Cardiovascular autonomic dysfunctions and sleep disorders

Calandra-Buonaura, Giovanna; Provini, Federica; Guaraldi, Pietro; Plazzi, Giuseppe; Cortelli, Pietro

doi:10.1016/j.smrv.2015.05.005

Cited by 96 publications

(44 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…At any given time, 50% of the general population are affected with one or more sleep problems such as difficulty in falling or staying asleep, staying awake, or adhering to a consistent sleep/wake schedule [4]. Chronic deprivation of quality sleep can increase the activity of the sympathetic nervous system leading to the disruption of the circadian clock affecting the whole body including the brain [5] and the cardiovascular systems' health [6]. This is concerning due to the fact that adequate sleep quality and quantity is required for the maintenance of mental and physical well-being, especially in those living with a chronic disease.…”

Section: Introductionmentioning

confidence: 99%

Sleep Abnormalities in Multiple Sclerosis

Sakkas

Giannaki

Karatzaferi

et al. 2019

Curr Treat Options Neurol

View full text Add to dashboard Cite

Purpose of review: This review summarizes the most well documented sleep disorders seen in patients with Multiple Sclerosis (MS), with a special focus on the impact on quality of life. Recent findings: Sleep abnormalities in patients with MS are a multifactorial and relatively complex issue affecting approximately 60% of the patients while the pathophysiology of these symptoms is not fully understood. Circadian rhythm disorders and increased levels of Pro-inflammatory Cytokines have been recognized as potential players in affecting sleep homeostasis in MS patients. Medication related side effects such as in immunotherapy and other factors such as lesion load can contribute to the disruption of normal sleep patterns. Summary: Most frequently encountered sleep disorders are insomnia, sleep-related movement disorders, sleeprelated breathing disorders and circadian rhythm disorders affecting both adults and paediatric MS populations. Aetiology still remains unknown with treatment options focusing on behavioural cognitive therapy, life style modification including improvement in sleep hygiene as well as melatonin supplementation. Given MS prevalence is still rising affecting millions of people, more personalized medicine applications should possibly form the key approach for improving patients' quality of life and quality years.

show abstract

Section: Introductionmentioning

confidence: 99%

Sleep Abnormalities in Multiple Sclerosis

Sakkas

Giannaki

Karatzaferi

et al. 2019

Curr Treat Options Neurol

View full text Add to dashboard Cite

show abstract

“…An essential mechanism in the human body is the activation of the sympathoadrenal axis (SAA) and the hypothalamic-pituitary axis (HPA) to maintain physiological stability and empower the individual against stress signals (2,3). Research on the HPA and SAA activity in response to human physiological stress is on the rise and it is generally expected that there is a symmetry between the structure of the HPA and SAA (4).…”

Section: Introductionmentioning

confidence: 99%

Effect of Exercise with Mental Stress on Cortisol and Alpha-Amylase Changes in Young Men

Ameri

Ghazalian

Shakeri

et al. 2019

Middle East J Rehabil Health Stud

View full text Add to dashboard Cite

Background: Physiological stress due to physical activity associated with mental stress can affect the responses of the sympathoadrenal axis and the hypothalamic-pituitary axis. Objectives: The present study aimed to investigate the effect of exercise with mental stress on cortisol and alpha-amylase changes in young men. Methods: In a quasi-experimental study, 20 inactive healthy men were randomly selected and divided into two groups of exercise and exercise with mental stress. The exercise group pedaled on a fixed bike at an intensity of 60% of maximal aerobic power for 37 minutes and the exercise group with mental stress received 20 minutes of mental stress (from 12th minutes to 32nd minutes) during the 37 minutes of pedaling. Salivary samples were collected before and immediately after the end of the exercise. Results: The exercise had a significant effect on increasing salivary cortisol (P = 0.007) and alpha-amylase (P = 0.01). Exercise with mental stress had a significant effect on salivary cortisol (P = 0.004) and alpha-amylase (P = 0.04). The exercise and exercise with mental stress had the same effects on increasing salivary cortisol (P = 0.42) and alpha-amylase (P = 0.83). Conclusions: It seems that exercise and exercise with mental stress have the same effects on increasing salivary cortisol and alphaamylase levels.

show abstract

“…Complex reciprocal counterbalances between the HPA axis and SAM system have been described, and stress-induced chronic stimulation and dysregulation of these systems may cause metabolic abnormalities (8–13). …”

Section: Introductionmentioning

confidence: 99%

Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk

Cozma

et al. 2017

Braz J Med Biol Res

View full text Add to dashboard Cite

Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and α-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and α-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators. A comprehensive search of PubMed, Web of Science and Scopus electronic databases was performed, and 54 key articles related to the use of salivary cortisol and α-amylase as subclinical indicators of stress and CV/CMR factors, including studies that emphasized methodological biases that could influence the accuracy of study outcomes, were ultimately identified. Overall, the biological impact of stress measured by salivary cortisol and α-amylase was associated with CV/CMR factors. Results supported the use of salivary cortisol and α-amylase as potential diagnostic tools for detecting stress-induced cardiac diseases and especially to describe the mechanisms by which stress potentially contributes to the pathogenesis and outcomes of CV diseases.

show abstract

Cardiovascular autonomic dysfunctions and sleep disorders

Cited by 96 publications

References 136 publications

Sleep Abnormalities in Multiple Sclerosis

Sleep Abnormalities in Multiple Sclerosis

Effect of Exercise with Mental Stress on Cortisol and Alpha-Amylase Changes in Young Men

Salivary cortisol and α-amylase: subclinical indicators of stress as cardiometabolic risk

Contact Info

Product

Resources

About