Cardiopatías estructurales y funcionales en pacientes adultos con inmunodeficiencia comun variable

Cambray-Gutiérrez, Julio César; Fernández-Muñoz, María de Jesús; Rivero-Hernández, Leonel Gerardo Del; López-Pérez, Patricia; Chávez-García, Aurora Alejandra; Segura-Méndez, Nora Hilda

doi:10.29262/ram.v62i2.69

Cited by 3 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Simultaneously, the composition of the host's microbiota is also regulated by the diet's Se. Therefore, pathogenic bacteria, microbiome, and cells of the host's immune system may be competing for a limited supply of selenium, which is of even more signi cant concern in patients with CVID [40][41][42].…”

Section: Discussionmentioning

confidence: 99%

Selenium-Related Nutritional Status in Patients With Common Variable Immunodeficiency: Association With Oxidative Stress and Atherosclerosis Risk

Andrade

Souza

Fonseca

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Common variable immunodeficiency (CVID) is an innate immunity error, possibly associated with recurrent or chronic infections and autoimmune / inflammatory diseases and neoplasms. It is suggested that these conditions lead to persistent immune stimulation and increased oxidative stress. A positive impact on the survival of patients with an inborn errors of immunity was observed with advanced clinical care protocols, thus raising concerns about the risk of developing other associated chronic diseases, such as atherosclerosis. Studies suggest that selenium (Se) is a protective trace element against damage caused by oxidative stress. Thus, it is postulated that adequate consumption reduces the risk of some chronic diseases. Results: The median age of CVID patients was 36.8 years, with a female predominance. Low concentrations of GPx, Se and apo A-1 were observed in the patients, besides the presence of dyslipidemia and higher concentrations of adiponectin, us-CRP, and LDLox. There was no association between the concentrations of Se and GPx and the biomarkers of lipid metabolism involved in atherosclerosis risk, except for a positive association with apo A-1 and HDL. The median of polyunsaturated fat was lower in CVID patients and the intake of zinc and retinol was higher among them when compared to controls. Conclusion: The study showed a higher risk of cardiovascular disease in CVID patients. The presence of low selenium in CVID patients points to the importance of assessing the selenium-related nutritional status in these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Selenium-Related Nutritional Status in Patients With Common Variable Immunodeficiency: Association With Oxidative Stress and Atherosclerosis Risk

Andrade

Souza

Fonseca

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The finding of peak systolic aortic pressure in high cutoff levels and mild valvular regurgitation in patients with CVID highlights the need for regular cardiac monitoring to control the sequels such as pulmonary arterial hypertension. 91 Murmur or cyanosis suggestive of congenital heart defects (particularly conotruncal anomalies) is associated with DGS, severe congenital neutropenia (SCN) type 4, CHARGE syndrome, Kabuki Syndrome, and MST1/STK4 deficiency. 1 , 10 , 16 , 33 G6PC3 deficiency could be characterized by a congenital heart disorder.…”

Section: Cardiacmentioning

confidence: 99%

Organ‐based clues for diagnosis of inborn errors of immunity: A practical guide for clinicians

Mohammadi

Yadegar

Mardani

et al. 2023

Immunity Inflam & Disease

View full text Add to dashboard Cite

Inborn errors of immunity (IEI) comprise a group of about 490 genetic disorders that lead to aberrant functioning or the development of distinct immune system components. So far, a broad spectrum of IEI‐related manifestations has been noted in the literature. Due to overlapping signs and symptoms of IEI, physicians face challenges in appropriately diagnosing and managing affected individuals. The last decade has witnesses improving in the molecular diagnosis of IEI patients. As a result, it can be the mainstay of diagnostic algorithms, prognosis, and possibly therapeutic interventions in patients with IEI. Furthermore, reviewing IEI clinical complications demonstrates that the manifestations and severity of the symptoms depend on the involved gene that causes the disease and its penetrance. Although several diagnostic criteria have been used for IEI, not every patient can be explored in the same way. As a result of the failure to consider IEI diagnosis and the variety of diagnostic capabilities and laboratory facilities in different regions, undiagnosed patients are increasing. On the other hand, early diagnosis is an almost essential element in improving the quality of life in IEI patients. Since there is no appropriate guideline for IEI diagnosis in different organs, focusing on the clues in the patient's chief complaint and physical exams can help physicians narrow their differential diagnosis. This article aims to provide a practical guide for IEI diagnosis based on the involved organ. We hope to assist clinicians in keeping IEI diagnosis in mind and minimizing possible related complications due to delayed diagnosis.

show abstract

Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk

et al. 2021

View full text Add to dashboard Cite

Background Common variable immunodeficiency (CVID) is an inborn errors of immunity, that leads to recurrent chronic infections and autoimmune/ inflammatory diseases and neoplasms. It is considered that these condition is related to persistent this immune-inflammatory stimulation and increased oxidative stress. A positive impact on the survival of patients with an inborn error of immunity was observed with advanced clinical care protocols, thus raising concerns about the risk of developing other associated chronic diseases, such as atherosclerosis. Studies suggest that selenium (Se) is a protective trace element against damage caused by oxidative stress. Thus, it is postulated that adequate consumption reduces the risk of some chronic diseases. Results Se median levels (ug/L) [45.6 (37.3–56.2) vs. 57.8 (46.0–66.0); p = 0.004] and GPX activity (U/L) [7682 (6548–8446) vs. 9284(8440–10,720); p = 0,002) were significantly lower in patients compared to controls. Inadequacy of Se levels was observed in 50% of the patients. There was a higher percentage of high values of C-reactive protein in the group of CVID patients compared to controls [8 (36.4%) vs. 2 (11.1%); p = 0.082]. Higher concentrations of oxidized LDL (45.3 mg/dL vs. 33.3 mg/dL; p = 0.016) and lower concentrations of Apo A-1 (98.5 mg/dL) vs. 117.0 mg/dL; p = 0.008) were observed in the CVID group compared to the control. There was a significant and positive correlation between Se plasma levels and apolipoprotein A-1 concentrations in CVID group (rho = 0.577; p = 0.001). Se values less than 46 μg / L (OR = 3.590; 95% CI 1.103 to 11.687; p = 0.034) and GPX activity below the 4th quartile (OR = 21.703; 95% CI 2.534 to 185.914; p = 0.005) were independently associated, after adjustment for age, overweight and dyslipidemia, with the CVID group (Table 5). Conclusion This study showed an higher percentage of high us-CRP, lower values of plasma Se and GPX activity, higher concentrations of LDLox and lower levels of Apo A-1 in CVID patients in comparison to controls, suggesting oxidative stress and cardiovascular risk.These data point to the importance of assessing the Se status and cardiovascular risk in these patients.

show abstract

Cardiopatías estructurales y funcionales en pacientes adultos con inmunodeficiencia comun variable

Cited by 3 publications

References 8 publications

Selenium-Related Nutritional Status in Patients With Common Variable Immunodeficiency: Association With Oxidative Stress and Atherosclerosis Risk

Selenium-Related Nutritional Status in Patients With Common Variable Immunodeficiency: Association With Oxidative Stress and Atherosclerosis Risk

Organ‐based clues for diagnosis of inborn errors of immunity: A practical guide for clinicians

Selenium-related nutritional status in patients with common variable immunodeficiency: association with oxidative stress and atherosclerosis risk

Contact Info

Product

Resources

About