Cardiomyopathy and Heart Failure in Aging

Retracted: Cardiac mitochondrial oxidative stress and dysfunction induced by arsenic and its amelioration by diallyl trisulphide

“…The elevated levels of lipid peroxidation products such as TBARs in the mitochondria may decrease the mitochondrial membrane fluidity, increase the negative surface charge distribution and alter the membrane ionic permeability including proton permeability, which uncouple oxidative phosphorylation. 2 Thus, accelerated lipid peroxidation damages both the mitochondrial structure and function of As treated rats, while pre-treatment of As exposed rats with DATS alters all these changes.…”

“…Toxic or pathological conditions, such as oxidative stress, that lead to an impairment of mitochondrial function, can increase the release of ROS. 2 As the main consumers of molecular oxygen in the cardiac cells, mitochondria play a central role in molecular events leading to tissue damage occurring in the condition of ischaemia. 3 The major cause of death worldwide is mainly related to the cardiovascular diseases.…”

Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association

“…The outer membrane is very similar to other cell membranes, with a 1:1 protein-to-lipid ratio; the most represented protein in the outer membrane is porin, an integral membrane protein facilitating inflow and outflow of small molecules [ 8 ].…”