Cardiotoxicity Study of the Aqueous Extract of Corn Silk in Rats

Adedapo, Adeolu Alex; Babarinsa, Omotayo; Oyagbemi, Ademola Adetokunbo; Adedapo, Aduragbenro Deborah; Omobowale, Temidayo Olutayo

doi:10.1515/macvetrev-2015-0065

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…This herb contains proteins, vitamins, carbohydrates, calcium, potassium, manganese and sodium salts, volatile oils, and steroids. The diuretic action of CS is partly due to its significant K content [14][15][16]. CS is also known to be rich in phenolic compounds such as anthocyanin, p-coumaric acid, vanillic acid, protocatechuic acid, derivatives of hesperidin and quercetin, and bounded hydroxycinnamic acid components composed of p-coumaric and ferulic acid.…”

Section: Introductionmentioning

confidence: 99%

Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats

Tanideh¹,

Zarifi²,

Rafiee³

et al. 2018

GMJ

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Background: Cisplatin is a cytotoxic agent in cancer therapy. Nephrotoxicity is considered as a side effect of cisplatin usage. Using rate models, we studied the possible protective impact of corn-silk (CS) extract against cisplatin-induced nephrotoxicity.Materials and Methods: Thirty-five experimental rats were divided into five groups (n=7 per each group) as follow: C1: Control received distilled water only; C2: received one dose of cisplatin, and CS: received 300 mg/kg/day of CS. Both CS1 and CS2 received 200 and 300 mg/kg/day of the CS extract orally, individually, for eight consecutive days. CS1 and CS2 received a single dose of cisplatin on the first day only. The specific biochemical markers and histopathological alterations were evaluated.Result: According to our results, cisplatin administration could have induced severe degeneration in all parts of the nephron tubules and liver. Pre-treatment with CS exhibited a significant decrease in the malondialdehyde (MDA) levels as compared to the values obtained after treatment with cisplatin alone (P<0.01). Moreover, the CS extract with 200 mg dose showed significant (P<0.01) protection against the cisplatin-induced elevation of blood urea nitrogen. Further, the serum levels of alanine transaminase and aspartate transaminase were higher in the cisplatin-treated groups, when compared to the control group (P<0.05). Furthermore, the hepatic function was also improved in cisplatin-treated animals, which were pre-treated with CS.Conclusion: CS has the potential to attenuate nephrotoxicity and lipid peroxidation induced by cisplatin in rats.[GMJ.2018;7:e1258]

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Section: Introductionmentioning

confidence: 99%

Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats

Tanideh¹,

Zarifi²,

Rafiee³

et al. 2018

GMJ

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“…No signs of acute toxicity of aqueous extract up to 3200 mg/kg in mice after 48 h (Adedapo et al, 2016) and no signs of subchronic toxicity of aqueous corn silk extract 10 g/kg/d for 90 days) in rats (Wang et al, 2011). Inconsistent results found by Adedapo et al, 2016 10; respiratory (10); general and unspecified 7; Infusion of aromatic leaves used throughout MA for stomachache, cough, common cold, and flu.…”

Section: Consensus Analysismentioning

confidence: 97%

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

et al. 2020

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The quality of health care in Mesoamerica is influenced by its rich cultural diversity and characterized by social inequalities. Especially indigenous and rural communities confront diverse barriers to accessing formal health services, leading to often conflicting plurimedical systems. Fostering integrative medicine is a fundamental pillar for achieving universal health coverage (UHC) for marginalized populations. Recent developments toward health sovereignty in the region are concerned with assessing the role of traditional medicines, and particularly herbal medicines, to foster accessible and culturally pertinent healthcare provision models. In Mesoamerica, as in most regions of the world, a wealth of information on traditional and complementary medicine has been recorded. Yet these data are often scattered, making it difficult for policy makers to regulate and integrate traditionally used botanical products into primary health care. This critical review is based on a quantitative analysis of 28 survey papers focusing on the traditional use of botanical drugs in Mesoamerica used for the compilation of the "Mesoamerican Medicinal Plant Database" (MAMPDB), which includes a total of 12,537 use-records for 2188 plant taxa. Our approach presents a fundamental step toward UHC by presenting a pharmacological and toxicological review of the cross-culturally salient plant taxa and associated botanical drugs used in traditional medicine in Mesoamerica. Especially for native herbal drugs, data about safety and effectiveness are limited. Commonly used cross-culturally salient botanical drugs, which are considered safe but for which data on effectiveness is lacking constitute ideal candidates for treatment outcome studies.

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“…Four mice of each group were sacrificed on the 3 rd , 7 th and 14 th -day post burning of the skin, by deep anesthesia with chloroform (30). The site of the burns was grossly inspected to confirm the changes and it was measured by Vernier calipers.…”

Section: Animals' Sacrifice and Tissue Harvestingmentioning

confidence: 99%

“…Paraffin blocks were made and sectioned by microtome to 5 µm sections. Sections were stained with hematoxylin and eosin and inspected by a light microscope (30).…”

Section: Histopathologymentioning

confidence: 99%

Effect of Silver Nanoparticles on Healing of Third-Degree Burns Infected with Pseudomonas Aeruginosa in Laboratory Mice

Ramadhan

Balasm

Kadhm

et al. 2021

Macedonian Veterinary Review

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The treatment of full-thickness skin burn using nanomaterials is promising as a medical application reducing the risk of infection and severe dermal scarring. Therefore, this study aims to evaluate the effectiveness of nanomaterials, particularly 3% silver nanoparticles containing ointment (3% SNO), on the full-thickness skin burn of laboratory mice. A total number of 36 male mice were used, equally divided into three groups: negative control (not burned and not treated); positive control (+ve) (burned and treated with castor oil and white petroleum jelly); and SNO-treated group (burned and treated with 3% SNO). The skin of the animals’ back was shaved. A 2x0.5 cm metal plate was heated on a burner to burn the skin of the animals of positive control and SNO-treated groups. Pseudomonas aeruginosa bacterial suspension was applied to the burnt area. The application of SNO, as well as the mixture of white petroleum jelly and castor oil, was started after 6 hours of inducing burns and continued for 14 days (three times daily) in the respected groups. The SNO-treated group showed accelerated healing within 14 days demonstrated by re-epithelialization of the epidermal layer and proliferation of the fibroblasts in the dermal layer. Less healing evidence was observed in the +ve control group in the same period. In conclusion, to our knowledge, this is the first study that uses a 3% SNO formula and has found that it has a promising impact on the treatment of infected skin burns.

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Cardiotoxicity Study of the Aqueous Extract of Corn Silk in Rats

Cited by 5 publications

References 27 publications

Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats

Effect of Methanolic Extract of Corn Silk on Cisplatin-Induced Nephrotoxicity in Rats

Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage

Effect of Silver Nanoparticles on Healing of Third-Degree Burns Infected with Pseudomonas Aeruginosa in Laboratory Mice

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