Cardiovascular changes during pregnancy in ewes

Metcalfe, James; Parer, J. T.

doi:10.1152/ajplegacy.1966.210.4.821

Cited by 48 publications

(23 citation statements)

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“…The decrease in arterial blood pressure that we observed during preg nancy as compared to the puerperium is of the same magnitude (10-15%) as that reported in pregnant humans [2] and sheep [10]. In addition, vascular reactivity to A-2 was significantly diminished during pregnancy as com pared to that found at 1 week postpartum in nonnursing animals.…”

Section: Discussionsupporting

confidence: 84%

Blood Pressure and Pressor Response to Angiotensin II during Pregnancy and Nursing in the Rabbit

Katz

Creasy

1981

Gynecol Obstet Invest

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A continuous study to determine blood pressure and pressor response to angiotensin II (A-2) during pregnancy and postpartum was performed in a chronic rabbit preparation. The resting blood pressure during pregnancy was found to be lower than that in the postpartum period. Pressor response to A-2 was diminished during pregnancy and during nursing, but in the absence of nursing, this response returned to normal values by 1 week postpartum. Inhibition of prostaglandin synthetase caused a significant increase in the pressor response to A-2 during gestation, but did not change the resting blood pressure either before or after delivery. The results are discussed in light of previous animal and human studies, and factors which could affect vascular reactivity during gestation and nursing are analyzed.

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Section: Discussionsupporting

confidence: 84%

Blood Pressure and Pressor Response to Angiotensin II during Pregnancy and Nursing in the Rabbit

Katz

Creasy

1981

Gynecol Obstet Invest

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“…They showed that cardiac output and heart rate were elevated and mean arterial pressure and peripheral resistance decreased. These changes were similar to those seen In pregnant ewes (25). Other studies of women taking oral contraceptives have also demonstrated Increased cardiac output, stroke volume, blood volume and blood pressure (25,27).…”

supporting

confidence: 82%

“…These changes were similar to those seen In pregnant ewes (25). Other studies of women taking oral contraceptives have also demonstrated Increased cardiac output, stroke volume, blood volume and blood pressure (25,27). In one study, progesterone and estrogen were administered separately (28).…”

supporting

confidence: 69%

Hemodynamics during pregnancy : a model for cardiac enlargement

Mendelson¹

2000

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Cardiac output Increases by 30-50% during mammal Ian pregnancy. This Increase Is reflected by elevation In both heart rate and stroke volume. The primary mechanism of Increased stroke volume appears to be cardiac enlargement, rather than increased preload, afterload, or contractll lty. Animal studies have shown that enlargement of the heart occurs prior to an Increase In uterine blood flow during pregnancy and this type of enlargement can be mimicked by sex steroid adm In I strati on.

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“…Blood volume in other species during pregnancy Values for rabbit from the present study,* Bjellin & Cartert (1977) and Nuwayhidt (1979), for cow from Reynolds (1953 a, b), for sheep from Metcalfe & Parer (1966), and for human from Hytten & Leitch (1971).…”

Section: Site Of the Blood Volume Increasementioning

confidence: 61%

Blood Volume in the Pregnant Rabbit

Prince

1982

Exp Physiol

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SUMMARYRed cell and plasma volumes were measured using "Cr-labelled red cells and l2"I-labelled HSA respectively, in seventeen pregnant rabbits at 28-29 days ofpregnancy, and fifteen non-pregnant rabbits weight-matched with the pregnant rabbits before mating. Red cell volume in the pregnant group (200 + 27 ml. kg-'; mean+ S.D.), was greater than in the control rabbits (180 + 20 ml. kg-1; P < 0 05); plasma volumes (390 + 4-5 and 37-3 + 4-4 ml. kg-' respectively) were not statistically different. Blood volume was derived from the sum of independently measured red cell and plasma volumes. That of the pregnant group (59 0 + 5-3 ml. kg-') was just significantly greater than that of the control rabbits (55 3 + 5 3 ml. kg-'; P < 0-05). When the volume ofdistribution of the labels was corrected, by subtracting fetal weight from maternal body weight, the red cell, plasma and blood volumes were all significantly greater in the pregnant rabbits (P < 0-02). Although the large vessel haematocrit of the pregnant group (41-6 + 4-4%) exceeded that of the non-pregnant group (38 7+2-6%; P < 005), there was no significant difference in whole body haematocrit or Fcells (the ratio of whole body to large vessel haematocrit) between the two groups of rabbits.

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Cardiovascular changes during pregnancy in ewes

Cited by 48 publications

References 0 publications

Blood Pressure and Pressor Response to Angiotensin II during Pregnancy and Nursing in the Rabbit

Blood Pressure and Pressor Response to Angiotensin II during Pregnancy and Nursing in the Rabbit

Hemodynamics during pregnancy : a model for cardiac enlargement

Blood Volume in the Pregnant Rabbit

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