Effect of Sodium Selenite on Lipid Peroxidation and Glutathione in Alloxan Induced Diabetic Rats

Abstract

Background: Diabetes-related dysfunctions are the major causes of mortality and morbidity for diabetic patients. Objectives: Selenium is a potent antioxidant. In the present study, we examined antioxidative activities of sodium selenite and possible protective effect of it on serum, liver and kidney lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats. Materials and Methods: In this experimental study 40 Sprage Dawley male rats were divided into 4 groups randomly; group I as control, group II as sham treated with sodium selenite (1 mg/kg i.p. daily), group III as diabetic untreated, and group IV as diabetic treated with sodium selenite (1 mg/kg i.p. daily) after induce diabetes, respectively. Diabetes was induced in the 3rd and 4th groups by alloxan injection (s.c.). After 8 weeks, animals were anaesthetized, liver and kidney were then removed immediately and used fresh or kept frozen until analysis. Blood samples were also collected before killing of the rats to measure the lipid peroxidation and glutathione level. Results: Liver and kidney content of lipid peroxidation decreased in diabetic treated group compared with untreated group. Kidney content of glutathione significantly increased in diabetic treated group compared with untreated group. Serum level of glutathione and liver content of it slightly increased in diabetic treated group compared with untreated group. Conclusions: This study showed that sodium selenite might be a potent antioxidant and exert beneficial effects on the lipid peroxidation and glutathione in alloxan-induced type 1 diabetic rats.

Chitosan‐stabilized selenium nanoparticles attenuate acrylamide‐induced brain injury in rats

“…These results indicated that the treatment with sodium selenite led to attenuate the effect of ACR on rats. In harmony with this finding, Ahmadvand and Khosrowbeygi (2015) had indicated that the decrease in MDA values is an indicator of the ability of the sodium selenite solution to reduce the rate of fat oxidation. However, in G4 significant differences still could be noticed in all tested parameters compared to G1.…”

Role of growth factors and biomaterials in wound healing

“…Stem cells are cells that can retain prolonged self-renewal ability and can differentiate into numerous tissue types [9]. There are different sources of stem cells such as embryonic stem cells, induced pluripotent stem cells, bone marrow stem cells (BMSCs) and adipose-derived stem cells (ASCs) [10].…”

The Attenuation of Mercuric Chloride Toxicity by Flavonoids in Male Albino Rats Is Independent on the Number of Hydroxyl Groups on B-Rings

“…Humans are exposed to this metal from numerous sources; contaminated air, water, soil, and food [1] . Selenium and flavonoids have been shown to alleviate heavy metal toxicity [9,14] . Therefore, the present study aimed to evaluate the possible mitigating effect of selenite, and some flavonoids (morin, naringin and hesperetin) against acute HgCl 2 toxicity.…”

“…A total number of 70 adult male albino rats were randomly divided into 10 groups (n=7/group) as follows: a control group (group 1), groups 2 and 6 were orally administered with 5 mg/kg body weight of either sodium selenite or HgCl 2 , respectively [9,10] . Groups 3, 4, and 5 were orally treated with 50 mg/kg body weight of morin, naringin, or hesperetin, respectively [11][12][13] .…”

“…Some other organic forms are readily disintegrated and excreted [8] . Therefore, sodium selenite, although toxic in high doses, is considered the most effective selenium source [9] . The present study aimed to evaluate the effect of some flavonoids (morin, naringin and hesperetin) and sodium selenite on the hepato-, nephron-, and hemato-toxicity induced by mercuric chloride (HgCl 2 ) in adult male rats.…”