with both visceral and liver fat 31 . The importance of high VF regardless of high or low IHTG was also confirmed in a recent study that showed how VF was associated with higher risk of type 2 diabetes 39 . The preferential accumulation of fat and calories in visceral rather than subcutaneous fat, can be related to adipose tissue expansion, either by a combination of an increase in adipocyte number (hyperplasia), or size (hypertrophy).…”

Section: Discussionmentioning

confidence: 83%

“…31 The importance of high VF regardless of high or low IHTG was also confirmed in a recent study that showed how VF was associated with higher risk of type 2 diabetes. 39 The preferential accumulation of fat and calories in visceral rather than subcutaneous fat, can be related to adipose tissue expansion, either by a combination of an increase in adipocyte number (hyperplasia), or size (hypertrophy). While hyperplasia is associated with a beneficial and protective asset of adipose tissue, hypertrophy results in increased inflammation, macrophage infiltration, and reduced insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals

Saponaro

Sabatini

Gaggini

et al. 2022

Liver International

View full text Add to dashboard Cite

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous disorder, but the factors that determine this heterogeneity remain poorly understood.Adipose tissue dysfunction is causally linked to NAFLD since it causes intrahepatic triglyceride (IHTG) accumulation through increased hepatic lipid flow, due to insulin resistance and pro-inflammatory adipokines release. While many studies in NAFLD have looked at total adiposity (i.e. mainly subcutaneous fat, SC-AT), it is still unclear the possible impact of visceral fat (VF). Thus, we investigated how VF versus SC-AT was related to NAFLD severity in lean, overweight and obese individuals versus lean controls.Methods: Thirty-two non-diabetic NAFLD with liver biopsy (BMI 21.4-34.7 kg/m 2 ) and eight lean individuals (BMI 19.6-22.8 kg/m 2 ) were characterized for fat distribution (VF, SC-AT and IHTG by magnetic resonance imaging), lipolysis and insulin resistance by tracer infusion, free fatty acids (FFAs) and triglyceride (TAG) concentration and composition (by mass spectrometry).Results: Intrahepatic triglyceride was positively associated with lipolysis, adipose tissue insulin resistance (Adipo-IR), TAG concentrations, and increased saturated/unsaturated FFA ratio. Compared to controls VF was higher in NAFLD (including lean individuals), increased with fibrosis stage and associated with insulin resistance in liver, muscle and adipose tissue, increased lipolysis and decreased adiponectin levels.Collectively, our results suggest that VF accumulation, given its location close to the liver, is one of the major risk factors for NAFLD.Conclusions: These findings propose VF as an early indicator of NAFLD progression independently of BMI, which may allow for evidence-based prevention and intervention strategies.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals

Saponaro

Sabatini

Gaggini

et al. 2022

Liver International

View full text Add to dashboard Cite

show abstract

“…19 Linge et al reported that higher VAT, MFI, and liver fat but not ASAT were associated with coronary heart disease and type 2 diabetes, 20 which are also prospectively verified for VAT and liver fat. 21 In obese subjects, VAT and ASAT secrete, eg, inflammatory and immune compounds, and micro-RNAs, which can exert functional and pathophysiological alterations in various tissues. 19 In another FM cohort, we reported increased MFI in the quadriceps muscle despite no significant group differences in BMI.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical importance of these variables is emphasized by population-based data reporting that high VAT in combination with high or low liver fat are associated with atherosclerosis and increased risks for cardiovascular disease and type 2 diabetes. 21 Resting blood pressure shows a negative relationship with pain sensitivity (blood pressure -related hypoalgesia) -ie, it is a pain inhibitory mechanism in healthy subjects and may involve endogenous opioids and α 2 -adrenergic pathways. 110,[116][117][118] In chronic pain conditions including FM dysfunction of this mechanism has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables

