Cardioprotective effect of Nelumbo nucifera on mitochondrial lipid peroxides, enzymes and electrolytes against isoproterenol induced cardiotoxicity in Wistar rats

Subashini, R.; Sumathi, P.

doi:10.1016/s2222-1808(12)60227-8

Cited by 10 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…for two weeks by gastric intubation. After dose and previous preliminary studies; 70 mg/kg body weight isoproterenol for two consecutive days is the most effective inducible dose [20]. So, at the last two days of the experiment, the 2nd and 3rd groups were injected subcutaneously with 70 mg/kg body weight isoproterenol for two consecutive days.…”

Section: Animal Modeling and Experimental Designmentioning

confidence: 99%

See 1 more Smart Citation

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Abdel-Reheim

2016

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: The present study aimed to evaluate the effect of pre-treatment with taurine on rats in which MI had been induced using isoproterenol (ISO).Methods: Rats were randomly allocated into three groups; the 1st group is the normal control (C) one, the 2nd is the isoproterenol cardiotoxic (ISO) one and the 3rd group is the taurine pretreated (T-ISO) one. Results:The activities of the cardiac biomarker enzymes, AST, LDH, CK and CK-MB were elevated in the ISO-treated group. The membrane-bound Na + -K + and Ca 2+ ATPase enzyme activities were decreased in the ISO-treated group. The lipid profile either in sera or cardiac tissues was increased in ISO-treated rats except for HDL-cholesterol and phospholipids. The cholesterol ester synthetase (CES) activity was elevated, while lecithin: Cholesterol acyltransferase (LCAT) and lipoprotein lipase (LPL) activities were decreased in the myocardial infarcted rats. In addition, the high level of the troponins I and T was an indication of cardiac necrosis. Pre-treatment with Taurine, however, ameliorated all of these changes, in addition to its effect in improving the oxidation process, as measured by lipid peroxidation and the antioxidant enzymes, superoxide dismutase and peroxidase enzymes. Conclusion:Taurine showed amelioration effects on the changes in lipid profile, oxidative stress and myocardial infarction biomarkers and therefore, can be protected against cardiotoxicity.

show abstract

Section: Animal Modeling and Experimental Designmentioning

confidence: 99%

“…The 1st group is the normal control (C) one; the 2nd is the isoproterenol cardiotoxic (ISO) one and the 3rd group is the taurine pretreated (T-ISO) one. All groups are decapitated after the two days of isoproterenol injection [20].…”

Section: Animal Modeling and Experimental Designmentioning

confidence: 99%

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Abdel-Reheim

2016

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…[16] ISO-treated cardiotoxic rodent (Group 3) demonstrated expanded levels of LPO in the heart which could be credited to the amassing of ROS in the heart and irreversible harm to the myocardial membrane. [17] Activated LPO is an essential pathogenic occasion in MI, and the levels of lipid peroxide indicate the extent of infection. Pre-treatment with hydroethanolic extract of Z. armatum fruit reduced the levels of TBARS in ISOinduced rats.…”

Section: Resultsmentioning

confidence: 99%

Untitled

Uthamaramasamy¹

2017

IJGP

View full text Add to dashboard Cite

Background: Mitochondrial lipids are essential for the mitochondrial architecture, the activity of respiratory proteins, and the transport of proteins into the mitochondria. Aim: In this study, the preventive role of Zanthoxylum armatum fruit on mitochondrial lipids alteration induced by isoproterenol hydrochloride (ISO) was evaluated in myocardial infarcted (MI) rats. Methods: Oral pre-treatment with hydroethanolic extract of Z. armatum fruit to ISO-induced rats was done for 30 days followed by the isolation of mitochondria from the heart tissue. The lipids such as total cholesterol (TC), phospholipids (PL), triglycerides (TG), and free fatty acids (FFA) in the heart mitochondria and lipid hydroperoxides and thiobarbituric acid reactive substances (TBARS) in the heart tissue were evaluated. Results: ISO-induced MI rats showed a significantly (P < 0.05) increased mitochondrial TC, TG, and FFA with a subsequent decrease in PL. Significantly increased levels of lipid hydroperoxides and TBARS were observed in the heart tissue of ISO-treated rats. Oral pre-treatment with hydroethanolic extract of Z. armatum fruit to ISO-induced rats significantly (P < 0.05) reverted these alterations near to normal status. Conclusion: Pretreatment with Z. armatum fruit favorably restored the biochemical alterations demonstrating that Z. armatum fruit has a significant protective effect on cardiac mitochondrial function against ISO-induced MI in rats.

