Cardioprotective effect of tincture of <i>Crataegus</i> on isoproterenol-induced myocardial infarction in rats

Jayalakshmi, R.; Devaraj, S. Niranjali

doi:10.1211/0022357023745

Cited by 44 publications

(34 citation statements)

References 28 publications

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“…The increased levels of TBA reactive substances indicate the excessive formation of free radicals and activation of lipid peroxidation system resulting in irreversible damage to the heart in animals subjected to ISO stress. The significant increase observed in the levels of lipid peroxides in serum and heart of ISO infracted rats compared to control, was in accordance with the observation of previous reports [14]. Table 2 shows the levels of enzymatic antioxidants SOD, Catalase and Glutathione peroxidase (GPx).…”

Section: Lpo-lipid Peroxidationsupporting

confidence: 91%

Antioxidant Effect of Polyherbal Formulation in Isoprenaline Hydrochloride Induced Myocardial Infarction in Rats

Kavitha¹,

Sowmia²

2017

Int J Pharm Pharm Sci

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Objective: Myocardial infarction (MI) continues to be a major public health problem in the world. The prepared polyherbal formulation (PHF) exhibit cardioprotective effects by several mechanisms. The objective of the research was to evaluate the antioxidant effect of a polyherbal formulation in isoprenaline hydrochloride (ISO) induced myocardial infarction in rats.Methods: Oxidative stress and myocardial infarction was induced by administration of isoprenaline hydrochloride (25 mg/kg) for 2 d. The degree of protection was determined by measuring the levels of lipid peroxidation (LPO), enzymatic antioxidants (superoxide dismutase-SOD, Catalase, Glutathione peroxidase) and non-enzymatic antioxidants (Vitamin C, E and reduced glutathione-GSH).Results: Two different doses (250 mg and 500 mg/kg body wt) of the formulation was used to prove the cardioprotective effect. Pretreatment with polyherbal formulation significantly (P<0.05) lowered LPO and elevated the enzymatic and non-enzymatic antioxidants in heart homogenate. Conclusion:The polyherbal formulation exhibited cardioprotective activity, which could be attributed to its antioxidant activity.

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Section: Lpo-lipid Peroxidationsupporting

confidence: 91%

Antioxidant Effect of Polyherbal Formulation in Isoprenaline Hydrochloride Induced Myocardial Infarction in Rats

Kavitha¹,

Sowmia²

2017

Int J Pharm Pharm Sci

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“…Another species of Crataegus genus, oxyacantha was reported to have cardioprotective effect and antioxidant activity by inhibiting lipid peroxidation (TBARS) and augmenting enzymatic and non-enzymatic antioxidants in experimentally induced myocardial infarction in rats (Jayalakshmi & Niranjali Devaraj, 2004). In addition, extracts of Crataegus aronia (400 mg/kg) decreased total cholesterol and LDL in rats (Al-Hallaq et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

et al. 2017

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SUMMARY:Complications of fat accumulation in liver, hepatic steatosis such as liver cirrhosis and liver failure are among the common public health problems. We sought to investigate the damage to the hepatocyte ultrastructure induced by high fat diets (HFD) and compared the therapeutic effects at the cellular level of two antioxidant and lipid lowering agents; Crataegus aronia extracts and simvastatin on hepatic steatosis. Rats were either fed with HFD (model group) or low fat diets (LFD) (control group) for 15 weeks before being sacrificed and therapeutic groups started the treatment with these agents after week 11 until the sacrifice day. Harvested liver tissues were examined using transmission electron microscopy (TEM) and liver homogenates were assayed for markers of antioxidative stress that are known to be modulated in liver injury. TEM examinations of the model group showed a profound damage to the hepatocytes compared to the control group as demonstrated by steatosis, damaged mitochondria and vaculated cytoplasm, disrupted rough and smooth endoplasmic reticulum and nuclear membrane, dilated intercellular space between hepatocytes, and alterations in lysosomes. In addition, HFD ameliorated the anti-oxidant glutathione (GSH) and augmented the oxidative stress TBARS biomarkers. Both Crataegus aronia and simvastatin significantly reduced lipids and TBARS, and treated damage to hepatic cells, but hepatocyte structures were differentially responded to these agents. However, only Crataegus aronia induced GSH (p=0.001). We conclude that HFD-induced hepatic steatosis caused a substantial damage to the hepatocyte's ultrastructures, and Crataegus aronia and simvastatin treatments differentially reversed hepatic injuries.

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“…Therapeutic intervention showing antioxidant or free radical scavenging activity should exert beneficial effects against oxidative stress associated with various cardiovascular diseases (CVDs) [27]. Possible mechanisms of tincture of Crataegus (TCR) include preventing the increase in lipid peroxidation and activity of marker enzymes, preventing the isoproterenol-induced decrease in antioxidant enzymes in the heart, and increasing the rate of ADP-stimulated oxygen uptake and respiratory coupling ratio in isoproterenol-induced rats [28]. As we know, CVDs are associated with the structural and functional disturbances in heart mitochondria.…”

Section: Cardiovascular Effectmentioning

confidence: 99%

“…Besides, it showed evident effect against reperfusion arrhythmias by reducing the average prevalence of malignant arrhythmias (VF + Flutter) and the average prevalence of ventricular tachycardia (VT) [68]. Moreover, it prevented the isoproterenol-induced decrease in antioxidant enzyme activity [69]. …”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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Cardioprotective effect of tincture of Crataegus on isoproterenol-induced myocardial infarction in rats

Cited by 44 publications

References 28 publications

Antioxidant Effect of Polyherbal Formulation in Isoprenaline Hydrochloride Induced Myocardial Infarction in Rats

Antioxidant Effect of Polyherbal Formulation in Isoprenaline Hydrochloride Induced Myocardial Infarction in Rats

Differential Therapeutic Effects of Crataegus aronia and Simvastatin on the Hepatocyte Ultrastructure in Hepatic Steatosis

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

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