Cardioprotective effects of Schisantherin A against isoproterenol-induced acute myocardial infarction through amelioration of oxidative stress and inflammation via modulation of PI3K-AKT/Nrf2/ARE and TLR4/MAPK/NF-κB pathways in rats

Mi, Xiaolong; Zhang, Zhijun; Cheng, Jinfang; Xu, Zheng; Zhu, Kaiyi; Ren, Yong

doi:10.1186/s12906-023-04081-x

Cited by 8 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In vivo, MDA is the final product of oxidation reaction of free radicals. It contains relatively high cytotoxicity, which is easy to cause the destruction and dysfunction of macromolecular structures such as proteins in cells, resulting in oxidative damage of the body [ 28 , 29 ]. An antioxidant metalloenzyme existing in SOD organism, it can catalyze superoxide anion radical disproportionation, and plays a crucial role in the balance between oxidation and antioxidant in the body.…”

Section: Discussionmentioning

confidence: 99%

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium

Du,

Lu,

Xiao

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Purpose This study aims to investigate the protective mechanism of dihydromyricetin PLGA nanoparticles (DMY-PLGA NPs) against myocardial ischemia-reperfusion injury (MIRI) in vitro and the improvement of oral bioavailability in vivo. Methods DMY-PLGA NPs was prepared and characterized by emulsifying solvent volatilization, and the oxidative stress model of rat H9c2 cardiomyocyte induced by H2O2 was established. After administration, cell survival rate, lactate dehydrogenase (LDH), malondialdehyde (MDA) and superoxide dismutase (SOD) were detected, and the expressions of PGC1α and PPARα were detected by western blot (WB). At the same time, the pharmacokinetics in rats were studied to explore the improvement of bioavailability. Results DMY-PLGA NPs can significantly increase cell survival rate, decrease LDH and MDA content, increase SOD content and PGC1α、PPARα protein expression. Compared with DMY, the peak time of DMY-PLGA NPs was extended (P<0.1), and the bioavailability was increased by 2.04 times. Conclusion DMY-PLGA NPs has a significant protective effect on H9c2 cardiomyocytes, which promotes the absorption of DMY and effectively improves bioavailability.

show abstract

Section: Discussionmentioning

confidence: 99%

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium

Du,

Lu,

Xiao

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Previous studies have highlighted the importance of inflammation in AMI in both human and animals. 33 , 34 , 35 , 36 Hypoalbuminaemia is a known marker of inflammation. 37 In the present study, patients with LVA exhibited lower level of ALB than those without LVA, suggesting that inflammation may play a crucial role in this association.…”

Section: Discussionmentioning

confidence: 99%

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Zhang,

Yang,

et al. 2024

ESC Heart Failure

View full text Add to dashboard Cite

AimsLeft ventricular aneurysm (LVA) is an important complication of acute myocardial infarction. The aim of this study was to investigate the possible predictive value of blood urea nitrogen‐to‐albumin ratio (BAR) for the LVA formation in acute ST‐segment elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention (PCI).Methods and resultsA total of 1123 consecutive patients with STEMI were prospectively enrolled. The clinical and laboratory data were compared between LVA group and non‐LVA group. Multivariable logistic regression analysis was performed to assess the independent risk factors of LVA formation. Predictive power of BAR and composite variable for LVA formation were assessed using receiver operating characteristic curve. LVA was detected in 162 patients (14.4%). The BAR was significantly higher in patients with LVA [0.16 (0.13–0.19) vs. 0.13 (0.10–0.17), P < 0.001]. Multivariable logistic regression analysis revealed that left ventricular ejection fraction (LVEF) [odds ratio (OR) = 0.865, P < 0.001], culprit vessel–left anterior descending artery (LAD) (OR = 4.705, P < 0.001), and BAR (OR = 2.208, P = 0.018) were all independent predictors for LVA formation. The predictive value of BAR remained significant even after cross‐validation by splitting population into training set (OR = 1.957, P = 0.034) and validation set (OR = 1.982, P = 0.039). The maximal length and width of LVA were significantly increased in patients with BAR ≥ 0.15 when compared with BAR < 0.15 (3.37 ± 1.09 vs. 2.92 ± 0.93, P = 0.01, for maximal length, and 2.20 ± 0.55 vs. 1.85 ± 0.63, P = 0.001, for maximal width). The discriminant power of BAR for LVA is 0.723, which is superior to both blood urea nitrogen (C statistic = 0.586, P < 0.001) and albumin (C statistic = 0.64, P < 0.001). The combination of BAR, LVEF, and culprit vessel–LAD could significantly increase the predictive ability (C statistic = 0.874, P < 0.001, for vs. BAR). Subgroup analysis of age, sex, hypertension, diabetes, smoking, LVEF, serum albumin, multiple‐vessel disease, and Gensini score had no effect on the association between BAR and risk of LVA formation (P < 0.05 for all subgroups).ConclusionsA higher BAR was an independent predictor for LVA formation in STEMI patients with primary PCI.

