Cardioprotective Role of Melatonin in Acute Myocardial Infarction

Fu, Zhenhong; Jiao, Yang; Wang, Jihang; Zhang, Ying; Shen, Mingzhi; Reíter, Russel J.; Xi, Qing; Chen, Yundai

doi:10.3389/fphys.2020.00366

Cited by 62 publications

(51 citation statements)

References 212 publications

(192 reference statements)

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“…Ischaemia/reperfusion injury and myocardial infarction are manifested by aggressive inflammatory reactions that can cause severe consequences, even mortality (155). In a murine model, administration of melatonin prior to ischaemic insult attenuates TLR4 pathways by the activation of SAFE mechanism (156).…”

Section: Melatonin and Myocardial Infarctionmentioning

confidence: 99%

“…In a murine model, administration of melatonin prior to ischaemic insult attenuates TLR4 pathways by the activation of SAFE mechanism (156). Besides, melatonin-mediated regulation of several intracellular signalling cascades such as MAPK and JAK-STAT pathways, as well as SIRT1/FOXO1, Notch/Hes/PI3K/Akt/SIRT3, AMP-dependent protein kinase (AMPK)/peroxisome proliferator-activated receptor γ co-activator 1α (PGC1α)/SIRT3 and AMPK/Protein kinase G-1α (PKG1α)/NF-E2-related factor2 (Nrf2) axes have been implicated in defending against inflammatory responses during myocardial infarction (155,157). Due to the lipophilic property, melatonin easily reaches cytosol and activates SIRT1, SIRT3 and Nrf2 to exert its anti-inflammatory activity (155).…”

Section: Melatonin and Myocardial Infarctionmentioning

confidence: 99%

“…Besides, melatonin-mediated regulation of several intracellular signalling cascades such as MAPK and JAK-STAT pathways, as well as SIRT1/FOXO1, Notch/Hes/PI3K/Akt/SIRT3, AMP-dependent protein kinase (AMPK)/peroxisome proliferator-activated receptor γ co-activator 1α (PGC1α)/SIRT3 and AMPK/Protein kinase G-1α (PKG1α)/NF-E2-related factor2 (Nrf2) axes have been implicated in defending against inflammatory responses during myocardial infarction (155,157). Due to the lipophilic property, melatonin easily reaches cytosol and activates SIRT1, SIRT3 and Nrf2 to exert its anti-inflammatory activity (155). When melatonin is used as adjunctive therapy with primary percutaneous coronary intervention (pPCI) in acute myocardial infarction patients with ST-segment elevation, it significantly improves the efficacy of pPCI and leads to the reduction of infarct size (158,159).…”

Section: Melatonin and Myocardial Infarctionmentioning

confidence: 99%

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Multiple strategies of melatonin protecting against cardiovascular injury related to inflammation: A comprehensive overview

Sarkar¹,

Chattopadhyay²,

Bandyopadhyay³

2021

Melatonin Res.

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The onset and progression of baneful chronic diseases are often accompanied by a torrent of uncontrolled inflammatory reactions. Although inflammation is a natural response to detect, eliminate, and counterpoise the harmful insults to physiological integrity, a persistent inflammation causes tissue damage or more serious disorders, for example, the atherosclerosis and myocardial infarction. Inflammation often occurs in the cardiovascular system, but are also caused by other disorders including metabolic syndrome, autoimmune diseases, AIDS, and cancer that can affect the cardiac health. To effectively treat heart diseases a potent remedy is necessary which not only suppresses the inflammation but also prevents inflammation-associated cardio-pathogenesis. The ubiquitous antioxidant molecule melatonin has both anti-inflammatory and cardioprotective activities. Melatonin executes its anti-inflammatory activity by its antioxidant function or by targeting multiple intracellular signalling cascades such as modulating cytokine profile, blocking inflammasome activation and apoptosis. Lipid dysregulation and endothelial dysfunction that play a crucial role in the pathogenesis of atherosclerosis, insulin resistance, and diabetes are prevented by melatonin. Attenuation of mitochondrial and ER stress by melatonin is also pertinent to its cardioprotective action. Additionally, melatonin by its immuno-stimulatory activity can suppress inflammaging and immuno-senescence in HIV patients and thereby averts chronic inflammation-induced cardiovascular abnormality in these subjects. Modulation of cytokine profile and decrease in MMP-9 secretion by melatonin is beneficial in autoimmune conditions. In addition to its anti-tumour potency, melatonin can reduce chemotherapy-induced cardio-toxicity in cancer patients. This review, therefore, provides a concise summary of the currently available information appertaining to the roles of melatonin in mitigation of chronic inflammation and its effect on cardiovascular integrity.

