Cardiovascular comorbidity in the real clinical practice of an ambulatory physician. Comparative register research in the Ryazan region

Nizov, A A; Suchkova, Ekaterina I.; Дашкевич, О. В.; Трунина, Т П

doi:10.15829/1728-8800-2019-2-70-75

Cited by 5 publications

(7 citation statements)

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“…число людей в возрасте 60 лет и старше возрастет с 0,9 до 2 млрд (с 12% до 22% в общей численности населения мира), а, следовательно, ожидается и увеличение количества полиморбидных больных. Так, по данным исследования РЕКВАЗА [5] у 91% пациентов, вошедших в исследование, имелись сопутствующие заболевания, а их количество увеличивалось прямо пропорционально возрасту пациентов (p<0,001) [5].…”

Section: Introductionunclassified

“…Для пациентов с сердечно-сосудистыми заболеваниями (ССЗ) коморбидность является характерной особенностью, которая во многом определяет прогноз, клиническую картину, а также продолжительность и качество жизни пациентов [1,5,6].…”

Section: Introductionunclassified

“…Повышенное артериальное давление (АД), дислипидемия, увеличение толщины комплекса интимамедиа сонных артерий -все это может способствовать развитию острых нарушений мозгового кровообращения, инфаркта миокарда, сердечной недостаточности и нарушения функции почек [5,7]. В регистровом исследовании А.А.…”

Section: Introductionunclassified

“…Низов и соавт. [5] показали, что в структуре заболеваемости кардиоваскулярная коморбидность занимала одно из ведущих мест. В период с 2012 по 2016 гг.…”

Section: Introductionunclassified

“…частота различных сочетаний ССЗ возросла с 82% (n=820) до 89,7% (n=897), при этом наиболее часто отмечались сочетание артериальной гипертензии (АГ), ишемической болезни сердца (ИБС) и хронической сердечной недостаточности (ХСН) -37,6% (n=376) больных; сочетание АГ и ХСН отмечено у 42,7% (n=427) пациентов, а АГ, ХСН и постинфарктного кардиосклероза -у 9,4% (n=94). Только АГ, без других сопутствующих ССЗ, имели лишь 10,3% (n=103) пациентов, вошедших в исследование [5].…”

Section: Introductionunclassified

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Levocarnitine for the Treatment of Polymorbid Patients

Переверзев

Shevchenko

Filippova

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Effective and safe treatment of patients with polymorbidity is an urgent task of modern healthcare. Of particular difficulty is the treatment of patients with cardiovascular comorbidity, which requires an integrated approach to the treatment and development of a special, so-called patient-oriented approach. Modern scientific evidence proposes the use of levocarnitine, as part of complex therapy to increase its effectiveness. So, it was shown that levocarnitine can have a beneficial effect on blood pressure in patients with hypertension, especially those who are overweight and obese. Levocarnitine is also effective in the treatment of heart failure, which has been studied in several clinical studies, which demonstrated its ability to increase the ejection fraction of the left ventricle, stroke volume of blood and other indicators. Optimization of the bioavailability of nitrogen oxide (NO) and a decrease in systemic oxidative stress while taking levocarnitine plays an important positive role in complex therapy in patients with coronary artery disease: exertional angina and post-infarction cardiosclerosis, reducing the number of anginal attacks. Since levocarnitine has powerful antioxidant effects, it also has the neuroprotective effect found in in vitro studies in animal experiments. In case of impaired renal function, due to accelerated elimination and impaired reabsorption, a deficiency of levocarnitine in the body tissues develops, and therefore the US Food and Drug Administration (US FDA) decided on the possibility of using levocarnitine in patients on hemodialysis. Thus, taking into account the positive effects of levocarnitine in a number of frequently combined diseases, it can be considered as the drug of choice in the treatment of patients with polymorbidity.

