Cardioprotective Effects of Dietary Phytochemicals on Oxidative Stress in Heart Failure by a Sex-Gender-Oriented Point of View

Abstract

Dietary phytochemicals are considered an innovative strategy that helps to reduce cardiovascular risk factors. Some phytochemicals have been shown to play a beneficial role in lipid metabolism, to improve endothelial function and to modify oxidative stress pathways in experimental and clinical models of cardiovascular impairment. Importantly, investigation on phytochemical effect on cardiac remodeling appears to be promising. Nowadays, drug therapy and implantation of devices have demonstrated to ameliorate survival. Of interest, sex-gender seems to influence the response to HF canonical therapies. In fact, starting by the evidence of the feminization of world population and the scarce efficacy and safety of the traditional drugs in women, the search of alternative therapeutic tools has become mandatory. The aim of this review is to summarize the possible role of dietary phytochemicals in HF therapy and the evidence of a different sex-gender-oriented response.

Umbelliprenin relieves paclitaxel-induced neuropathy

“…including cardiovascular and cerebrovascular conditions, inflammation and chemotherapy-induced neuropath. [47,48,50,51] Shim et al [48] confirmed the connection between oxidative stress and neuropathy induced by PTX. In the case of PTX chemotherapy, central (spinal) oxidative stress leads to hyperalgesia and allodynia.…”

Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats

“…Improved hemodynamics function by GA/ATV pretreatment clearly indicates its favorable effect on heart in course of the ischemic insult caused by ISO. Several reports illustrates the beneficial effect of phytochemicals on cardiac tissue remodeling (Romão et al, 2019;Komici et al, 2020). Indeed, a large number of experimental models report that FIGURE 4 | Effect of GA on ISO-induced fibrotic gene expression profile in heart tissue.…”

The Effects of Resveratrol on Telomeres and Post Myocardial Infarction Remodeling

“…They also reviewed the pharmacokinetics of commercial resveratrol formulations [ 3 ]. According to Komici et al phytochemicals like resveratrol are an innovative strategy to decrease cardiovascular risk factors, clinical evidence supports the cardioprotective effects of resveratrol [ 37 ]. They noted that further research should be conducted on the effects of resveratrol on cardiac remodeling [ 37 ].…”

“…According to Komici et al phytochemicals like resveratrol are an innovative strategy to decrease cardiovascular risk factors, clinical evidence supports the cardioprotective effects of resveratrol [ 37 ]. They noted that further research should be conducted on the effects of resveratrol on cardiac remodeling [ 37 ]. They also studied the effects of resveratrol in HF therapy and the difference in sex-gender-oriented responses to treatment [ 37 ].…”

“…They noted that further research should be conducted on the effects of resveratrol on cardiac remodeling [ 37 ]. They also studied the effects of resveratrol in HF therapy and the difference in sex-gender-oriented responses to treatment [ 37 ]. A review by Lapuente et al concluded that bioactive substances in fruits and vegetables like resveratrol have a protective effect on the development of atherosclerosis [ 20 ].…”