Evaluation of Low Erucic Acid Rapeseed Oil Fed to Monkeys: Cardiac Lipids, Histochemistry and Pathology

Kramer, J. K. G.; Hulan, H. W.; Procter, B. G.; Róna, G; Mandavia, M. G.

doi:10.4141/cjas78-035

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…It should be noted, however, that other strains of rat, namely Chester Beatty (17,20) and Wistar (18), showed only a low incidence and/or severity of heart lesions which was not increased with the intake of LEAR oils. Similar results were observed with mice (18), pigs (21)(22)(23)(24)(25), monkeys (26,27), ducks (28), and chicken (29) fed LEAR oils.…”

Section: Discussionsupporting

confidence: 79%

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Kramer¹,

Hulan²,

Corner³

et al. 1979

Lipids

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The triglycerides of soybean oil were purified by molecular distillation and those of Tower rapeseed oil by molecular distillation and adsorption chromatography. The original oils and the purified triglycerides were incorporated in semisynthetic diets at 20% by weight and fed for 16 weeks to weanling male Sprague-Dawley rats to compare the nutritional and pathological effects of the oils and their triglyceride fractions on rats. The study was carried out at two independent laboratories. No significant differences were observed between the results of the two establishments. The incidence of myocardial lesions was significantly higher in rats fed Tower rapeseed oil than in those fed soybean oil. Purification of the triglycerides by molecular distillation and adsorption chromatography appeared to have no major effect on the incidence of myocardial lesions. This supports our previous findings that the cardiopathogenicity appeared to have no major effect on the incidence of myocardial lesions. This supports our previous findings that the cardiopathogenicity of the test oils to rats resides in the triglycerides of these oils.

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Section: Discussionsupporting

confidence: 79%

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Kramer¹,

Hulan²,

Corner³

et al. 1979

Lipids

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“…Interestingly, at 16 weeks the cardiac lipids of chickens fed Regular RSO contain considerably more of 20:1 and more 22:1 than those of the rat or pig. Similar to the pig (Friend et al, 1976;Ah erne et al, 1976) and monkey (Kramer et al, 1978), the chickens fed low 22:1 RSO's (Tower and Candle) in this study did not develop myocardial lesions as did the rats fed (Kramer et al, 1979), chickens (current study), pigs (Von U. Peterson et al, 1979), and monkeys (Beare-Rogers and Nera, 1972) fed diets containing rapeseed oil high in eicosenoic (12 to 14%) and erucic (25 to 30%) acids for different durations of time.…”

Section: C Q Cmentioning

confidence: 67%

“…The male rat is different from the pig and monkey with respect to the occurrence of myocardial lesions when high levels of these oils are fed (Kramer et al, 1978). Vogtmann et al (1973) demonstrated a decrease in body weight of chickens fed diets containing high levels of RSO high in 22:1, whereas the reverse was true with lard.…”

Section: Introductionmentioning

confidence: 89%

Growth, Heart Weight, Cardiac Lipid, and Pathology of Chickens Fed Soybean Oil or Oil Extracted from Different Rapeseed Cultivars

Hulan¹,

Corner²,

Nash³

et al. 1982

Poultry Science

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A total of 384 male Single Comb White Leghorn chicks of the Hyline strain were randomized in 24 Petersime battery units of 16 birds per unit. Four replicate pens were fed either a basal (control) diet containing no added oil or a diet supplemented with 20% by weight of either soybean oil or rapeseed oil (RSO) from cultivars Tower, Candle, Regular, or R-500. Levels of crucic acid (22:1) in the RSO's ranged from .1 to 51.6%. Four birds from each unit were killed at 4, 8, 12, and 16 weeks for cardiac lipid analysis and pathology. Feeding RSO had no consistent effect on body weights, heart weights, or the heart-to-body weight ratio. Only the diet containing R-500 (51.6% 22:1) consistently increased cardiac lipid levels as measured gravimetrically. Maximum deposition of the long-chain monoenes (22:1) and eicosenoic acids (20:1) occurred in the cardiac lipids by 8 weeks, and the levels remained high throughout the 16-week trial. The relative concentration of these long-chain monoenes in the cardiac lipids was positively correlated to the dietary levels of these acids. The incidence of lesions found in heart, liver, and skeletal muscle was significantly higher in chickens fed RSO's high in 22:1 than in chickens fed control or soybean oil, and the incidence significantly correlated to the level of 22:1 in the diet. The incidence of heart and muscle lesions and sinusoidal distention in chickens fed RSO's low in 22:1 was not significantly different from that of chickens fed the control diet or soybean oil, but the incidence of hepatic necrosis was significantly higher for chickens fed RSO's low in 22:1 compared to those fed the control diet or soybean oil.

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The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications

Sauer¹,

Kramer²

1980

Advances in Nutritional Research

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Evaluation of Low Erucic Acid Rapeseed Oil Fed to Monkeys: Cardiac Lipids, Histochemistry and Pathology

Cited by 14 publications

References 28 publications

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Cardiopathogenicity of soybean oil and tower rapessed oil triglycerides when fed to male rats

Growth, Heart Weight, Cardiac Lipid, and Pathology of Chickens Fed Soybean Oil or Oil Extracted from Different Rapeseed Cultivars

The Metabolism of Long-Chain Monoenoic Fatty Acids in Heart Muscle and Their Cardiopathogenic Implications

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