Cardiopulmonary bypass (CPB) for lung transplantation

Abstract

Surgeons have often been reluctant to use cardiopulmonary bypass (CPB) during single (SLTx) and double lung (DLTx) transplantation surgery because of the potential adverse sequelae of CPB including haemorrhage and activation of complement leading to sequestration of neutrophils and platelets in the pulmonary capillary bed, endothelial damage, increased capillary permeability and pulmonary oedema. To clarify the effect of CPB on lung transplant recipients, we reviewed our last four years' experience in 74 patients of whom 30 required CPB support. Indications for CPB were mean pulmonary artery pressure of greater than 50 mmHg, haemodynamic instability, hypoxia or hypercarbia. Patients undergoing SLTx were placed on CPB via the femoral artery and vein, while those undergoing DLTx were cannulated in the standard fashion using the ascending aorta and right atrium. All patients were administered aprotinin prior to CPB. Intraoperatively and postoperatively, haemorrhage was not a major problem. The 30-day mortality in the CPB group and the non-CPB group were 20% and 4.6%, respectively which was not statistically significant (p = 0.06). We conclude that CPB during lung transplantation is a safe, effective method to support these severely ill patients and should not be avoided because of concerns over adverse sequelae of CPB on postoperative graft function.

Current and future role of double-lung transplantation for bilateral lung cancer

“…A unique advantage of this technique is the possible avoidance of cardiopulmonary bypass (CPB). Although several studies have supported the use of CPB [ [63] , [64] , [65] ], there are concerns associated with it use which include bleeding, early graft dysfunction, acute-phase reaction of protease cascades, leukocyte and platelet activation resulting in tissue injury, and endothelial damage by increasing capillary permeability or pulmonary edema [ [66] , [67] , [68] , [69] ]. The technique of sequential lung transplant provides the flexibility regarding the use of CPB unlike the en bloc double lung transplant in which both lungs have to be simultaneously removed necessitating CPB [ 32 , 65 ].…”