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Section: Melatonin and Myocardial Infarctionmentioning

confidence: 99%

Section: Melatonin and Myocardial Infarctionmentioning

confidence: 99%

Section: Melatonin and Myocardial Infarctionmentioning

confidence: 99%

See 1 more Smart Citation

Multiple strategies of melatonin protecting against cardiovascular injury related to inflammation: A comprehensive overview

Sarkar¹,

Chattopadhyay²,

Bandyopadhyay³

2021

Melatonin Res.

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“…Melatonin, an endogenously-produced molecule with protective effects on cardiomyocytes [6,7], could be a significant player in therapeutic approaches to damaged heart in COVID-19. Melatonin is known primarily for its circadian synthesis and release by the vertebrate pineal gland, but it is also widely distributed in non-vertebrates, which lack a pineal gland, and in plants [8].…”

Section: Protective Effects Of Melatoninmentioning

confidence: 99%

“…In rat models of heart failure induced by isoproterenol, melatonin decreased the level of oxidative stress, improved left ventricular function, reduced collagen content and concentration and improved survival [20]. Furthermore, melatonin enhances bioavailability of nitric oxide and improves endothelial function at various levels, alleviates intraplaque inflammation and protects ischemic cardiomyocytes via receptor and non-receptor pathways potentially mitigating the risk of acute coronary syndrome [6], and reperfusion damage [7].…”

Section: Melatonin´s Interactions With Cardiovascular Pathologiesmentioning

confidence: 99%

Melatonin as a putative protection against myocardial injury in COVID-19 infection

Šimko

Hrenak

Reíter

2020

Expert Review of Clinical Pharmacology

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The coronavirus disease 2019 (COVID-19) reached pandemic proportions in March 2020 with unexpectedly rapid spread and serious health and social impacts. In the middle of August, the population of infected patients worldwide has risen to more than 20 million with 750 000 deaths. Number of severely affected patients in some countries overwhelms the capacities of hospitals and places insurmountable demands on healthcare systems. Acute respiratory distress syndrome (ARDS), as the most frequent serious complication, has been under thorough investigation since the beginning of the pandemic. Yet, cardiovascular consequences, the other commonly occurring complication contributing to a poor prognosis, has received much less attention and it remains still poorly defined [1]. * FS and JH contributed equally.

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Supramolecular self‐assembled nanoparticles for targeted therapy of myocardial infarction by enhancing cardiomyocyte mitophagy

Jiao,

Wang,

Weng

et al. 2024

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Myocardial infarction accompanied by diabetes mellitus is accepted as the most serious type of coronary heart disease, and among the current treatment strategies, the precise delivery of protective drugs for inhibiting cardiomyocyte apoptosis is still a challenge. In this study, we developed a biodegradable nanoparticles‐based delivery system with excellent macrophage escape, cardiac targeting, and drug release properties to achieve targeted therapy of myocardial infarction. Specifically, a copolymer of p(DMA–MPC–CD) combining self‐adhesion, hydration lubrication, and targeting peptide binding site was successfully prepared by free radical copolymerization, and it was self‐assembled on the surface of melatonin‐loaded dendritic mesoporous silica nanoparticles (bMSNs) following the integration of adamantane‐modified cardiac homing peptide (CHP) based on supramolecular host–guest interaction. Importantly, a hydration layer formed around the zwitterionic phosphorylcholine groups of the multifunctional nanoparticles, which was confirmed by the enhancement in hydration lubrication and reduction in coefficient of friction, prevented the nanoparticles from phagocytosis by the macrophages. The in vivo bioluminescence imaging test indicated that the nanoparticles were endowed with satisfied cardiac targeting capability, and the in vivo mice study demonstrated that the intravenous injection of drug‐loaded nanoparticles (namely bMSNs–Mel@PDMC–CHP) effectively reduced cardiomyocyte apoptosis, alleviated myocardial interstitial fibrosis, and enhanced cardiac function.

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Cardioprotective Role of Melatonin in Acute Myocardial Infarction

Cited by 62 publications

References 212 publications

Multiple strategies of melatonin protecting against cardiovascular injury related to inflammation: A comprehensive overview

Multiple strategies of melatonin protecting against cardiovascular injury related to inflammation: A comprehensive overview

Melatonin as a putative protection against myocardial injury in COVID-19 infection

Supramolecular self‐assembled nanoparticles for targeted therapy of myocardial infarction by enhancing cardiomyocyte mitophagy

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