show abstract

“…However, Alagawany et al [ 26 ] reported that there was no change in serum biochemical markers (TP, TC, TG, ALT, and AST) between broilers fed a garlic-enriched diet and those fed a control diet. Hypertriglyceridemia may be caused by a decrease in lipoprotein lipase activity combined with an increase in hormone-sensitive lipase activity, resulting in decreased TG uptake from the circulation [ 44 ]. Codoñer-Franch et al [ 45 ] reported that anti-oxidant enzymes are destroyed by excess synthesis of oxidized low-density lipoproteins (ox-LDL), which inhibits SOD expression, and could also be responsible for decreased SOD activity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Feeding Pomegranate (Punica granatum) Peel and Garlic (Allium sativum) on Antioxidant Status and Reproductive Efficiency of Female Rabbits

Hagag

Younis

Al-Eisa

et al. 2023

Veterinary Sciences

View full text Add to dashboard Cite

Egypt’s animal protein shortfall cannot be overcome by expanding the production of large animals alone, but rather by increasing the production of highly reproducing animals in the livestock unit. The goal of this study was to examine how adding pomegranate peel (PP), garlic powder (GP), or a mixture of the two to the diet of does affect their weight, the number of offspring, reproductive performance, hematological indices, and several antioxidants indicators as well as the liver and kidney functions. A total of 20 adult and mature female mixed rabbits at age 4.5–5 months and averaging 3.05 ± 0.63 kg body weight, were allocated into four experimental groups (n = 5). The first group was provided with the basal diet and was considered as control animals, while the second, third, and fourth groups were fed the basal diet supplemented with PP 3.0%, GP 3.0%, and a mixture of PP 1.5% + GP 1.5%, respectively. After 2 weeks of feeding the experimental diets, natural mating with untreated bucks was carried out. The kits were weighed immediately after parturition, and then every week. The study found that rabbits fed with 3% PP led to a 28.5% increase in the number of kits at birth compared to the control group. As an effect of supplementing PP 3%, GP 3%, and PP 1.5% + GP 1.5%, the birth weight increased by 9.2%, 7.2%, and 10.6%, respectively, as compared to the control. Hemoglobin increased significantly in all treatment groups as compared to the control at the age of kit weaning. Lymph cells increased significantly in the rabbits that were fed with GP (3%) than in other groups and even the control. The results showed that creatinine levels were significantly decreased in the PP (3%) and GP (3%) than in control rabbits. The level of triglycerides significantly declines in groups treated with PP (3%) than in other treatment groups and the control. The addition of PP 3% or GP 3% increased the progesterone hormone. The addition of PP 1.5%+GP 1.5% improved the immunoglobulin IgG. The results of superoxide dismutase, catalase, glutathione, and total antioxidant capacity showed a significant decline in groups treated with GP (3%) than other treated groups. In conclusion, pomegranate is a promising substance to include in a rabbit’s diet, followed by garlic to boost reproductive efficiency.

show abstract

Cardioprotective effect of Nelumbo nucifera on mitochondrial lipid peroxides, enzymes and electrolytes against isoproterenol induced cardiotoxicity in Wistar rats

Cited by 10 publications

References 6 publications

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Cardioprotective Efficacy of Taurine on Lipid-Metabolism of Isoproterenol-Induced Myocardial Infarction

Untitled

Effect of Feeding Pomegranate (Punica granatum) Peel and Garlic (Allium sativum) on Antioxidant Status and Reproductive Efficiency of Female Rabbits

Contact Info

Product

Resources

About