show abstract

“…Schisandra chinensis contains a significant amount of pharmacologically active components, with the majority being phenolic substances such as flavonoids, lignans, and anthocyanins. Lignan is the main pharmacologically active ingredient in Schisandra chinensis; it has shown a good curative effect on many diseases [3][4][5][6][7]. Therefore, this experiment conducted an in-depth study on lignans.…”

Section: Analysis Of Lignans In Fruit Of Schisandra Chinensis At Diff...mentioning

confidence: 99%

“…Moreover, schisandrin A has been reported to mitigate asthma symptoms through its anti-inflammatory action [5]. Schisantherin A markedly curtails oxidative stress and inflammation induced by isoproterenol, offering prophylactic protection against myocardial infarction-induced cardiac injury [6]. Schisandrin B, within the body, suppresses cellular proliferation and prompts apoptosis by influencing signaling cascades, suggesting a viable therapeutic strategy for colon cancer tumor suppression [7].…”

Section: Introductionmentioning

confidence: 99%

Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed

Sun,

Yan,

et al. 2024

Molecules

View full text Add to dashboard Cite

Schisandra chinensis, as a traditional Chinese herbal medicine, has clear pharmacological effects such as treating asthma, protecting nerves and blood vessels, and having anti-inflammatory properties. Although the Schisandra chinensis fruit contain multiple active components, the lignans have been widely studied as the primary pharmacologically active compound. The volatile chemical components of Schisandra chinensis include a large amount of terpenes, which have been proven to have broad pharmacological activities. However, when to harvest to ensure the highest accumulation of pharmacologically active components in Schisandra chinensis fruits is a critical issue. The Schisandra chinensis fruit trees in the resource nursery were all planted in 2019 and began bearing fruit in 2021. Their nutritional status and tree vigor remain consistently good. The content of lignans and organic acids in the fruits of Schisandra chinensis over seven different harvest periods was tested, and the results of high-performance liquid chromatography (HPLC) indicated that the lignan content was higher, at 35 mg/g, in late July, and the organic acid content was higher, at 72.34 mg/g, in early September. If lignans and organic acids are to be selected as raw materials for pharmacological development, the harvest can be carried out at this stage. Using HS-GC-IMS technology, a total of 67 volatile flavor substances were detected, and the fingerprint of the volatile flavor substances in the different picking periods was established. It was shown by the results that the content of volatile flavor substances was the highest in early August, and 16 flavor substances were selected by odor activity value (OAV). The variable importance in projection (VIP) values of 16 substances were further screened, and terpinolene was identified as the key volatile flavor substance that caused the aroma characteristics of Schisandra chinensis fruit at different harvesting periods. If the aroma component content of Schisandra chinensis fruit is planned to be used as raw material for development and utilization, then early August, when the aroma component content is higher, should be chosen as the time for harvest. This study provides a theoretical basis for the suitable harvesting time of Schisandra chinensis for different uses, and promotes the high-quality development of the Schisandra chinensis industry.

show abstract

Cardioprotective effects of Schisantherin A against isoproterenol-induced acute myocardial infarction through amelioration of oxidative stress and inflammation via modulation of PI3K-AKT/Nrf2/ARE and TLR4/MAPK/NF-κB pathways in rats

Cited by 8 publications

References 54 publications

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium

Protective effect and pharmacokinetics of dihydromyricetin nanoparticles on oxidative damage of myocardium

Urea nitrogen‐to‐albumin ratio predicts ventricular aneurysm formation in ST‐segment elevation myocardial infarction

Based on HPLC and HS-GC-IMS Techniques, the Changes in the Internal Chemical Components of Schisandra chinensis (Turcz.) Baill. Fruit at Different Harvesting Periods Were Analyzed

Contact Info

Product

Resources

About