Cardiorespiratory patterns in siblings of babies with sudden infant death syndrome.

Abstract

The mothers of the siblings smoked and consumed alcohol more often during pregnancy than the mothers of control babies. The siblings had lower Apgar scores and were more often breast fed than controls.There were no significant differences in the number of apnoeic pauses in the quantities of periodic breathing or in the heart and respiratory rates during regular breathing between the siblings and the controls. In an attempt to resolve these conflicting findings we analysed heart rate and breathing patterns on 24 hour tape recordings of ECG and abdominal breathing movements on 78 siblings of cases of SIDS who had been born at full term (:37 weeks' gestation), and 170 age matched controls who had also been born at full term. We also include a comparison of prenatal and early postnatal clinical data between these 78 siblings and their 170 controls. PatientsControls. A total of 197 24-hour tape recordings of ECG and abdominal wall movements were performed on 170 control infants. These infants were born at one of four hospitals, were born at full term (¢37 weeks' gestation), and were chosen to cover the same age range as the siblings. A proportion was from a previously reported sequential control group;"l a second group was randomly selected from surviving infants being studied as part of a prospective investigation into SIDS;'2 and a small group of older infants was chosen randomly from a local health visitors' clinic in Doncaster.Prenatal and early postnatal clinical data were compiled from hospital notes and questionnaires given to parents at the time of the recordings. Four 721 on 7 May 2018 by guest. Protected by copyright.

Sudden Infant Death Syndrome: A Review of the Literature

“…Several studies have compared average heart rate, heart rate variability, and breathing patterns between infants who later died of SIDS and age-matched control infants. In most studies, only subtle or no differences in heart rate, cardiac variability, and respiratory variability were found [19][20][21][22]. Long QT, whether congenital or acquired, has been linked to SIDS for over 3 decades.…”

Evaluation of periodic breathing in infants

“…Auch wenn [22]. Ebenso wurden in einem Tell der Studien, die keine signifikanten Unterschiede zwischen sp~iteren SID-Opfern und Kontrollkindern nachweisen konnten, jewells einige Kinder beschrieben, die deutlich erh6hte Werte bei periodischer Atmung aufwiesen [14,50,51].…”

Schwankungen der Sauerstoffsättigung während periodischer Atmung

“…Einige Autoren fanden vermehrt periodische Atmung [16,17,19], andere Autoren konnten dies nicht bestä tigen [10,12,35]. Einige Autoren fanden vermehrt periodische Atmung [16,17,19], andere Autoren konnten dies nicht bestä tigen [10,12,35].…”