Cardiovascular disease risk factors in chronic renal insufficiency

Sarnak, Mark J.; Coronado, Boris E.; Greene, Tom; Wang, S. R.; Kusek, John W.; Beck, Gerald J.; Levey, Andrew S.

doi:10.5414/cnp57327

Cited by 196 publications

(120 citation statements)

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“…In end-stage renal disease patients, LDLcholesterol is usually reduced or within the normal range. 16 About 86% of our patients were hypertensive and/or on antihypertensive therapy, similiar to the studies of Coresh et al 17 and Buckalew et al 18 About 77% of the patients were 14 who found no significant association between diastolic blood pressure and GFR. In our study population, patients who were on renal replacement therapy were more lean than the patients in the other groups, so this might influence our results on hypertension.…”

Section: Discussionsupporting

confidence: 63%

Frequency of Cardiovascular Risk Factors and Metabolic Syndrome in Patients with Chronic Kidney Disease

Sagun¹,

Kantarcı²,

Mesçi³

et al. 2010

Clinical Medicine & Research

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Section: Discussionsupporting

confidence: 63%

Frequency of Cardiovascular Risk Factors and Metabolic Syndrome in Patients with Chronic Kidney Disease

Sagun¹,

Kantarcı²,

Mesçi³

et al. 2010

Clinical Medicine & Research

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“…49 Several cross-sectional studies have suggested that the Framingham risk equation is insufficient to capture the extent of CVD risk in subjects with CKD. 17,50,51 There are 2 interpretations for these findings. First, other factors (nontraditional risk factors) that are not included in Framingham risk equations may play an important role in promoting ischemic…”

Section: Cvd Risk Factors In Ckdmentioning

confidence: 99%

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

Sarnak¹,

Levey²,

Schoolwerth³

et al. 2003

Circulation

3,061

752

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“…For example, two large randomized trials failed to demonstrate a benefit of statin therapy to reduce cardiovascular disease risk in hemodialysis patients (8,9). As traditional cardiovascular risk factors are insufficient to predict and treat true cardiovascular disease risk in patients with CKD (10,11), it is assumed that CKD-specific pathways contribute substantially to the high cardiovascular disease risk.…”

mentioning

confidence: 99%

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

Meijers¹,

Claes²,

Bammens³

et al. 2010

Clinical Journal of the American Society of Nephrology

273

188

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Background and objectives: Cardiovascular disease is highly prevalent in chronic kidney disease. Traditional risk factors are insufficient to explain the high cardiovascular disease prevalence. Free p-cresol serum concentrations, mainly circulating as its derivative p-cresyl sulfate, are associated with cardiovascular disease in hemodialysis patients. It is not known if p-cresol is associated with cardiovascular disease in patients with chronic kidney disease not yet on dialysis.Design, setting, participants, & measurements: In a prospective observational study in 499 patients with mild-to-moderate kidney disease, we examined the multivariate association between p-cresol free serum concentrations and cardiovascular events.Results: After a mean follow-up of 33 mo, 62 patients reached the primary end point of fatal or nonfatal cardiovascular events. Higher baseline concentrations of free p-cresol were directly associated with cardiovascular events (univariate hazard ratio [HR] 1.79, P < 0.0001). In multivariate analysis, p-cresol remained a predictor of cardiovascular events, independent of GFR and independent of Framingham risk factors (full model, HR 1.39, P ‫؍‬ 0.04).Conclusions: These findings suggest that p-cresol measurements may help to predict cardiovascular disease risk in renal patients over a wide range of residual renal function, beyond traditional markers of glomerular filtration. Whether p-cresol is a modifiable cardiovascular risk factor in CKD patients remains to be proven.

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Cardiovascular disease risk factors in chronic renal insufficiency

Cited by 196 publications

References 0 publications

Frequency of Cardiovascular Risk Factors and Metabolic Syndrome in Patients with Chronic Kidney Disease

Frequency of Cardiovascular Risk Factors and Metabolic Syndrome in Patients with Chronic Kidney Disease

Kidney Disease as a Risk Factor for Development of Cardiovascular Disease

p-Cresol and Cardiovascular Risk in Mild-to-Moderate Kidney Disease

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