Gerdle¹,

Leinhard²,

Lund³

et al. 2022

JPR

View full text Add to dashboard Cite

Background Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspects. Hitherto studies of FM have focused upon a surrogate for overall measure of fat content, ie, BMI. This study is motivated by that ectopic fat and adipose tissues are rarely investigated in FM including their relationships to physical capacity variables. Moreover, their relationships to clinical variables including are not known. Aims were to 1) compare body composition between FM and healthy controls and 2) investigate if significant associations exist between body composition and physical capacity aspects and important clinical variables. Methods FM patients (n = 32) and healthy controls (CON; n = 30) underwent a clinical examination that included pressure pain thresholds and physical tests. They completed a health questionnaire and participated in whole-body magnetic resonance imaging (MRI) to determine body composition aspects. Results Abdominal adipose tissues, muscle fat, and BMI were significantly higher in FM, whereas muscle volumes of quadriceps were smaller. Physical capacity variables correlated negatively with body composition variables in FM. Both body composition and physical capacity variables were significant regressors of group belonging; the physical capacity variables alone showed stronger relationships with group membership. A mix of body composition variables and physical capacity variables were significant regressors of pain intensity and impact in FM. Body composition variables were the strongest regressors of blood pressures, which were increased in FM. Conclusion Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients with FM.

show abstract

“…16,21,65 The mechanisms for ectopic fat accumulation in COPD have been associated with insulin resistance. 65 Thus, the probability of having Diabetes Type 2 increases in parallel with VAT accumulation, 16,21,66 while MFI excess increases the probability of cardiovascular comorbidities. 16,21 In contrast, a population-based cohort found no difference in the metabolic phenotype, including VAT, between COPD and controls.…”

mentioning

confidence: 99%

Skeletal Myosteatosis is Associated with Systemic Inflammation and a Loss of Muscle Bioenergetics in Stable COPD

Persson¹,

Sioutas²,

Kentson³

et al. 2022

JIR

View full text Add to dashboard Cite

Background: Common features among patients with more advanced chronic obstructive pulmonary disease (COPD) are systemic inflammation and a loss of both muscle mass and normal muscle composition. In the present study, we investigated COPD subjects to better understand how thigh muscle fat infiltration (MFI) and energy metabolism relate to each other and to clinical features of COPD with emphasis on systemic inflammation. Methods: Thirty-two Caucasians with stable COPD were investigated using questionnaires, lung function tests, blood analysis and magnetic resonance imaging (MRI) for analysis of body-and thigh muscle composition. Bioenergetics in the resting thigh muscle, expressed as the PCr/Pi ratio, were analysed using 31 phosphorus magnetic resonance spectroscopy ( 31 P-MRS). Results: Based on the combination of the MFI adjusted for sex (MFI a ) and the thigh fat-tissue free muscle volume, expressed as the deviation from the expected muscle volume of a matched virtual control group (FFMV vcg ), all COPD subjects displayed abnormally composed thigh muscles. Clinical features of increased COPD severity, including a decrease of blood oxygenation (r = −0.44, p < 0.05) and FEV 1 /FVC ratio, reflecting airway obstruction (r = −0.53, p < 0.01) and an increase of COPD symptoms (r = 0.37, p < 0.05) and breathing frequency at rest (r = 0.41, p < 0.05), were all associated with a raise of the PCr/Pi ratio in the thigh muscle. Increased MFI a of the thigh muscle correlated positively with markers of systemic inflammation (white blood cell count, r = 0.41, p < 0.05; fibrinogen, r = 0.44, p < 0.05), and negatively with weekly physical activity (r = −0.40, p < 0.05) and the PCr/Pi ratio in the resting thigh muscle (r = −0.41, p < 0.05). Conclusion:The present study implies a link between systemic inflammation, excessive MFI and a loss of bioenergetics in subjects with stable COPD.

show abstract

Cardiometabolic Health Outcomes Associated With Discordant Visceral and Liver Fat Phenotypes: Insights From the Dallas Heart Study and UK Biobank

Cited by 35 publications

References 36 publications

Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals

Adipose tissue dysfunction and visceral fat are associated with hepatic insulin resistance and severity of NASH even in lean individuals

Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables

Skeletal Myosteatosis is Associated with Systemic Inflammation and a Loss of Muscle Bioenergetics in Stable COPD

Contact Info

Product

Resources

About