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Section: Introductionunclassified

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Levocarnitine for the Treatment of Polymorbid Patients

Переверзев

Shevchenko

Filippova

et al. 2020

Racionalʹnaâ farmakoterapiâ v kardiologii

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Structure Of Comorbidity In Urban Population With Essential Hypertension In The Clinical Practice Of A Local General Practitioner

et al. 2022

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Taking into account gender- and age-related features, to examine the structure of comorbidity in outpatients with essential hypertension residing in the city of Tambov. Material and Methods — This research was an observational cross-sectional study based on data extracted from 47,113 electronic medical records (EMRs) of patients 20-99 years of age residing in Tambov. The study included 29,282 (62.2%) women and 17831 (37.8%) men. Results — Essential hypertension is habitually associated with osteochondrosis (41.5% of patients with hypertension), cerebrovascular diseases (35.1%), arthrosis (28.3%), ischemic heart disease (IHD) (28.7%), menopausal disorders (17.5%), pancreatic diseases (15.4%), diabetes mellitus (14.7%), benign mammary dysplasia (14.2%), retinal diseases (12.9%), disorders of lipoprotein metabolism (12.4%), senile cataract (10.6%), gastritis and duodenitis (10.7%), varicose veins (10.1%), and thyroid diseases (10.0%). IHD is more common among men with hypertension, while other comorbidities are more characteristic for women. The most striking gender-related difference was associated with the finding that women with hypertension had varicose veins as a comorbidity (RR=1.398; 95% CI 1.376-1.422), while the smallest difference between genders related to retinal diseases (RR=1.065; 95% CI 1.038-1.092). IHD was strongly associated with the male gender (RR=1.101; 95% CI 1.056-1.148). Three diseases were more often associated with hypertension in the age range of 80-89 years (cerebrovascular disease, IHD, osteochondrosis); some of the diseases had the highest incidence in the age range of 60-69 years, and other disorders occurred in the age range of 40-59 years. Conclusion — The gender- and age-related features of comorbid pathology associated with essential hypertension among urban residents revealed in this study are extremely important in the clinical practice of a local general practitioner for developing optimal patient-oriented treatment plans.

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Association of Arterial Hypertension with Hepatobiliary Pathology: The Occurrence of Comorbidity and Features of Metabolic Processes

Viktorovna

Alekseevich

Polyakov

et al. 2020

CHYR

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: Comorbidity of hypertension and hepatobiliary pathology has negative medical and social consequences, including increase in indicators of hospital admissions, disability and mortality. Objective: To study the occurrence of hypertension combined with hepatobiliary diseases depending on social status, gender and age in 2003-2017 and the features of its influence on indicators of metabolic processes in patients of therapeutic profile. Method: A cross-sectional study using the inpatients medical record database of the clinic of Federal Research Centre for Basic and Translational Medicine (Novosibirsk, Russia), which collects demographics, diagnoses (using ICD-10 codes), procedures and examinations of all inpatients from 2003-2017 was conducted. A study of the incidence of comorbidity of hypertension and hepatobiliary pathology depending on age, gender and social status, based on the analysis of 13496 medical records was made. A comparative analysis of biochemical parameters characterizing the main types of 1 metabolism (lipid, protein, carbohydrate and purine) was carried out in 3 groups of patients: with hypertension; with hepatobiliary pathology, with a combined pathology. Results: In 2003-2005 years there was the greatest frequency of this comorbidity in workers, in women, in the age group 60 years and older. In 2009-2017 years the highest incidence was in male administrative staff. In patients with this comorbidity more pronounced changes in carbohydrate, protein, lipid and purine metabolism were found in comparison with groups of patients with isolated diseases, Conclusion: The results make it necessary to improve the system of prevention and treatment of comorbidity taking in account sex, age, occupation and features of metabolism.

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Cardiovascular comorbidity in the real clinical practice of an ambulatory physician. Comparative register research in the Ryazan region

Cited by 5 publications

References 5 publications

Levocarnitine for the Treatment of Polymorbid Patients

Levocarnitine for the Treatment of Polymorbid Patients

Structure Of Comorbidity In Urban Population With Essential Hypertension In The Clinical Practice Of A Local General Practitioner

Association of Arterial Hypertension with Hepatobiliary Pathology: The Occurrence of Comorbidity and Features of Metabolic Processes

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