Cardiotoxicity of de Gramont's Regimen: Incidence, Clinical Characteristics and Long-term Follow-up

Abstract

de Gramont's regimen has a lower incidence of cardiotoxicity compared with more prolonged 5-FU-based infusion regimens. Nevertheless, patients should still be carefully monitored especially in the first cycles and at night time.

5-fluorouracil induced cardiotoxicity: Review of the literature

“…The reported incidence of cardiotoxicity related to 5-FU ranges from 1.2% to 18% [1,2,[12][13][14]. This wide variation is believed to be related to dose dependency as well as the frequency of drug administration.…”

“…With shorter bolus regimens, the incidence of cardiotoxicity typically lies between 1.6% to 3% of cases [2]. With more prolonged regimens, these percentages increase to 7.6% to 18% [14]. Recently, a review of 377 cases of 5-FU associated cardiotoxicity confirmed that the majority of cases of cardiotoxicity occur in the setting of continuous infusion [6].…”

“…Angina has been shown to be one of the most common cardiac symptoms associated with 5-FU administration [14]. Up to 19% of the patients in a series of patients by Wacker et al [37] experienced angina during treatment, with episodes lasting up to 12 h after cessation of drug infusion.…”

A Case Of Coronary Vasospasm Due To 5-Fluorouracil Treatment: A Case Report

“…It was reported that the reversible angina continued up to 12 hours aft er the cessation of 5-FU in 19% of cases and recurred in 90% of patients following readministration 10 . For this reason, it is recommended to stop 5-FU and replace it with another chemotherapeutic agent in case of cardiotoxicity.…”

Cardiotoxicity associated with 5-flurouracil - A case series

“…The electrocardiogram (ECG) could showed signs of myocardial ischemia supraventricular tachycardia (SVT) and bradycardia. [7,8] …”