Cardiovascular disease in patients with severe mental illness

Nielsen, René Ernst; Banner, Jytte; Jensen, Svend Eggert

doi:10.1038/s41569-020-00463-7

Cited by 238 publications

(194 citation statements)

References 174 publications

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“…Further research is needed using longer follow-up to decipher the puzzle. In men and women diagnosed with bipolar disorder (BPD), CVD contributes 17.4 and 22.0%, respectively, reduction in overall life expectancy (Nielsen et al, 2020 ). However, the vascular-bipolar link is difficult to study due to the latency between the onset of BPD, which is usually from an early age, and subsequent vascular disease.…”

Section: Resultsmentioning

confidence: 99%

Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis

et al. 2021

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This study aimed to conduct a bibliometric analysis of published studies on the association between coronary heart disease (CHD) and depression or anxiety. The study also aimed to identify leading authors, institutions, and countries to determine research hotspots and obtain some hints from the speculated future frontiers. Publications about CHD and depression or anxiety between 2004 and 2020 were collected from the Web of Science Core Collection (WOSCC) database. Bibliographic information, such as authorship, country, citation frequency, and interactive visualization, was generated using VOSviewer1.6.16 and CiteSpace5.6.R5. In total, 8,073 articles were identified in the WOSCC database. The United States (2,953 publications), Duke University and Harvard University (214 publications), Psychosomatic Medicine (297 publications), and Denollet Johan. (99 publications) were the most productive country, institutions, journal, and author, respectively. The three hotspots of the research were “The relationship between depression and CHD,” “depression and myocardial infarction,” and “The characteristic of women suffering depression after MI.” The four future research frontiers are predicted to be “treating depression in CHD patients with multimorbidity,” “psychometric properties of instruments for assessing depression and anxiety in CHD patients,” “depression or anxiety in post-PCI patients,” and “other mental diseases in CHD patients.” Bibliometric analysis of the association between CHD and depressive disorders might identify new directions for future research.

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Section: Resultsmentioning

confidence: 99%

Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis

et al. 2021

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“…It is characterized by recurring episodes of mood changes, featuring recurring episodes of depression and (hypo−)mania. In comparison to the general population, individuals with BD have a decreased life expectancy ( Kessing et al, 2015 ) due to heightened suicide risk, acute psychopathology, sociopsychological consequences (e.g., low socioeconomic status), and psychiatric comorbidities (e.g., substance use disorder), but also due to somatic comorbidities and obesity ( Zhao et al, 2016 ; Yamagata et al, 2017 ) and related cardiovascular and metabolic illness, such as diabetes mellitus ( Crump et al, 2013 ; Vancampfort et al, 2016 ) and cardiovascular disease ( Westman et al, 2013 ; Nielsen et al, 2021 ). Evidently, diseases of metabolic nature constitute particular risk factors for premature mortality in BD ( de Almeida et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome Impairs Executive Function in Bipolar Disorder

et al. 2021

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Background: Metabolic syndrome (MetS) is more prevalent in individuals with bipolar disorder and has a negative impact on cognition, in particular on executive function, which is already impaired in individuals with bipolar disorder compared to healthy controls.Methods: In a cross-sectional study, we compared 148 euthymic patients with bipolar disorder and 117 healthy controls in cognitive function depending on the diagnosis of MetS. A neuropsychological test battery was used including the Trail Making Test A/B, Stroop Color and Word Interference Test, the d2 Test of Attention Revised, and the California Verbal Learning Test. In addition, MetS variables as well as the defining variables waist circumference, serum triglyceride levels, high-density lipoprotein cholesterol levels, blood pressure, fasting glucose levels, and body mass index were compared between patients and controls. In addition, illness-related variables were associated with MetS in individuals with bipolar disorder.Results: The prevalence of MetS in patients with bipolar disorder was higher than in controls (30.4 vs. 15.4%). Patients with bipolar disorder with MetS had impaired executive function compared to patients without MetS or healthy controls with and without MetS (p = 0.020). No MetS effects or interaction MetS × Group was found in attention/processing speed (p = 0.883) and verbal learning/memory (p = 0.373). Clinical variables (illness duration, suicidality, number of affective episodes, medication, age of onset, and history of psychosis) did not relate to MetS in bipolar disorder (p > 0.05).Conclusion: Bipolar disorder comorbid with MetS bears additional risk for impaired executive function. Executive function includes action planning, inhibition, and impulse control and could play a critical role in keeping long-term goals in mind associated with gaining and maintaining a healthy weight.

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“…Fourth, psychiatric comorbidities were not an exclusion criterion. They are associated with the prevalence of cardiovascular disease, a higher rate of cardiovascular risk factors and other risk factors shared with cocaine use, such as unhealthy lifestyle and social deprivation ( 47 ), possibly leading to a confounding bias. Fifth, our study population was composed of cocaine users currently in care.…”

Section: Discussionmentioning

confidence: 99%

Risk and Protective Factors of Lifetime Cocaine-Associated Chest Pain

et al. 2021

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Introduction: Cocaine users often present with repetitive events of cocaine-associated chest pain (CACP), clinically resembling acute coronary syndromes. The aim of the study is to describe the specific risk factors for CACP.Method: Cocaine users (n = 316) were recruited for a multicenter cross-sectional study. Lifetime CACP history, sociodemographic factors, and lifetime use of cocaine and other substances were assessed. Thirty single nucleotide polymorphisms (SNPs) of NOS3, ROCK2, EDN1, GUCY1A3, and ALDH2 genes, suggested by the literature on coronary spasms, were selected. The associations with CACP history were tested using the chi-square test, Student's t-test and logistic regression.Results: Among the 316 subjects [78.5% men, mean age 37.5 years, (standard-deviation ±8.7)], 190 (60.1%) were daily cocaine users and 103 (32.6%) reported a lifetime CACP history. Among those with a lifetime CACP history, the median was 10 events per individual. In multivariate analysis, lifetime CACP history was associated with daily cocaine use [odds-ratio (OR) 3.24; 95% confidence intervals (1.29–9.33)], rapid route of cocaine use [OR 2.33 (1.20–4.64) vs. intranasal use], and lifetime amphetamine use [daily amphetamine use: OR 2.80 (1.25–6.32) and non-daily amphetamine use: OR 2.14 (1.15–4.04) vs. never used]. Patients with lifetime opioid maintenance treatment (OMT) reported significantly less lifetime CACP history [OR 0.35 (0.16–0.76)]. None of the selected SNPs was associated with CACP history after multiple testing corrections.Conclusions: Clinical variables describing the intensity of stimulant use were positively associated with lifetime CACP history, while OMT was negatively associated with it. Specific harm reduction strategies can target these risk factors.

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Cardiovascular disease in patients with severe mental illness

Cited by 238 publications

References 174 publications

Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis

Coronary Heart Disease and Depression or Anxiety: A Bibliometric Analysis

Metabolic Syndrome Impairs Executive Function in Bipolar Disorder

Risk and Protective Factors of Lifetime Cocaine-Associated Chest Pain

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