Cardiopulmonary Side‐Effects and Pharmacokinetics of an Emulsion of Propofol (Disoprivan®) in Comparison to Propofol Solved in Polysorbate 80 in Goats

Bettschart‐Wolfensberger, Regula; Semder, A; Alibhai, Hatim; Demuth, Daniel; Aliabadi, F. Shojaee; Clarke, K.W.

doi:10.1046/j.1439-0442.2000.00289.x

Cited by 19 publications

(33 citation statements)

References 13 publications

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“…This demonstrates that alfaxalone causes excitementfree induction in goats, even without prior calming of the goats by sedatives. This is similar to what has been reported for propofol, a closely related induction agent (Bettschart-Wolfensberger et al 2000;Dzikiti et al 2009;Pablo et al 1997;Prassinos et al 2005).…”

Section: Discussionsupporting

confidence: 89%

The effects of midazolam and butorphanol, administered alone or combined, on the dose and quality of anaesthetic induction with alfaxalone in goats

Dzikiti¹,

Zeiler²,

Dzikiti³

et al. 2014

J S Afr Vet Assoc

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Goats are rarely anaesthetised; consequently, scant information is available on the efficacy of anaesthetic drugs in this species. Alfaxalone is a relatively new anaesthetic agent, of which the efficacy in goats has not yet been studied. In this study, the sedative and alfaxalone sparing effects of midazolam and butorphanol, administered alone or concomitantly, in goats were assessed. Eight clinically healthy goats, four does and four wethers, were enlisted in a randomised crossover manner to receive intramuscular sedative treatments consisting of saline 0.05 mL/kg, or midazolam 0.30 mg/kg, or butorphanol 0.10 mg/kg, or a combination of midazolam 0.30 mg/kg with butorphanol 0.10 mg/kg before intravenous induction of general anaesthesia with alfaxalone. Following induction, the goats were immediately intubated and the quality of anaesthesia and basic physiological cardiorespiratory and blood-gas parameters were assessed until the goats had recovered from anaesthesia. The degree of sedation, quality of induction and recovery were scored. When compared with saline (3.00 mg/kg), midazolam,administered alone or with butorphanol, caused a statistically significant increased level of sedation and a reduction in the amount of alfaxalone required for induction (2.00 mg/kg and 1.70 mg/kg, respectively). Butorphanol alone (2.30 mg/kg) did not cause significant changes in level of sedation or alfaxalone-induction dose. During induction and recovery, the goats were calm following all treatments, including the control group. Cardiorespiratory and blood-gas parameters were maintained within clinically acceptable limits. The present study showed that midazolam, administered alone or combined with butorphanol, produces a degree of sedation that significantly reduces the dose of alfaxalone required for induction of general anaesthesia in goats, without causing any major adverse cardiorespiratory effects.

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Section: Discussionsupporting

confidence: 89%

The effects of midazolam and butorphanol, administered alone or combined, on the dose and quality of anaesthetic induction with alfaxalone in goats

Dzikiti¹,

Zeiler²,

Dzikiti³

et al. 2014

J S Afr Vet Assoc

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“…Propofol is the most suitable of the induction drugs for administration as a constant rate infusion (CRI) due to its short context-sensitive half-time ( Bettschart-Wolfensberger et al 2000). Fentanyl, a short-acting μ opioid agonist, is used for treatment of moderate to severe pain in dogs and humans (Carroll et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats

Dzikiti

Stegmann

Dzikiti

et al. 2010

Veterinary Anaesthesia and Analgesia

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Objective To compare the efficacy and cardiopulmonary effects of propofol and fentanyl, with propofol and midazolam for total intravenous anaesthesia.Study Design Prospective, randomized, crossover experimental study.Animals Six healthy goats; 3 does and 3 wethers. ). MethodsCardiopulmonary function was well maintained with both treatments. Recovery times in minutes from the end of anaesthetic infusion for treatments FP and MP respectively were; to extubation 3.0 (3.0-3.0) and 4.5 (3.3-5.0); to sternal position, 4.5 (3.3-5.0) and 5.0 (5.0-6.5) and to standing 13.0 (10.3-15.0) and 15.0 (11.3-17.3). Quality of recovery was acceptable in both groups, but abnormal behavioural signs were observed after treatment FP. Conclusions and clinical relevanceTotal intravenous anaesthesia with propofol and fentanyl or propofol and midazolam, at the doses studied, in spontaneously-breathing, oxygen-supplemented goats is practicable. Recovery from the fentanyl-propofol combination is not always smooth.

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“…The maternal HR increased significantly after the 5 min of propofol induction in this study. Previously, the increase of maternal HR which could be ascribed to a decreased venous return caused by vascular dilation, has been seen transiently after propofol injection [5,10,30,32]. Following the injection, we saw a transient decrease of PO 2 which could be associated with FRC and RR reduction due to the suppressive effect on the maternal breath.…”

Section: Discussionmentioning

confidence: 48%

Effects of Propofol-Sevoflurane Anesthesia on the Maternal and Fetal Hemodynamics Blood Gases, and Uterine Activity in Pregnant Goats

Setoyama

Shinzato

Misumi

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. To determine the effects of propofol and sevoflurane on hemodynamics, acid-base balance and uterine activity in pregnant animals, a prospective experimental study was designed by use of ten pregnant goats. Propofol was intravenously administered at a bolus dose of 5 mg/kg and then infused a rate of 0.3 mg/kg/min for 5 min. Following the induction, the animals were incrementally inhaled 2.7 and 4.1% of end-tidal concentration of sevoflurane each for 30 min, and then recovered. The maternal and fetal heart rate (HR), arterial blood pressure (BP) and acid-base balance, the intrauterine pressure (IUP), and the uterine blood flow (UBF) were measured. Following the pre-anesthetic data, the parameters were measured 7 times throughout the anesthetic and recovering periods. The p ropofol infusion induced 1.37 times of HR increase and produced decrease in PO 2 and a relevant metabolic acidemia in the mother, with no effect in the fetus. Sevoflurane reduced BP in the fetus from 30 (2.7%) to 60 (4.1%) min of inhalation. The uterine contractions disappeared throughout sevoflurane inhalation, and then recurred within 15 min after the cessation of sevoflurane. Propofol injection increases HR, and induces a moderate hypoxemia and metabolic acidemia associated with the suppressed ventilation for pregnant goats, with less effect on the fetal hemodinamics. Sevoflurane causes minimal change in maternal hemodynamics, but induces significant hypotension in the fetus and reduction of uterine activity. These data may be useful in making anesthetic choices combined with analgesia for Caesarian section in goats.

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Cardiopulmonary Side‐Effects and Pharmacokinetics of an Emulsion of Propofol (Disoprivan®) in Comparison to Propofol Solved in Polysorbate 80 in Goats

Cited by 19 publications

References 13 publications

The effects of midazolam and butorphanol, administered alone or combined, on the dose and quality of anaesthetic induction with alfaxalone in goats

The effects of midazolam and butorphanol, administered alone or combined, on the dose and quality of anaesthetic induction with alfaxalone in goats

Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats

Effects of Propofol-Sevoflurane Anesthesia on the Maternal and Fetal Hemodynamics Blood Gases, and Uterine Activity in Pregnant Goats

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