Cardioprotective effects of selenium on chromium (VI)-induced toxicity in female rats

Soudani, Nejla; Troudi, Afef; Bouaziz, Hanen; Amara, Ibtissem Ben; Boudawara, Tahia; Zeghal, Najiba

doi:10.1016/j.ecoenv.2010.06.009

Cited by 46 publications

(43 citation statements)

References 50 publications

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“…The protective effects of sodium selenite and/or vitamin E could be related to the formation of a selenium-mercury complex and impaired absorption of mercury in the presence of vitamin E in the gastrointestinal tract and also their antioxidant effects. Toxic metals can lead to histopathological changes in the myocardium (Soudani et al 2011;Ansaria et al 2013). In this study, mercuric chloride treatment caused histopathological changes such as inflammatory cell infiltration, edema, vacuolar degeneration, disorganization of myocardial fibers and necrosis in heart tissue.…”

Section: Discussionmentioning

confidence: 90%

“…The light microscopic findings support the result of the biochemical assays. Soudani et al (2011) reported that chromium (VI) treatment caused histopathological changes such as myonecrosis, vacuolization, hemorrhage and fibrosis in the cardiac tissues of rats. In this study, the necrosis observed in the heart tissue of the mercuric chloride-treated rats did not exist in the rats that received sodium selenite and/or vitamin E co-administration.…”

Section: Discussionmentioning

confidence: 99%

“…Some heavy metals can cause physiological, biochemical and histological alterations (Al-Attar 2011). Several risk factors, including the industrial pollution of the environment with metal compounds are associated with cardiovascular diseases (Soudani et al 2011). Mercury is one of the most toxic metals.…”

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats

Karaboduk

Uzunhisarcıklı

Kalender

2015

Braz. arch. biol. technol.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats

Karaboduk

Uzunhisarcıklı

Kalender

2015

Braz. arch. biol. technol.

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“…In an epidemiologic study of boilermakers, Magari et al [54] suggested an association between exposure to chromium and significant alterations in cardiac autonomic function. Soudani et al [55] showed that K 2 Cr 2 O 7 treatment induce oxidative stress and abnormal ultrastructural changes such as myonecrosis, vacuolization, hemorrhage, and fibrosis in the cardiac tissue of rats that received 700 ppm in drinking water during 21 days. Tsapakos et al [56] observed low levels of strand break in rat lung after intraperitoneal injection of sodium dichromate (20 mg/kg b.w.)…”

Section: A B C Dmentioning

confidence: 99%

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

García-Niño

Zatarain-Barrón

Hernández-Pando

et al. 2015

Biol Trace Elem Res

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Hexavalent chromium [Cr(VI)] compounds are extremely toxic and carcinogenic. Despite the vast quantity of reports about Cr(VI) toxicity, the information regarding its effects when it is intraperitoneally (i.p.) administered is still limited. In contrast, it has been shown that curcumin prevents hepatotoxicity induced by a single intraperitoneal injection of 15 mg/kg body weight (b.w.) of potassium dichromate (K2Cr2O7). This study aims to evaluate oxidative stress markers, the activity of antioxidant enzymes, and the potential histological injury in brain, heart, lung, kidney, spleen, pancreas, stomach, and intestine from rats treated with a hepatotoxic dose of K2Cr2O7 (15 mg/kg b.w.), and the effect of curcumin pretreatment. Rats were divided into four groups: control, curcumin, K2Cr2O7, and curcumin+K2Cr2O7. At the end of the treatment, plasma and ascites fluid were collected and target organs were dissected out for biochemical and histological analysis. K2Cr2O7 induced hepatotoxicity but failed to induce in all the other studied organs either oxidative or histological injury, since levels of malondialdehyde (MDA), glutathione (GSH), and the activity of superoxide dismutase (SOD), catalase (CAT), and related GSH enzymes were unchanged. As expected, curcumin was safe. Lack of K2Cr2O7-induced toxicity in those target organs could be due to the following: (1) route of administration, (2) absorption through the portal circulation, (3) lower dose than needed, (4) short time of exposure, or (5) repeated doses are required to produce damage. Thus, the intraperitoneal injection of 15 mg/kg of K2Cr2O7, that is able to induce hepatotoxicity, was unable to induce histological and oxidative damage in other target organs.

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“…Among antioxidant micronutrients, selenium (Se) is an essential dietary trace element, which plays an important role in a number of biological processes in humans and other species (13). Deficiency of this element induces some pathological conditions, such as cancer, coronary heart disease, and liver necrosis (14)(15)(16). Researchers have shown selenium and zinc efficacy on immune system and increase response to influenza and HBV vaccine (17).…”

Section: Introductionmentioning

confidence: 99%

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

Ahmadvand

Khosrowbeygi

2015

Zahedan J Res Med Sci

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Background: Diabetes-related dysfunctions are the major causes of mortality and morbidity for diabetic patients. Objectives: Selenium is a potent antioxidant. In the present study, we examined antioxidative activities of sodium selenite and possible protective effect of it on serum, liver and kidney lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats. Materials and Methods: In this experimental study 40 Sprage Dawley male rats were divided into 4 groups randomly; group I as control, group II as sham treated with sodium selenite (1 mg/kg i.p. daily), group III as diabetic untreated, and group IV as diabetic treated with sodium selenite (1 mg/kg i.p. daily) after induce diabetes, respectively. Diabetes was induced in the 3rd and 4th groups by alloxan injection (s.c.). After 8 weeks, animals were anaesthetized, liver and kidney were then removed immediately and used fresh or kept frozen until analysis. Blood samples were also collected before killing of the rats to measure the lipid peroxidation and glutathione level. Results: Liver and kidney content of lipid peroxidation decreased in diabetic treated group compared with untreated group. Kidney content of glutathione significantly increased in diabetic treated group compared with untreated group. Serum level of glutathione and liver content of it slightly increased in diabetic treated group compared with untreated group. Conclusions: This study showed that sodium selenite might be a potent antioxidant and exert beneficial effects on the lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats.

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Cardioprotective effects of selenium on chromium (VI)-induced toxicity in female rats

Cited by 46 publications

References 50 publications

Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats

Protective Effects of Sodium Selenite and Vitamin E on Mercuric Chloride-Induced Cardiotoxicity in Male Rats

Oxidative Stress Markers and Histological Analysis in Diverse Organs from Rats Treated with a Hepatotoxic Dose of Cr(VI): Effect of Curcumin

Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

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