Cardiorespiratory Responses and Electrocardiographic Changes During Exercise Before and After Intravenous Digoxin in Normal Subjects

Pn, Yu; Fw, Lovejoy; Hulfish, B; Mm, Howell; Ha, Joos; Sm, Tenney; Lm, Haroutunian; Hw, Evans

doi:10.1097/00000441-195208000-00004

Cited by 10 publications

(1 citation statement)

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“…In normal subjects and in cardiac patients with Sinus rhythm and not in heart failure, digitalis often does not influence the heart rate, either at rest or during exercise (8,13).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Digitalis on the Heart Rate During Exercise in Patients With Atrial Fibrillation

Åberg¹,

Ström²,

Werner³

1972

Journal of Internal Medicine

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Twenty‐eight clinically compensated cardiac patients with atrial fibrillation have been investigated with the graded exercise test. Twenty‐four patients had one test with a lower dose of digitalis and one with a higher dose, both dose rates being within the therapeutic range. Four patients performed one exercise test with and one without digitalis. The heart (ventricular) rate attained at a given exercise load was significantly lower (with a difference of 5–25 beats/min at the different loads) with the higher dose. This was interpreted as a beneficial effect on working capacity. The individual beat‐to‐beat variability of heart rate was not influenced. The beneficial effect of an increase in digitalis dose thus seems to depend on a decrease in average ventricular rate during exercise and not on a decreased degree of arrhythmia.

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“…In normal subjects and in cardiac patients with Sinus rhythm and not in heart failure, digitalis often does not influence the heart rate, either at rest or during exercise (8,13).…”

Section: Discussionmentioning

confidence: 99%