Cardiovascular and respiratory responses to intravenous infusion of prostaglandin F2α in the pregnant woman

Fishburne, John I.; Brenner, William E.; Braaksma, J.T.; Staurovsky, Linda C.; Mueller, Robert A.; Hoffer, J. Lee; Hendricks, Charles H.

doi:10.1016/0002-9378(72)90898-8

Cited by 34 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pulmonary wedge pressure, heart rate and cardiac output seemed essentially unchanged. Unchanged cardiac output during PGF,, infusion in pregnant anesthetized women has previously been reported by Fishburn et al (12) and by us (24). However, in anesthetized dogs (21) an increase in cardiac output was found, which agrees with the present investigation in which an increase of 40% was recorded in anesthetized women during infusion of 300 pg/min F2cx.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Effect of Prostaglandin E₂ and F_2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Secher

Thayssen

Arnsbo

et al. 1982

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

The hemodynamic effect of prostaglandin F2 alpha (PGF2 alpha) and of prostaglandin E2 (PGE2) was studied in 12 healthy volunteers admitted for suction abortion at 10--12 weeks of gestation. They were anesthesized using natrium thiomebumal, pethidine and pancuronium bromide. PGF 2 alpha was given as an intravenous infusion of 100 micrograms/min, the dose being increased by 100 micrograms every 10 min to a maximum of 300 micrograms/min. PGE2 was administered with 5 micrograms/min, the dose being increased by 5 micrograms every 10 min to a maximum of 15 micrograms/min. During infusion of 300 micrograms PGF2 alpha a significant increase iun cardiac output and femoral arterial pressure of 40% and 25% respectively was measured together with an increase in the pulmonary arterial pressure (125%). Pulmonary vascular resistance was doubled, with a concomitant decrease in systemic resistance (11%). These changes were followed by a significant decrease in pH and PaO2, whereas an increase in PaCO2 was found. During infusion of PGE2 a significant, 36% increase in cardiac output was measured during infusion of 15 micrograms/min PGE2, together with a decrease in systemic blood pressure (31%) and resistance (33%). Heart rate rose significantly, while stroke volume showed only a small increase, and pulmonary pressure was unchanged. These changes were followed by an increase in PaO2. PGF2 alpha seems to have a positive inotropic effect on the heart, whereas its response to PGE2 seems to be a result of the peripheral vasodilatation. The slight decrease in systemic blood pressure without change in pulmonary hemodynamics makes PGE2 suitable for induction in patients with cardiopulmonary diseases.

show abstract

Section: Discussionsupporting

confidence: 92%

“…In pregnant women pre-treated with meperidine and prochlorperazine, Fishburn et al (12) did not find any significant changes in systemic arterial pressure during infusion of 200 pg PCF2,. The same has also been found by others (7, 23).…”

Section: Discussionmentioning

confidence: 91%

Effect of Prostaglandin E₂ and F_2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Secher

Thayssen

Arnsbo

et al. 1982

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…However, several studies have documented that intravenous or intra-amniotic administration of prostaglandin F2a to induce abortion can produce reversible bronchoconstriction with increased airway resistance (16)(17)(18)(19). It is unlikely that such airway responses produce clinically significant effects in healthy pregnant women, but more significant effects, including precipitation of asthmatic attacks, have been noted in women with underlying airway disease (16,17).…”

Section: Biochemicalmentioning

confidence: 99%

Pregnancy and The Lung^1,²

Se¹,

St²,

Cohen³

et al. 1980

Am Rev Respir Dis

308

110

View full text Add to dashboard Cite

“…In contrast, no leuko trienes were found in pulmonary lavage fluids in a group of infants requiring ventila tion who did not manifest the clinical signs of persistent pulmonary hypertension. Pros taglandin F2a is a cyclooxygenase metabolite of AA with constrictor effects of pulmonary blood vessels and airways [4][5][6], Infants with RDS may have significantly increased levels of this metabolite when compared to control infants [12].…”

Section: Discussionmentioning

confidence: 99%

“…Thromboxanes [1][2][3], prostaglandins [4][5][6] and leukotrienes [7][8][9] are arachidonic acid (AA) metabolites with potent vasoconstrictor and bronchoconstricctor activities. Recently these products have been implicated in the pathophysiology of pulmonary hypertension and respiratory distress in the neonate [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Decreased Plasma Arachidonic Acid Binding Capacity in Neonates

Pd¹,

Rw²,

Clark³

et al. 1987

Neonatology

View full text Add to dashboard Cite

Arachidonic acid (AA) metabolites have been implicated in neonatal pathologic states such as respiratory distress syndrome (RDS). Since free (nonprotein bound) AA is the substrate for synthesis of these compounds, a decreased capacity to bind AA in neonatal plasma could contribute to these disorders. AA binding was assayed by equilibrium dialysis in plasma samples from healthy adults and various infant groups. Plasma from these infant groups bound significantly less AA than adult plasma. Premature infants with RDS and premature infants receiving intralipid had the lowest capacity to bind AA. The increased availability of free AA may be important in neonatal pathophysiologic states involving arachidonate metabolites.

show abstract

Cardiovascular and respiratory responses to intravenous infusion of prostaglandin F2α in the pregnant woman

Cited by 34 publications

References 11 publications

Effect of Prostaglandin E₂ and F_2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Effect of Prostaglandin E₂ and F_2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Pregnancy and The Lung^1,²

Decreased Plasma Arachidonic Acid Binding Capacity in Neonates

Contact Info

Product

Resources

About

Cardiovascular and respiratory responses to intravenous infusion of prostaglandin F2α in the pregnant woman

Cited by 34 publications

References 11 publications

Effect of Prostaglandin E2 and F2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Effect of Prostaglandin E2 and F2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Pregnancy and The Lung1,2

Decreased Plasma Arachidonic Acid Binding Capacity in Neonates

Contact Info

Product

Resources

About

Effect of Prostaglandin E₂ and F_2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Effect of Prostaglandin E₂ and F_2α on the Systemic and Pulmonary Circulation in Pregnant Anesthetized Women

Pregnancy and The Lung^1,²