Cardioprotective activity of iron oxide nanoparticles

Abstract

Iron oxide nanoparticles (IONPs) are chemically inert materials and have been mainly used for imaging applications and drug deliveries. However, the possibility whether they can be used as therapeutic drugs themselves has not yet been explored. We reported here that Fe2O3 nanoparticles (NPs) can protect hearts from ischemic damage at the animal, tissue and cell level. The cardioprotective activity of Fe2O3 NPs requires the integrity of nanoparticles and is not dependent upon their surface charges and molecules that were integrated into nanoparticles. Also, Fe2O3 NPs showed no significant toxicity towards normal cardiomyocytes, indicative of their potential to treat cardiovascular diseases.

Combining Nanomaterials and Developmental Pathways to Design New Treatments for Cardiac Regeneration: The Pulsing Heart of Advanced Therapies

“…Iron oxide nanoparticles have also been investigated as cardioprotective agents, as shown by Xiong et al (2015). The authors demonstrated the potential of maghemite NPs for protecting the heart from ischemic damage both in vivo and in vitro.…”

Nanozymes: a new choice for disease treatment

“…Brain injury repair mechanism of PtPdMo nanozyme with high catalytic activity and neutral environment preference [29] (color online) 图 3 Fe 2 O 3 @DMSA-NPs对大鼠冠状动脉结扎(CAL)损伤的保护作用 [32] (网络版彩图) Figure 3 Fe 2 O 3 @DMSA NPs protected coronary artery ligature (CAL) induced injury in rats [32] (color online) [39] (网络版彩图) Figure 4 Schematic and curative effect for N-PCNSs induced tumor cell destruction via ferritin-mediated specific delivery [39] (color online)…”

Effects of different doses of 2,3‐dimercaptosuccinic acid‐modified Fe2O3nanoparticles on intercalated discs in engineered cardiac tissues

“…14,15 While, beneficial effects of IRONs on electrical transduction and cardiac function were recently revealed by researchers. 16,17 IRONs as MRI contrast agent improved the infarcted myocardium function due to the improvement of possible myocardium remodeling in vivo. 18 Moreover, connexin 43 expression and the assembly of gap junctions of cardiomyocytes in two-dimensional (2D) environment was augmented by IRONs.…”

“…In terms of the effects of IRONs on cardiac tissues and stem cells, a few of studies indicated that IRONs performed rare effects on cardiomyocytes including cardiac mitochondrial respiratory chain complexes activities and the differentiation of embryonic stem cells toward cardiomyocytes . While, beneficial effects of IRONs on electrical transduction and cardiac function were recently revealed by researchers . IRONs as MRI contrast agent improved the infarcted myocardium function due to the improvement of possible myocardium remodeling in vivo .…”