Cardiopathogenicity of rapeseed oils and oil blends differing in erucic, linoleic, and linolenic acid content

McCutcheon, J; Umermura, T.; Bhatnagar, Maheep; Walker, Brian

doi:10.1007/bf02532900

Cited by 60 publications

(20 citation statements)

References 12 publications

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“…In contrast, myocardial Iesions found in male rats are often necrotic and fibrotic whether they have been fed a control diet, or a RSO high or low in erucic acid (Kramer et al . 1973;McCutcheon et al . 1976: Vles et al 1976;Hulan et al 1911a,b,c (Hulan et al 1977 c).…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Low Erucic Acid Rapeseed Oil Fed to Monkeys: Cardiac Lipids, Histochemistry and Pathology

Kramer¹,

Hulan²,

Procter³

et al. 1978

Can. J. Anim. Sci.

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Male and female cynomolgus monkeys (Macaca fascicularis), equally divided as to sex, were fed, up to 24 wk, diets which contained 20% by weight of either soybean oil or Brassica napus cv. Tower rapeseed oil which contained 0.2% erucic acid. Long-chain monoenes appeared to accumulate in the cardiac lipids of both sexes fed Tower rapeseed oil. Histochemical studies suggested no myocardial damage associated with the feeding of either diet. Histopathological examination of the hearts of monkeys fed the two diets showed that only two male monkeys fed soybean oil for 24 wk had myocardial lesions, and these were multiple small foci of mononuclear cells. The results indicate that Tower rapeseed oil is indistinguishable from soybean oil in its nutritional and pathological properties.

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Section: Methodsmentioning

confidence: 99%

Evaluation of Low Erucic Acid Rapeseed Oil Fed to Monkeys: Cardiac Lipids, Histochemistry and Pathology

Kramer¹,

Hulan²,

Procter³

et al. 1978

Can. J. Anim. Sci.

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“…Different authors [ 1 ] have indicated that car diovascular damage might be caused by di etary lipids. Thus, both linolenic (18:3 n-3) and erucic (22:1 n-9) acids have been ac cused of causing irrepairable damage in the cardiac tissue [2].…”

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Feeding Different Fats on Fatty Acid Composition of Major Individual Phospholipids of Rat Hearts

Ruiz-Gutiérrez

Molina²,

Vázquez³

1990

Ann Nutr Metab

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Comparative effects of feeding dietary linoleic (corn oil), oleic (olive oil), α-linolenic (soybean oil) and polyunsaturated fatty acids (fish oil) on lipid content and fatty acid composition of major individual phospholipids of rat hearts were examined. Feeding different diets did not result in lipid accumulation in the heart. Total triglyceride, nonesterified fatty acid, cholesteryl ester and phospholipid levels of heart tissue were not affected by the type of dietary fatty acid. However, heart free cholesterol levels decreased in both animals fed the olive and the fish oil diets. The percentage of individual phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and cardiolipin (CL) did not modify by changes in the dietary fat composition. Heart tissue from animals fed on olive oil were enriched with 18:1 (n-9 + n-7) fatty acid in all phospholipid fractions. Animals fed corn oil contained higher proportions of 18:2 (n-6) for PC, PE and CL, and the ingestion of the soybean oil diet increased 18:2 (n-6) for PC and CL in the same proportion as the ingestion of the corn oil diet. The levels of 22:6 (n-3) were increased in the fish oil-fed group, accompanied by both a decrease in total (n-6) fatty acids and an increase in total (n-3) fatty acids in the three phospholipid fractions. The 20:5 (n-3) was only detected in these animals. These results show that olive oil is as effective as fish oil in reducing heart cholesterol content and support earlier works suggesting the role of fish oil in preventing cardiovascular disease.

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“…The specific role of 18:3 n-3 of LEAR oil in the etiology of cardiac necrosis was postulated by McCutcheon et al (1976) and Trenholm et al (1979) Clandinin, 1980;McMurchie et aL, 1983;Rocquelin et aL, 1986;McMurchie, 1988). Preliminary results in our laboratory (Grynberg et al, 1984) …”

Section: Resultsmentioning

confidence: 98%

Relationship between lipid parameters and the occurrence and severity of lesions in the heart : a study on rats fed low erucic acid rapeseed oil

Rocquelin¹,

Juanéda²,

Astorg³

et al. 1989

Reprod. Nutr. Dévelop.

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Summary -Fifty-six male Wistar SPF rats were fed a diet containing low erucic acid rapeseed (LEAR) oil (15% by weight) as the only source of lipids for 18 wk. Lipid parameters (fatty acid composition and contents of lipid classes) and the occurrence and severity of focal lesions were both determined on the heart of each animal. Four groups were constituted according to the severity of cardiac lesions. Statistical analyses were applied to the data to find a relationship between the lipid parameters and the severity of heart lesions. None of the measured parameters (heart contents of neutral lipids, total phospholipids, phosphatidylcholine, phosphatidylethanolamine, diphosphatidylglycerol, sphingomyelin and fatty acid composition of each phospholipid class) appeared to be related with the grading of the lesions. Therefore, we failed to find a direct support for the assumption that heart lesions, induced by LEAR oil, are mediated by changes in the lipid and/or fatty acid composition of heart membranes. However, this hypothesis can not be discarded.

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Cardiopathogenicity of rapeseed oils and oil blends differing in erucic, linoleic, and linolenic acid content

Cited by 60 publications

References 12 publications

Evaluation of Low Erucic Acid Rapeseed Oil Fed to Monkeys: Cardiac Lipids, Histochemistry and Pathology

Evaluation of Low Erucic Acid Rapeseed Oil Fed to Monkeys: Cardiac Lipids, Histochemistry and Pathology

Comparative Effects of Feeding Different Fats on Fatty Acid Composition of Major Individual Phospholipids of Rat Hearts

Relationship between lipid parameters and the occurrence and severity of lesions in the heart : a study on rats fed low erucic acid rapeseed oil

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