Cardiorespiratory Arrest and Autonomic Neuropathy in Aids

Autonomic and cardiovascular function in HIV spectrum disease: Early indications of cardiac pathophysiology

“…Therefore, the present findings suggest that, although the early stages of HIV infection are marked by alterations in resting cardiac functioning, resting autonomic function remains intact. Although these data contradict those of some earlier case studies, uncontrolled clinical trials, and controlled studies using much smaller samples of patients in early stages of HIV spectrum disease [1][2][3]6,9], they are not without precedent [10]. During the final minute of the 5-minute handgrip exercise, a significantly diminished DBP response was observed in the HIV++ group, with a disproportionate number of symptomatic subjects showing low normal DBP responses relative to the normal controls (Fig.…”

“…There is growing evidence of altered cardiovascular and autonomic nervous system function among individuals infected with the human immunodeficiency virus (HIV) [1][2][3][4][5][6]. Observations of clinically manifested autonomic symptoms, such as orthostatic hypotension, syncope, impotence, urinary dysfunction, diminished sweating, and diarrhea have led researchers to posit that autonomic neuropathy and baroreceptor dysfunction may develop in HIV infected persons [7].…”

“…The measures typically employed to assess cardiac autonomic integrity include blood pressure and heart rate (HR) responses to a standardized battery of four simple cardiovascular reflex tests: Valsalva maneuver, lying-to-standing orthostatic maneuver, deep paced breathing, and sustained handgrip isometric exercise [8]. Many HIV infected individuals perform within normal ranges on these tests; however, studies using this testing battery indicate the incidence of cardiac autonomic dysfunction in asymptomatic HIV infected patients ranges from 0% to 53% [1][2][3]6,9] and is greater (from 13% to 100%) in later HIV stages [4--6,9-11]. It appears, therefore, that abnorThis study was supported by research grant PO 1-MH49548 and training grant T32-MH18917 from the National Mental Health Institute of the National Institutes of Health.…”

Estudo cardiológico longitudinal em crianças expostas ao vírus da imunodeficiência humana tipo 1 por via perinatal

“…According to the literature, changes The incidence of arrhythmia in this study was 7.3%, a low incidence compared to that reported in the literature, as only electrocardiogram was used. [58][59][60][61] Incomplete right bundle branch block was the most frequent manifestation in infected children (7 cases -17%). This conduction disturbance was the earliest of all changes, since it was the only one observed in the group of asymptomatic children.…”

HIV Associated Neuropathies

“…Autonomic symptoms however are often in other HIV-neuropathies, for instance HIV-SN. Studies investigating autonomic functions in HIVinfected patients describe different in part contrary results [75][76][77][78][79], which urges the need for larger RCT´s.…”